Increased circulating microparticles in women with preeclampsia

Zhang, Y.; Zhao, Cheng; Wei, Yuan; Yang, Shuo; Cui, Chanjuan; Yang, Jing; Zhang, J.; Qu, Rui

doi:10.1111/ijlh.12796

Cited by 16 publications

(15 citation statements)

References 26 publications

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“…In contrast, the positive association between WbcMVs generation and plaque formation in atherosclerosis, as well as their sharp elevation in septic shock, suggest their utility as possible disease biomarkers. Finally, they also seem to have a role on endothelium homeostasis or dysfunction related to breathing disorders and to the increased cardiovascular risk associated with the obstructive sleep apnea (OSA) and pre-eclampsia [ 122 , 123 , 124 , 125 ] ( Table 1 ).…”

Section: White Blood Cell-derived Vesiclesmentioning

confidence: 99%

Blood Cell-Derived Microvesicles in Hematological Diseases and beyond

et al. 2022

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Microvesicles or ectosomes represent a major type of extracellular vesicles that are formed by outward budding of the plasma membrane. Typically, they are bigger than exosomes but smaller than apoptotic vesicles, although they may overlap with both in size and content. Their release by cells is a means to dispose redundant, damaged, or dangerous material; to repair membrane lesions; and, primarily, to mediate intercellular communication. By participating in these vital activities, microvesicles may impact a wide array of cell processes and, consequently, changes in their concentration or components have been associated with several pathologies. Of note, microvesicles released by leukocytes, red blood cells, and platelets, which constitute the vast majority of plasma microvesicles, change under a plethora of diseases affecting not only the hematological, but also the nervous, cardiovascular, and urinary systems, among others. In fact, there is evidence that microvesicles released by blood cells are significant contributors towards pathophysiological states, having inflammatory and/or coagulation and/or immunomodulatory arms, by either promoting or inhibiting the relative disease phenotypes. Consequently, even though microvesicles are typically considered to have adverse links with disease prognosis, progression, or outcomes, not infrequently, they exert protective roles in the affected cells. Based on these functional relations, microvesicles might represent promising disease biomarkers with diagnostic, monitoring, and therapeutic applications, equally to the more thoroughly studied exosomes. In the current review, we provide a summary of the features of microvesicles released by blood cells and their potential implication in hematological and non-hematological diseases.

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Section: White Blood Cell-derived Vesiclesmentioning

confidence: 99%

Blood Cell-Derived Microvesicles in Hematological Diseases and beyond

et al. 2022

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“…Four subgroups were divided based on the cell membrane makers. Nine studies reported CD31-marked EMPs 6,8,10,14,15,17,19,27,28 , three studies reported CD62E-marked EMPs 12,15,27 , two studies reported CD144-marked EMPs 17,30 and two studies reported CD51-marked EMPs 16,29 . The pooled concentrations of CD31-marked EMPs were significantly elevated in PE patients (SMD: 2.37, 95% CI: 1.60 to 3.13, I 2 =95%, P < 0.00001), whereas CD62E-marked, CD144-marked and CD51-marked EMPs showed no significant difference [CD62E-marked EMPs (SMD: 0.67, 95% CI: -0.29 to 1.63, I 2 =89%, P = 0.17); CD144-marked EMPs (SMD: -0.37, 95% CI: -1.34 to 0.61, I 2 =75%, P = 0.46); CD51-marked EMPs (SMD: -0.30, 95% CI: -0.71 to 0.10, I 2 =0%, P = 0.15)] between PE and healthy pregnant patients (Figure 4).…”

Section: Empsmentioning

confidence: 99%

“…Nine studies 6,10,12,16,17,25,[28][29][30] reported PMPs in the third trimester. There was no significant difference between PE and healthy pregnant patients (SMD: -0.20, 95% CI: -0.54 to 0.15, I 2 =75%, P = 0.27).…”

Section: Pmpsmentioning

confidence: 99%

“…It was divided into three subgroups. Among them, four studies reported CD41-marked PMPs 10,16,17,29 , two studies reported CD42-marked PMPs 6, 28 and three studies reported CD61-marked PMPs 12,25,30 . The pooled concentrations of CD41-marked PMPs were significantly decreased in PE patients (SMD: -0.51, 95% CI: -0.76 to -0.27, I 2 =40%, P < 0.0001), whereas CD42-marked and CD61-marked PMPs showed no significant difference [CD42-marked PMPs (SMD: 0.05, 95% CI: -0.21 to 0.31, I 2 =32%, P = 0.72); CD61marked PMPs (SMD: -0.05 95% CI: -1.18 to 1.07, I 2 =87%, P = 0.93)] between PE and healthy pregnant patients.…”

Section: Pmpsmentioning

confidence: 99%

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Microparticles in Preeclampsia during Pregnancy: A Systematic Review and Meta-analysis

McClements

Guo

et al. 2022

Preprint

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Background: Preeclampsia (PE) is a severe manifestation of maternal hypertensive disease with high morbidity and mortality which microparticles (MPs) might be generated. But there is limited evidence on response MPs with PE. Objectives: To explore the relationship between MPs and PE. Search strategy: A systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines in Pubmed, Embase, Web of Science and China National Knowledge Infrastructure (inception to September 20, 2022). Selection criteria: Studies on patients diagnosed as PE were included. Studies on patients with chronic hypertension, pre-gestational diabetes mellitus, and history of recurrent pregnancy loss, renal or hepatic diseases, and antiphospholipid syndrome were excluded. Data collection and analysis: Two authors independently screened the studies, extracted the data and assessed the quality of the studies. Results were combined descriptively and analyzed using a standardized Excel form. Main results: We included 25 studies with a total of 1885 patients (862 with PE and 1023 with healthy pregnancy). Any MPs level was found no significant difference between PE and healthy pregnant patients in the second trimester. However, CD31-marked EMPs, RMPs and MPs from placenta are significantly elevated in the third trimester of preeclampsia, while CD41-marked PMPs is significantly decreased. After postpartum, tMPs and EMPs were found no significant difference between PE and healthy pregnant patients. Conclusion: MPs level is significantly associated with PE in the third trimester, but the association is dependent on its cell source and labeled marker.

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“…PE is also associated with hypercoagulability, endothelial dysfunction, and inflammation, resulting in microparticles (MPs) in which microparticles of platelets (PMPs), endothelial cells (EMPs), and leukocytes (LMPs) which are a method of knowing the presence of endothelial dysfunction and inflammation involved in the pathogenesis of PE [147]. Glomerular damage kidneys are common in PE and can be identified with tubular channels such as 1-microglobulin (A1M), retinol-binding protein (RBP), molecule-1 (KIM1), C5b-9, metalloproteinase-2 (TIMP-2), and insulin growth factors binding protein-7 (IGFBP-7) [148].…”

Section: Kidney Disease In Pementioning

confidence: 99%

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

Situmorang

Ilyas

2018

Asian J Pharm Clin Res

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Preeclampsia (PE) have a high risk of pregnancy disorder and can cause liver and kidney disease. PE is a dangerous disease in Indonesia with a high risk of cardiovascular death. PE has biomarkers such as proteinuria, blood pressure, dipstick test, renin-angiotensin system, adipsin, calcium/ creatinine (Cr) ratio, albumin/Cr ratio, and uric acid. Apoptosis occurs in the placenta’s PE, where trophoblasts invade and overhaul the uterine spiral artery in the epidermal growth factor signaling system, and the expression of miRNA in PE is targeting genes in a variety of pathophysiological processes can cause kidney and hepatic disease. In this review, we will discuss role of HSP, miRNA, Immunology cell and the risk of kidney and hepatic disease of patient of Preeclampsia.

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Increased circulating microparticles in women with preeclampsia

Abstract: Determining the MP level, especially that of EMPs and LMPs, by a specificity-verified method may reflect the endothelial dysfunction and inflammation involved in PE pathogenesis.

Cited by 16 publications

References 26 publications

Blood Cell-Derived Microvesicles in Hematological Diseases and beyond

Blood Cell-Derived Microvesicles in Hematological Diseases and beyond

Microparticles in Preeclampsia during Pregnancy: A Systematic Review and Meta-analysis

Study of Preeclampsia in Placenta, Kidney, and Hepatic Diseases

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