Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database

Minamino, Hiroto; Katsushima, Masao; Yoshida, Tamao; Hashimoto, Motomu; Fujita, Yoshihito; Shirakashi, Mirei; Yamamoto, Wataru; Murakami, Kosaku; Murata, Koichi; Nishitani, Kohei; Tanaka, Masao; Ito, Hiromu; Inagaki, Nobuya; Matsuda, Shinya

doi:10.1371/journal.pone.0229998

Cited by 22 publications

(21 citation statements)

References 39 publications

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“…However, most studies have shown a correlation of adiponectin with inflammation markers such as C-reactive protein (CRP), including a recent study showing that total and HMW adiponectin are positively correlated with CRP levels [ 47 ]. A positive correlation between serum adiponectin and the disease activity score disease activity score (DAS)28 - ESR in RA patients was shown in another cross-sectional study [ 48 ]. Interestingly, subcutaneous adipose tissue from RA patients produced more adiponectin compared to OA patients and correlated with disease activity and disease duration in these patients [ 49 ].…”

Section: Adipokines In Autoimmune Rheumatoid Arthritismentioning

confidence: 99%

Adipokines and Autoimmunity in Inflammatory Arthritis

Neumann

Hasseli

Ohl

et al. 2021

Cells

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Adipokines are adipose tissue-derived factors not only playing an important role in metabolism but also influencing other central processes of the body, such as inflammation. In autoimmune diseases, adipokines are involved in inflammatory pathways affecting different cell types. Many rheumatic diseases belong to the group of autoimmune diseases, for example rheumatoid arthritis (RA) and psoriatic arthritis. Due to the autoimmune responses, a chronic inflammatory milieu develops, which affects the whole body, including adipose tissue. Metabolic alterations such as obesity influence inflammatory responses in autoimmune diseases. Adipokines are bioactive mediators mainly produced by adipose tissue. Due to alterations of systemic adipokine levels, their role as biomarkers with diagnostic potential has been suggested in the context of rheumatic diseases. In the affected joints of RA patients, different synoviocytes but also osteoclasts, osteoblasts, and chondrocytes produce several adipokines, contributing to the unique inflammatory microenvironment. Adipokines have been shown to be potent modulatory effectors on different cell types of the immune system but also local cells in synovial tissue, cartilage, and bone. This review highlights the most recent findings on the role of adipokines in the pathophysiology of inflammatory arthritis with a distinct focus on RA in the quickly developing research field.

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Section: Adipokines In Autoimmune Rheumatoid Arthritismentioning

confidence: 99%

Adipokines and Autoimmunity in Inflammatory Arthritis

Neumann

Hasseli

Ohl

et al. 2021

Cells

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“…Rheumatoid arthritis (RA), the most common form of inflammatory arthritis, is a chronic systemic autoimmune disease characterized by aggressive symmetrical inflammation of multiple joints ( Kobayashi et al, 2010 ; Miossec, 2013 ; Minamino et al, 2020 ). Epidemiological studies have shown that about 90% of RA patients develop bone erosion within 2 years of onset, resulting in joint deformity or even disability.…”

Section: Obesity and Bone-related Diseasesmentioning

confidence: 99%

Obesity and Bone Health: A Complex Link

Hou

et al. 2020

Front. Cell Dev. Biol.

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So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health.

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“…Therefore is the observation that autologous serum eye drops can, at least temporarily, successfully be replaced by HMW HA eye drops [126] clinically important and very promising. Serum, on the other hand, is used as a diagnostic medium as it may reflect general disease [127]. Hence, pathological conditions of the patient could also alter the blood composition and possibly result in a pathological composition of the serum.…”

Section: Epithelial Lesions-the Effect Of Attritionmentioning

confidence: 99%

Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered

Setten

2020

IJMS

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The mechanical component in the pathophysiology of dry eye disease (DED) deserves attention as an important factor. The lubrication deficit induced impaired mechano-transduction of lid pressure to the ocular surfaces may lead to the dysregulation of homeostasis in the epithelium, with sensations of pain and secondary inflammation. Ocular pain is possibly the first sign of attrition and may occur in the absence of visible epithelial damage. Attrition is a process which involves the constant or repeated challenge of ocular surface tissues by mechanical shear forces; it is enhanced by the thinning of corneal epithelium in severe DED. As a highly dynamic process leading to pain and neurogenic inflammation, the identification of the impact of attrition and its potential pathogenic role could add a new perspective to the current more tear film-oriented models of ocular surface disease. Treatment of DED addressing lubrication deficiencies and inflammation should also consider the decrease of attrition in order to stimulate epithelial recovery and neural regeneration. The importance of hyaluronic acid, its molecular characteristics, the extracellular matrix and autoregulative mechanisms in this process is outlined. The identification of the attrition and recognition of its impact in dry eye pathophysiology could contribute to a better understanding of the disease and optimized treatment regimens.

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Increased circulating adiponectin is an independent disease activity marker in patients with rheumatoid arthritis: A cross-sectional study using the KURAMA database

Cited by 22 publications

References 39 publications

Adipokines and Autoimmunity in Inflammatory Arthritis

Adipokines and Autoimmunity in Inflammatory Arthritis

Obesity and Bone Health: A Complex Link

Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered

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