Increased cholesterol in plasma in a young man during experimental copper depletion

Klevay, Leslie M.; Inman, Linda; Johnson, LuAnn K.; Lawler, Marilyn R.; Mahalko, J R; Milne, David B.; Lukaski, Henry C.; Bolonchuk, William W.; Sandstead, Harold H.

doi:10.1016/0026-0495(84)90096-9

Cited by 185 publications

(58 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In parallel, changes in lipid metabolism were evident. Cholesterol was elevated in the serum, and changes in the cholesterol levels were found to be more sensitive to copper levels than changes in hematology (29). These observations suggest that the dietary copper levels may be significant modifying factors in the disorders associated with lipid misbalance.…”

Section: Low Copper and Human Diseasementioning

confidence: 83%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

View full text Add to dashboard Cite

Section: Low Copper and Human Diseasementioning

confidence: 83%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

View full text Add to dashboard Cite

“…Correspondingly, there is evidence that an inadequate Cu intake favours the development of hypercholesterolaemia. An increase in total cholesterol, LDL-cholesterol and decrease in HDL-cholesterol were observed in Cu deficiency (Klevay et al, 1984). The effect of Cu depletion in animal vessels and the changes found in patients with CHD show apparent similarities (elastin destruction, fibrosis, intramural haemorrhages, increase in mucopolysaccharides, necrosis and the proliferation of smooth muscle cells; (Klevay, 1993).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 98%

Hohenheim Consensus Workshop: Copper

Schümann¹,

Classen

Dieter

et al. 2002

Eur J Clin Nutr

View full text Add to dashboard Cite

Copper (Cu) is an essential trace element with many physiological functions. Homeostatic mechanisms exist to allow Cu to act as a cofactor in enzymatic processes and to prevent accumulation of Cu to toxic levels. The aim of this commentary is to better understand the role of dietary Cu supply in deficiency and under physiological and pathological conditions. The essentiality of Cu can be attributed to its role as a cofactor in a number of enzymes that are involved in the defence against oxidative stress. Cu, however, has a second face, that of a toxic compound as it is observed with accumulating evidence in hepatic, neurodegenerative and cardiovascular diseases. The destructive potential of Cu can be attributed to inherent physico-chemical properties.The main property is its ability to take part in Fenton-like reactions in which the highly reactive and extremely deleterious hydroxyl radical is formed. Diseases caused by dietary Cu overload could be based on a genetic predisposition. Thus, an assessment of risk-groups, such as infants with impaired mechanisms of Cu homeostasis regarding detoxification, is of special interest, as their Cu intake with resuspended formula milk may be very high. This implies the need for reliable diagnostic markers to determine the Cu status. These topics were introduced at the workshop by the participants followed by extensive group discussion. The consensus statements were agreed on by all members. One of the conclusions is that a re-assessment of published data is necessary and future research is required.

show abstract

“…The most frequent signs of Cu deficiency in human subjects are anaemia, neutropaenia (Williams, 1983) and bone abnormalities (Danks, 1988), while less frequent signs are hypopigmentation (Danks, 1988), impaired growth (Castillo-Duran & Uauy, 1988), increased incidence of infections (Castillo-Duran et al 1983), alterations of phagocytic capacity of neutrophils (Heresi et al 1985) and abnormalities of glucose (Klevay et al 1986) and cholesterol metabolism (Reiser et al 1987). Severe Cu deficiency in both animals and human subjects can be identified by low serum or plasma Cu or caeruloplasmin, low red blood cell SOD activity and neutropaenia.…”

Section: Copper Deficiencymentioning

confidence: 99%