Increased expression of cytokines, soluble cytokine receptors, soluble apoptosis ligand and apoptosis in dengue

Arias, Julia; Valero, Nereida; Mosquera, Jesús; Montiel, Milagros; Reyes, Eduardo; Larreal, Yraima; Álvarez‐Mon, Melchor

doi:10.1016/j.virol.2013.12.027

Cited by 62 publications

(64 citation statements)

References 43 publications

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“…The same studies reported increased IL-6 levels in SD and DwWS relative to patients with DwoWS. Elevations in TNFRI and TNRFII in DwoWS, DwWS and SD (Arias et al, 2014) were similar to those observed in DHF patients (Wang et al, 2007).…”

Section: Prognostication Marker Candidates: Who (2009) Sdsupporting

confidence: 80%

“…Among them, one reported elevation in IL-10 (Malavige et al, 2013a), congruent with the seven WHO (1997) guideline-utilizing studies that reported elevations in IL-10 in DHF patients (Table 3), and one study reported elevated IL-10 levels in DwoWS, DwWS and SD patients compared to controls (Guerrero et al, 2013). Two studies reported elevations in sST2 (IL-1RL1) (Arias et al, 2014;Guerrero et al, 2013) in SD patients in levels above those of DwoWS and DwWS (Arias et al, 2014;Guerrero et al, 2013). The same studies reported increased IL-6 levels in SD and DwWS relative to patients with DwoWS.…”

Section: Prognostication Marker Candidates: Who (2009) Sdsupporting

confidence: 56%

“…A total of 19 out of 24 studies were case-control studies (Arias et al, 2014;Bozza et al, 2008;Brasier et al, 2012;Butthep et al, 2012;Chen et al, 2005;Furuta et al, 2012;Green et al, 1999a, b;Guerrero et al, 2013;Houghton-Triviño et al, 2010;De La Cruz Hern andez et al, 2014;Laur et al, 1998;Levy et al, 2010;Malavige et al, 2013a;Nguyen et al, 2004;Del Moral-Hern andez et al, 2014;P erez et al, 2004;Soundravally et al, 2014;Wang et al, 2007), and the remaining 5 studies were prospective cohort studies (de-Oliveira-Pinto et al, 2012;Kurane et al, 1991Kurane et al, , 1993Suharti et al, 2003). Comparison groups were healthy controls, patients with other febrile illness (OFI) or non-severe disease patients (DF or non-SD); however, comparisons made between SD and non-SD cases were considered most ideal for the purpose of this review.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The remaining studies had wider blood sampling windows, ranging from 1 to 10 days from symptom onset (Arias et al, 2014;Bozza et al, 2008;Chen et al, 2005;de-Oliveira-Pinto et al, 2012;Guerrero et al, 2013;Houghton-Triviño et al, 2010;Kurane et al, 1991Kurane et al, , 1993Laur et al, 1998;Levy et al, 2010;Del Moral-Hern andez et al, 2014;Nguyen et al, 2004;Suharti et al, 2003). A majority of studies (21/24, 87.5 %) employed ELISAs for quantification of single cytokine/chemokine, or multiplexed suspension bead immunoassays for broader profiling.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of the selected 24 studies, 4 studies (16.7 %) employed the WHO (2009) case definition (Arias et al, 2014;de-OliveiraPinto et al, 2012;Guerrero et al, 2013;Malavige et al, 2013a). Among them, one reported elevation in IL-10 (Malavige et al, 2013a), congruent with the seven WHO (1997) guideline-utilizing studies that reported elevations in IL-10 in DHF patients (Table 3), and one study reported elevated IL-10 levels in DwoWS, DwWS and SD patients compared to controls (Guerrero et al, 2013).…”

Section: Prognostication Marker Candidates: Who (2009) Sdmentioning

confidence: 99%

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Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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The prognosis of dengue remains a challenge in the early, objective triage of patients with dengue fever of differing severity. Circulating immuno-modulating proteins have brought new possibilities as prognostic markers of severe dengue (SD). This systematic review is devoted to understanding the potential utility of blood-based cytokines and chemokines as prognostication markers of SD based on the current literature. PubMed and Embase were searched. Of 794 candidate articles, 685 abstracts were screened against our exclusion/inclusion criteria and 25 (3.6 %) studies met the quality assessments. A total of 18 studies were retrospective observational and 2 were prospective cohort studies. Elevated IL-10, up to day 7 of fever onset, stood out as a candidate prognostic marker for SD using the 1997 and 2009 World Health Organization (WHO) case definitions. IFNg was another potential prognostic marker of SD (1997 WHO case definition), but its levels varied between studies. Significant heterogeneity in methodologies and patient cohorts prevent ready application of IL-10 and IFNg as prognostic markers to other dengue populations. Our results suggest that the current non-randomized studies are delivering inconsistent messages and higher-quality studies, with consistent methodologies and validation in independent patient cohorts, are needed to delineate confounding variables. Major gaps identified were full accounting and transparency of sampling days, dengue virus type, infection status and age group.

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Section: Prognostication Marker Candidates: Who (2009) Sdsupporting

confidence: 80%

Section: Prognostication Marker Candidates: Who (2009) Sdsupporting

confidence: 56%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Prognostication Marker Candidates: Who (2009) Sdmentioning

confidence: 99%

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Markers of dengue severity: a systematic review of cytokines and chemokines

Lee

Leong

Wilder‐Smith

2016

Journal of General Virology

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Endothelial dysfunction in dengue virus pathology

2014

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Dengue virus (DENV) is a leading cause of illness and death, mainly in the (sub)tropics, where it causes dengue fever and/or the more serious diseases dengue hemorrhagic fever and dengue shock syndrome that are associated with changes in vascular permeability. Despite extensive research, the pathogenesis of DENV is still poorly understood and, although endothelial cells represent the primary fluid barrier of the blood vessels, the extent to which these cells contribute to DENV pathology is still under debate. The primary target cells for DENV are dendritic cells and monocytes/macrophages that release various chemokines and cytokines upon infection, which can activate the endothelium and are thought to play a major role in DENV-induced vascular permeability. However, recent studies indicate that DENV also replicates in endothelial cells and that DENV-infected endothelial cells may directly contribute to viremia, immune activation, vascular permeability and immune targeting of the endothelium. Also, the viral non-structural protein-1 and antibodies directed against this secreted protein have been reported to be involved in endothelial cell dysfunction. This review provides an extensive overview of the effects of DENV infection on endothelial cell physiology and barrier function.

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Role of Monocytes in the Pathogenesis of Dengue

Castillo

Naranjo

Rojas

et al. 2018

Arch. Immunol. Ther. Exp.

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Diseases caused by dengue virus (DENV) are a major public health problem worldwide, considered one of the infections with more prevalence in tropical and subtropical zones of the world. Despite the intense research in the pathogenesis of DENV, this feature is not well understood. One of the main target cells for DENV infection is monocytes; these phagocytes can play a dual role, since they are essential to control viremia, but they also participate in the induction of tissue damage during DENV infection. Monocytes produce different pro-inflammatory cytokines and chemokines in response to infection, and also mediate endothelial damage. In peripheral blood, monocytes can be divided into three different subpopulations, namely classical, intermediate and non-classical, which differ in frequency, cytokine production, among others. Studies in the last years suggest that non-classical monocytes have higher affinity for microvasculature endothelium compared to other type of monocytes, which implies that they could be more involved in the increase of endothelial permeability observed during DENV infection. This review provides a general view of the role of monocytes and their subpopulations in DENV pathogenesis and its effect in viral replication. Finally, the potential contribution of these phagocytes in the alterations of endothelial permeability is discussed.

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Increased expression of cytokines, soluble cytokine receptors, soluble apoptosis ligand and apoptosis in dengue

Cited by 62 publications

References 43 publications

Markers of dengue severity: a systematic review of cytokines and chemokines

Markers of dengue severity: a systematic review of cytokines and chemokines

Endothelial dysfunction in dengue virus pathology

Role of Monocytes in the Pathogenesis of Dengue

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