Increased epicardial fat tissue is a marker of subclinical atherosclerosis in patients with psoriasis

Şen, Bilge Bülbül; Atci, Nesrin; Rifaioğlu, Emine Nur; Ekiz, Özlem; Kartal, İsmail; Büyükkaya, Eyüp; Kurt, Mustafa; Karakaş, Mehmet; Büyükkaya, Şule; Akçay, Adnan Burak; Şen, Nihat

doi:10.1111/bjd.12569

Cited by 33 publications

(34 citation statements)

References 38 publications

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“…In this study, the ratio of the presence of CAC was also significantly high in younger psoriatic patients. Clinical aspects, such as PASI score, hypertension and smoking habit, were not associated with EAT or CAC score, in agreement with previous reports …”

Section: Discussionsupporting

confidence: 92%

“…Epicardial adipose tissue functions as a paracrine organ by releasing bioactive adipocytokines into the adjacent interstitium of the myocardium and coronary arteries, and may represent cardiovascular risk . Recent studies have shown significantly higher EAT volume in psoriatic patients compared with control subjects, and EAT was independently associated with the presence of CAC . There is a correlation between EAT and BMI or metabolic syndrome, but Japanese psoriatic patients comprise only 0.34% of the population, with metabolic syndrome and obesity generally much less prevalent than Caucasians .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of epicardial adipose tissue volume and coronary artery calcification in Japanese patients with psoriasis vulgaris

Momose

Asahina

Fukuda

et al. 2018

The Journal of Dermatology

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Epicardial adipose tissue (EAT) is implicated in the development of coronary atherosclerosis by secretion of inflammatory adipocytokines. Recent studies have shown significantly higher EAT volume in psoriatic patients compared with that in control subjects, but this has not been validated in Japanese patients. We enrolled 86 Japanese patients with moderate to severe psoriasis vulgaris and 31 control subjects, and evaluated EAT volume and coronary artery calcification (CAC) by retrospectively assessing non-enhanced computed tomography obtained through routine examinations. Both mean EAT volume and mean CAC score were not significantly different between the two groups. Interestingly, however, a subanalysis with those of 50 years of age or less (28 psoriatic patients and seven non-psoriatic subjects) showed significantly higher mean EAT volume in psoriatic patients. Similarly, the ratio of the presence of at least one CAC was significantly higher in this group. Our findings suggest that Japanese psoriatic patients should also be aware of the cardiovascular risk, and EAT volume and CAC may be useful tools to predict such risk.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Evaluation of epicardial adipose tissue volume and coronary artery calcification in Japanese patients with psoriasis vulgaris

Momose

Asahina

Fukuda

et al. 2018

The Journal of Dermatology

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“…Prior studies have demonstrated associations between EFT and CVD, insulin resistance, coronary calcium score, and metabolic syndrome [13,36]. Previous studies have also reported that psoriatic patients had higher EFT values [16,37]. The present study found higher EFT values in psoriatic patients than in healthy controls, which agrees with the results of previous studies.…”

Section: Discussionsupporting

confidence: 91%

Chemerin as a marker of subclinical cardiac involvement in psoriatic patients

et al. 2017

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“…In a previous study, the authors demonstrated that EFT is increased in patients with psoriasis, and that echocardiographic EFT is closely correlated with surrogate inflammatory markers such as carotid intima media thickness in patients with psoriasis [10]. The echocardiographic assessment of EFT may have the potential to be a simple marker of subclinical atherosclerosis and increased cardiovascular risk in patients with psoriasis [10]. …”

mentioning

confidence: 99%