CA125 levels among patients with advanced heart failure: An emerging independent predictor for survival

Plasma CA-125 level is related to both sides of the heart: A retrospective analysis

“…CA-125 could be an emerging marker of poor survival in this group of patients [13]. In our study, including not only systolic HF patients but all patients with available result, CA-125 levels were correlated with left ventricular EF, SPAP, and associated with the presence of pericardial effusion, RV and RA dilatations.…”

Antigen carbohydrate 125 and brain natriuretic peptide serial measurements for risk stratification following an episode of acute heart failure

“…Tumor marker antigen carbohydrate 125 (CA125) has been shown to correlate with parameters of disease severity and to be independently associated with clinical outcomes in patients with AHF; [9][10][11][12][13][14][15][16] Along this line, our group has observed that CA125 added prognostic value beyond the information provided by BNP in patients admitted for AHF [11]. Moreover, some authors have reported fluctuations in the level of this biomarker in response to treatment and paralleling the clinical status [10,12].…”

CA125 and immunoinflammatory activity in acute heart failure

“…Moreover, CA125 was associated with increased 6-month mortality independently of evidence of fluid overload, leading us to conclude that in addition of being a surrogate for systemic fluid congestion, its elevation may also be an indication for its involvement in other pathogenic processes. Turgut et al, in a recent letter [8], proposed that increased ventricular wall stress with concomitant overexpression of some cytokines would lead to an increased secretion of CA125 by mesothelial cells. Within the same line of thinking, Kosar et al reported in a case-control study, that CA125 was highly correlated with tumour necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in 35 hospitalized HF patients with left ventricular systolic dysfunction [9].…”