Plasma CA-125 level is related to both sides of the heart: A retrospective analysis

Yilmaz, Mehmet Birhan; Zorlu, Ali; Tandoğan, İzzet

doi:10.1016/j.ijcard.2009.12.003

Cited by 48 publications

(45 citation statements)

References 16 publications

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“…In studies related to HF, CA-125 values correlated with pulmonary artery pressure, pulmonary artery capillary wedge pressure, left atrial volume index, LVEF, brain natriuretic peptide values, New York Heart Association functional class, and pericardial effusion. 14,15,17 In our study, CA-125 values correlated with SPAP, LVEF, and pericardial effusion.…”

Section: Discussionsupporting

confidence: 52%

“…It is not surprising, therefore, to find that AF, in the current study, is an independent predictor for prolonged hospitalization in patients with HF. 14,17,19,43,44 In addition to high CA-125 levels and the presence of AF, lower sodium levels and higher creatinine levels are associated with prolonged LOS. This result, consistent with previous studies, is not surprising.…”

Section: Discussionmentioning

confidence: 99%

“…11 However, in the last decade, a correlation between serum CA-125 levels and cardiopulmonary diseases such as left-and rightsided HF, coronary artery disease, atrial fibrillation (AF), and chronic obstructive pulmonary disease (COPD), has been revealed. [12][13][14][15][16][17][18][19] Although serum CA-125 levels are significantly increased in HF and this increase correlates with the severity of the disease, the relationship between CA-125 and length of stay (LOS) in patients with HF has not yet been evaluated. This study is the first that attempts to evaluate the relationship between the duration of hospitalization and CA-125 levels in patients with HF.…”

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confidence: 99%

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Cancer Antigen 125 is Associated with Length of Stay in Patients with Acute Heart Failure

Kaya¹,

Kurt²,

Beton³

et al. 2017

Texas Heart Institute Journal

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Length of stay is the primary driver of heart-failure hospitalization costs. Because cancer antigen 125 has been associated with poor morbidity and mortality rates in heart failure, we investigated the relationship between admission cancer antigen 125 levels and lengths of stay in heart-failure patients. A total of 267 consecutive patients (184 men, 83 women) with acute decompensated heart failure were evaluated prospectively. The median length of stay was 4 days, and the patients were classified into 2 groups: those with lengths of stay ≤4 days and those with lengths of stay >4 days. Patients with longer lengths of stay had a significantly higher cancer antigen 125 level of 114 U/mL (range, 9–298 U/mL) than did those with a shorter length of stay (19 U/mL; range; 3–68) (P <0.001). The optimal cutoff level of cancer antigen 125 in the prediction of length of stay was >48 U/mL, with a specificity of 95.8% and a sensitivity of 96% (area under the curve, 0.979; 95% confidence interval [CI], 0.953–0.992). In the multivariate logistic regression model, cancer antigen 125 >48 U/mL on admission (odds ratio=4.562; 95% CI, 1.826–11.398; P=0.001), sodium level (P<0.001), creatinine level (P=0.009), and atrial fibrillation (P=0.015) were also associated with a longer length of stay after adjustment for variables found to be statistically significant in univariate analysis and correlated with cancer antigen 125 level. In addition, it appears that in a cohort of patients with acute decompensated heart failure, cancer antigen 125 is independently associated with prolonged length of stay.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Cancer Antigen 125 is Associated with Length of Stay in Patients with Acute Heart Failure

Kaya¹,

Kurt²,

Beton³

et al. 2017

Texas Heart Institute Journal

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“…34 In another recent study, CA 125 levels correlated with LVEF and were associated with the presence of pericardial effusion and RV and RA dilatations. 35 In their multiple regression analysis, the CA 125 level was independently associated with RV dilatation, pericardial effusion and LVEF. 35 To our knowledge, this study is the first to examine the relationship between serum CA 125 levels and LV hypertrophy and the level of systolic dysfunction in HD patients.…”

Section: Discussionmentioning

confidence: 97%

“…35 In their multiple regression analysis, the CA 125 level was independently associated with RV dilatation, pericardial effusion and LVEF. 35 To our knowledge, this study is the first to examine the relationship between serum CA 125 levels and LV hypertrophy and the level of systolic dysfunction in HD patients. In this study, we detected elevated CA 125 levels in HD patients with low LVEF and increased LV dimensions.…”

Section: Discussionmentioning

confidence: 97%

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

et al. 2013

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Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 AE 35.48 U/ mL, was significantly higher than that found in healthy controls (9.20 AE 4.55 U/mL; p ¼ 0.003). Patients with elevated CA 125 levels (n ¼ 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r ¼ 0.596, p50.05) and C-reactive protein (CRP) levels (r ¼ 0.439, p50.05), as well as LVEDd (r ¼ 0.599, p50.001), LVESd (r ¼ 0.750, p50.001) and LV mass index (r ¼ 0.378, p50.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r ¼ À0.513, p50.05) and hemoglobin (r ¼ À0.475, p50.05) as well as the EF (r ¼ À0.878, p50.0001). A depressed EF ( ¼ À1.121, p50.0001) and increased CRP levels ( ¼ 0.247, p ¼ 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.

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Role of CA‐125 in Identification of Right Ventricular Failure in Chronic Obstructive Pulmonary Disease

Yilmaz¹,

Zorlu²,

Doǧan

et al. 2011

Clinical Cardiology

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Background: Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating disease. Cor pulmonale, characterized by right ventricular (RV) failure, can severely influence prognosis in these patients. Hence, early recognition might be important for tailoring therapy. An old biomarker, CA-125, seems to be associated with the right heart. We aimed to show the relationship between CA-125 levels and RV failure in patients with COPD. Hypothesis: CA-125 might be a useful biomarker in identification of RV failure in patients with COPD. Methods: Forty patients with recent exacerbation of COPD were enrolled into the study. Another 40 age-and sex-matched individuals were enrolled for comparison. Levels of CA-125 were measured in the patients during the hospital stay. The COPD patients underwent echocardiographic study on the same day. Right-ventricular parameters were evaluated, and RV failure was identified via transthoracic echocardiography. Results: Patients with COPD had significantly higher CA-125 levels compared with controls (median 33.94 U/mL vs 9.76 U/mL, respectively; P < 0.001). Levels of CA-125 were correlated with systolic pulmonary artery pressure (r = 0.550, P < 0.001), tricuspid annular plane systolic excursion (r = −0.496, P = 0.001), and tricuspid lateral annulus S velocity (r = −0.549, P = 0.002). High CA-125 levels, obtained in hospitalized patients with COPD before echocardiography, enabled identification of RV failure with a sensitivity of 89.5% and specificity of 85.7%. Conclusions:The CA-125 biomarker can be used to identify COPD patients with RV failure.

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Plasma CA-125 level is related to both sides of the heart: A retrospective analysis

Cited by 48 publications

References 16 publications

Cancer Antigen 125 is Associated with Length of Stay in Patients with Acute Heart Failure

Cancer Antigen 125 is Associated with Length of Stay in Patients with Acute Heart Failure

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

Role of CA‐125 in Identification of Right Ventricular Failure in Chronic Obstructive Pulmonary Disease

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