Increased Distractibility by Task‐Irrelevant Sound Changes in Abstinent Alcoholics

Ahveninen, Jyrki; Jä̈askëlainen, Iiro P.; Pekkonen, Eero; Hallberg, Anja; Hietanen, Marja; Näätänen, Risto; Schröger, Erich; Sillanaukee, Pekka

doi:10.1111/j.1530-0277.2000.tb01989.x

Cited by 47 publications

(23 citation statements)

References 35 publications

(34 reference statements)

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“…Acutely, alcohol has been shown to decrease MMN amplitude (He et al, 2013;Jaaskelainen et al, 1995a;Jaaskelainen et al, 1995b;Jaaskelainen et al, 1996;Kenemans et al, 2010), supporting the notion that alcohol elicits a blockade of the NMDA receptor (Lovinger et al, 1989). Additionally, increased MMN amplitudes have been found in alcohol dependent patients (Ahveninen et al, 2000b) supporting the upregulation of NMDA receptor functioning as a result of continued alcohol use (Krystal et al, 2003b).…”

Section: Mismatch Negativity Bipolar Disorder and Alcoholsupporting

confidence: 48%

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

Chitty

Lagopoulos

Hickie

et al. 2015

Neuroscience & Biobehavioral Reviews

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In a series of neurophysiological and neuroimaging studies we investigated the neurobiology related to alcohol use in young people with bipolar disorder. Impairments were identified across frontal and temporal representations of event-related potential and proton magnetic resonance spectroscopy markers; mismatch negativity and in vivo glutathione, respectively. We propose these findings reflect impairments in the Nmethyl-D-aspartate receptor and antioxidant capacity. This review seeks to place these findings within the broader literature in the context of two propositions:

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Section: Mismatch Negativity Bipolar Disorder and Alcoholsupporting

confidence: 48%

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

Chitty

Lagopoulos

Hickie

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…Standard trials immediately following novel trials were excluded from the analysis, as these have been shown to yield residual distraction [72].…”

Section: Resultsmentioning

confidence: 99%

Plasticity of Attentional Functions in Older Adults after Non-Action Video Game Training: A Randomized Controlled Trial

et al. 2014

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A major goal of recent research in aging has been to examine cognitive plasticity in older adults and its capacity to counteract cognitive decline. The aim of the present study was to investigate whether older adults could benefit from brain training with video games in a cross-modal oddball task designed to assess distraction and alertness. Twenty-seven healthy older adults participated in the study (15 in the experimental group, 12 in the control group. The experimental group received 20 1-hr video game training sessions using a commercially available brain-training package (Lumosity) involving problem solving, mental calculation, working memory and attention tasks. The control group did not practice this package and, instead, attended meetings with the other members of the study several times along the course of the study. Both groups were evaluated before and after the intervention using a cross-modal oddball task measuring alertness and distraction. The results showed a significant reduction of distraction and an increase of alertness in the experimental group and no variation in the control group. These results suggest neurocognitive plasticity in the old human brain as training enhanced cognitive performance on attentional functions.Trial RegistrationClinicalTrials.gov NCT02007616

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“…Turning attention back to the primary task after it has been oriented away is indexed by a later negative deflection (occurring around 500 msec from stimulus onset) termed RON (Ahveninen et al, 2000;Berti & Schröger, 2001;Escera, Yago, & Alho, 2001;Schröger, Giard, & Wolff, 2000;Schröger & Wolff, 1998a). RON is elicited only by task-irrelevant sound changes, following P3a in time.…”

Section: Ronmentioning

confidence: 99%

Top-down control over involuntary attention switching in the auditory modality

Sussman

Winkler

Schröger

2003

Psychonomic Bulletin & Review

178

201

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We tested the effects of predictability on involuntary attention switching to task-irrelevant sound changes (distraction). Behavioral and neurophysiological evidence are provided, showing that the predictability of task-irrelevantsound changes eliminates effects of distraction even though the automatic auditory change detection system remains responsive. Two indices of distraction, slower task performance and cortical brain responses associatedwith attention switching, were seen only in the unpredictable condition, in which the irrelevant acoustic changes were unexpected. Attention was not involuntarily drawn away from the primary task when the subjects had foreknowledge of when the irrelevant changes would occur. These results demonstrate attentional control over orienting to sound changes and suggest that involuntary attention switching occurs mainly when an irrelevant stimulus change is unexpected. The present data allowed observation of the temporal dynamics of attention switching in the human brain.

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Increased Distractibility by Task‐Irrelevant Sound Changes in Abstinent Alcoholics

Abstract: Attentional deficits in the abstinent alcoholics were indicated by the increased distractibility by irrelevant sound changes. The MMN enhancement suggested that this reflects impaired neural inhibition of involuntary attention shifting, being most pronounced in early-onset alcoholics.

Cited by 47 publications

References 35 publications

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult

Plasticity of Attentional Functions in Older Adults after Non-Action Video Game Training: A Randomized Controlled Trial

Top-down control over involuntary attention switching in the auditory modality

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