Increased CA 125 serum levels in patients with advanced acute leukemia with serosal involvement

Camera, Andrea; Villa, Maria Rosaria; Rocco, Stefano; Novellis, Tiziana De; Costantini, Silvia; Pezzullo, Luca; Lucania, Anna; Mariano, Angela; Macchia, Vincenzo; Rotoli, Bruno

doi:10.1002/(sici)1097-0142(20000101)88:1<75::aid-cncr11>3.0.co;2-#

Cited by 25 publications

(27 citation statements)

References 11 publications

(10 reference statements)

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“…It has been found to be elevated in the serum of patients with ovarian carcinoma, peritoneal tuberculosis, chronic liver disease, advanced leukemia with serosal involvement, and in the patients with various gastrointestinal malignancies. [13][14][15][16][17] We did not find any information in the literature regarding the CA 125 level in the brucellosis cases. In our case, CA 125 level was elevated before treatment as much as 4.3 folds of upper limit of normal, and it returned to normal level after treatment.…”

Section: Discussionmentioning

confidence: 99%

Brucellosis Induced Ascites, Cholestasis and Elevated Serum CA 125 Level: Case Report

Kaya¹,

Beştaş²,

Cangül³

et al. 2012

Turkiye Klinikleri J Med Sci

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Section: Discussionmentioning

confidence: 99%

Brucellosis Induced Ascites, Cholestasis and Elevated Serum CA 125 Level: Case Report

Kaya¹,

Beştaş²,

Cangül³

et al. 2012

Turkiye Klinikleri J Med Sci

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“…The underlying mechanism for the production and secretion of CA125 remains largely enigmatic. It has been shown that neoplastic cells themselves do not produce CA125 [4], thus supporting the hypothesis that increased serum CA125 may represent a reaction of pleuropericardial or other mesothelial cells. In non-malignant conditions, it seems that serosal irritation due to inflammation, mechanical stress or fluid congestion stimulates mesothelial cells to release CA125 [16].…”

mentioning

confidence: 86%

“…Several studies have reported elevation of serum CA125 in other malignant diseases [3][4][5] and nonmalignant conditions [6][7][8][9][10]. Recently, increased serum CA125 values, in parallel with catecholamines and natriuretic peptides, have also been documented in patients with heart failure [11][12][13][14][15].…”

mentioning

confidence: 99%

CA125 levels among patients with advanced heart failure: An emerging independent predictor for survival

Turgut¹,

Tandoğan²,

Yilmaz³

et al. 2010

International Journal of Cardiology

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“…14) and Ca125. 15 Control and allodepleted donor (responder) cells were plated on irradiated, Ag-pulsed cells at concentrations of 10 000 to 125 cells/well for CMV-, C. albicans-, T. gondii-, HSV-, ADV-and VZV-and WT-1-and Ca125-specific responses, and at concentrations of 100 000 to 3500 for A. fumigatus-specific responses. CMV, T. gondii, HSV and ADV Ags were purchased from Microbix Biosystems Inc (Toronto, Canada).…”

Section: Photodynamic Depletion Of Alloreactive T Cellsmentioning

confidence: 99%

Optimizing a photoallodepletion protocol for adoptive immunotherapy after haploidentical SCT

Perruccio

Topini

Tosti

et al. 2011

Bone Marrow Transplant

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In adults, one-haplotype-mismatched haematopoietic SCT (haploidentical HSCT) is associated with slow immune recovery due to decaying thymic function and extensive T-cell depletion of the graft. Although essential for preventing GVHD, T-cell depletion underlies the major reasons for transplant failure: leukemia relapse and infections, with infection-related mortality accounting for about 40% of non-leukemic deaths. Adoptive T-cell therapy would be helpful for these patients but to administer it without causing GVHD, alloreactive T cells need to be eliminated from donor T lymphocytes before infusion. In a preclinical study, to address this problem, we determined the efficacy of photodynamic purging of alloreactive T cells, by investigating combinations of parameters in order to achieve maximum allodepletion, preservation of T-regulatory cells and of pathogen and leukemia-specific T-cell responses in donor-vs-recipient MLR. We also needed to identify an optimal method to quantify the Ag-specific T-cell repertoires. Optimal procedures were identified. In particular, we compared limiting-dilution analyses (LDA) of proliferating T cells with H 3 -thymidine incorporation by bulk T cells and with flow cytometry CD25 expression, which is accepted as a T-cell activation marker. This study demonstrated that LDA is a reliable, predictable and sensitive method for measuring alloreactive, pathogen-and leukemia-specific T-cell frequencies.

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Increased CA 125 serum levels in patients with advanced acute leukemia with serosal involvement

Cited by 25 publications

References 11 publications

Brucellosis Induced Ascites, Cholestasis and Elevated Serum CA 125 Level: Case Report

Brucellosis Induced Ascites, Cholestasis and Elevated Serum CA 125 Level: Case Report

CA125 levels among patients with advanced heart failure: An emerging independent predictor for survival

Optimizing a photoallodepletion protocol for adoptive immunotherapy after haploidentical SCT

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