The immune system as a physiological indicator ofmarginal copper status?

O’Connor, Jacqueline M.; Hannigan, Bernadette M.; Strain, J. J.; Bonham, Maxine P.

doi:10.1079/bjnbjn2002558

Cited by 39 publications

(4 citation statements)

References 20 publications

(29 reference statements)

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“…[260][261][262] Copper is a crucial element for an intact and robust immune system, and its deficiency has been seen to be associated with an increased rate of infections. 263 Copper has been found to modulate neutrophil, macrophage, and functioning of natural killer cell activity. Evidence shows that copper enhances T lymphocyte functioning and proliferation and helps synthesize IL-2, hence improving immunity.…”

Section: Role Of Micronutrients Vitamins and Other Trace Elements Imentioning

confidence: 99%

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The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Samad¹,

Sodunke²,

Abubakar³

et al. 2021

JIR

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The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for COVID-19 management. Also, there is an urgent need to discover effective medicines, prevention, and control methods because of the harsh death toll from this novel coronavirus infection. Acute respiratory tract infections, significantly lower respiratory tract infections, and pneumonia are the primary cause of millions of deaths worldwide. The role of micronutrients, including trace elements, boosted the human immune system and was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, and folate; microelement including zinc, iron, selenium, magnesium, and copper; omega-3 fatty acids as eicosapentaenoic acid and docosahexaenoic acid plays essential physiological roles in promoting the immune system. Furthermore, zinc is an indispensable microelement essential for a thorough enzymatic physiological process. It also helps regulate gene-transcription such as DNA replication, RNA transcription, cell division, and cell activation in the human biological system. Subsequently, zinc, together with natural scavenger cells and neutrophils, are also involved in developing cells responsible for regulating nonspecific immunity. The modern food habit often promotes zinc deficiency; as such, quite a few COVID-19 patients presented to hospitals were frequently diagnosed as zinc deficient. Earlier studies documented that zinc deficiency predisposes patients to a viral infection such as herpes simplex, common cold, hepatitis C, severe acute respiratory syndrome coronavirus (SARS-CoV-1), the human immunodeficiency virus (HIV) because of reducing antiviral immunity. This manuscript aimed to discuss the various roles played by zinc in the management of COVID-19 infection.

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Section: Role Of Micronutrients Vitamins and Other Trace Elements Imentioning

confidence: 99%

“…Figure 4Potential micronutrients effective in COVID-19. Selenium,254,[257][258][259] copper,[263][264][265][266][267] iron,[268][269][270] misc. 258,272-274 Samad et al Dovepress submit your manuscript | www.dovepress.com DovePress…”

mentioning

confidence: 99%

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Samad¹,

Sodunke²,

Abubakar³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…Although it has seen that amount of neutrophil, serum IL-2R, and the antibody titer against the Beijing strain of influenza reduce by higher intake of copper (7.8 mg/day) [23,54]. Impairment of the immune system and enhanced rate of infections has been associated with copper deficiency [55]. Chronic TNF-ɑ induced inflammation of the lungs may cause by a lack of copper [56].…”

Section: Coppermentioning

confidence: 99%

A Review on the Serum Electrolytes and Trace Elements Role in the Pathophysiology of COVID-19

Taheri

Bahrami

Habibi

et al. 2020

Biol Trace Elem Res

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All the world is involved in the COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is a positive-sense RNA and has an envelope. There is no specific drug for this disease and treatment methods are limited. Malnutrition and electrolyte imbalance can make dysfunction in the immune system and impairment of the immune system causes increasing the risk of infection. Understanding the aspects of biological features of the virus will help the development of diagnostic tests, pharmacological therapies, and vaccines. Here, we review and discuss increasing and decreasing some trace elements and imbalance of serum and plasma electrolytes involving in COVID-19.

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“…Copper (Cu), an essential trace element, is involved in many physiological processes and biological reactions, including mitochondrial respiration, antioxidant activity, and neuropeptide synthesis [1]. Previous studies have shown that Cu is a crucial cofactor for specific enzymes and electron transport proteins, which participates in energy metabolism in various animals and human beings [2,3]. Although Cu plays a key role in biological processes, it has a certain toxic with excessive ingestion [4].…”

Section: Introductionmentioning

confidence: 99%

Copper Induces Apoptosis Through Endoplasmic Reticulum Stress in Skeletal Muscle of Broilers

Guo

Bai

Liao

et al. 2020

Biol Trace Elem Res

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The purpose of this research was to investigate whether copper (Cu) exposure could induce apoptosis via endoplasmic reticulum stress (ERS) in skeletal muscle of broilers. A total of 240 one-day-old chickens were randomly divided into four groups by free access; the diets are as follows: control diet (Cu 11 mg/kg, control group) and high level of Cu diets (Cu 110 mg/kg, group I; Cu 220 mg/kg, group II; Cu 330 mg/kg, group III). The skeletal muscle tissues were collected on day 49 for further examination. The content of Cu, histopathology, and the expression levels of the genes and proteins related to ERS and apoptosis were detected. Results showed that the Cu levels in skeletal muscle were increased in a dose-dependent manner. Meanwhile, the spaces between the muscle fibers were wider with the increase of Cu content, and the myolysis was observed in group III. Besides, the mRNA expression levels of GRP78, GRP94, eIF2α, ATF6, XBP1, CHOP, Caspase-12, and Caspase3 were markedly increased in treated groups compared with control group, and the protein expression levels of GRP78, Caspase3, Active-Caspase3 and JNK were significantly elevated with the increase of dietary Cu. In summary, these findings suggested that Cu could induce apoptosis through ERS in skeletal muscle of broilers.

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The immune system as a physiological indicator ofmarginal copper status?

Cited by 39 publications

References 20 publications

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

A Review on the Serum Electrolytes and Trace Elements Role in the Pathophysiology of COVID-19

Copper Induces Apoptosis Through Endoplasmic Reticulum Stress in Skeletal Muscle of Broilers

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