“…Cytokines, central mediators of the inflammatory activity of the acute phase response, have been shown to up-regulate the expression of ferritin (Konijn & Hershko, 1977;Piñero et al, 2000). Pro-inflammatory cytokines reported to have the ability to induce ferritin expression include Il-1α, Il-1β, Il-2, Il-6, tumour necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) (Miller et al, 1991;Pang et al, 1996;Rogers et al, 1990;Rogers, 1996;Stites et al, 1999;. These cytokines modulate ferritin expression by both transcriptional and translational mechanisms (Piñero et al, 2000), but largely by an increase in the rate of transcription of the ferritin genes (Miller et al, 1991;.…”