Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation

Campo, Andrea del; Roldán, Juan; Verdejo, Hugo; Zalaquett, Ricardo; Becerra, Elia; Navarro-Márquez, Mario; Mellado, Rosemarie; Lavandero, Sergio; Corbalán, Ramón; Garcı́a, Lorena; Chiong, Mario

doi:10.1016/j.jjcc.2017.03.011

Cited by 10 publications

(9 citation statements)

References 53 publications

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“…Whole inflammatory cascade, including IL-6, must be prompted to induce AF. Additionally, a recent study concluded that higher CRP levels might be associated with gene polymorphisms rather than increased inflammation [Del Campo 2017]. Since we included patients with recent acute coronary syndrome, CRP levels might be higher compared to other studies.…”

Section: Discussionmentioning

confidence: 90%

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Comparison of SYNTAX Score I and SYNTAX Score II for Predicting Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery

Öztürk

Kalyoncuoğlu²,

Şahın³

2019

HSF

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Background: Atrial fibrillation is a frequent cause of morbidity following coronary artery bypass grafting (CABG). SYNTAX score II (SSII) is associated with outcomes in patients undergoing coronary revascularization. We investigated the relationship between SSII and postoperative atrial fibrillation (POAF) in patients undergoing CABG. Methods: Records of 461 consecutive patients who underwent elective isolated CABG were retrospectively reviewed. Characteristics of patients with and without POAF were compared. Results: POAF developed in 51 (11.1%) patients. Patients with POAF were older (61.8 ± 7.8 versus 58.4±7.7; P = .003). Chronic obstructive pulmonary disease (COPD) and history of coronary artery disease (CAD) were more frequent in patients with POAF whereas the frequency of hypertension (HT), diabetes mellitus (DM), and smoking did not differ. CRP was significantly higher in patients with POAF. Left atrial diameter (LAD), EuroSCORE II, SSI and SSII were greater in patients with POAF (P < .001 for all). Age, history of CAD, LAD, SSI, and SSII were independent predictors of POAF in multivariate regression analysis. In ROC analysis, SSII was more accurate than SSI for predicting POAF, albeit statistically insignificant [difference between AUC: 0.0483, 95% CI (-0.0411) - (0.138); z statistic:1.059, P = .29)]. In-hospital MACE (3.2% versus 9.8%, P = .038) and one-year mortality (4.6% versus 13.5%, P = .008) of patients with POAF were significantly higher. Conclusion: POAF occurred in more than one-tenth of patients undergoing CABG, and it is associated with in-hospital MACE and one-year mortality. Age, history of CAD, LAD, SSI, and SSII are independent predictors of POAF. SSII seems to be more accurate than SSI for predicting POAF.

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Section: Discussionmentioning

confidence: 90%

“…Inflammation has a substantial role in atrial fibrillation as many studies obviously demonstrated the link [Harada 2015]. CRP as a marker of inflammation seems questionable due to controversial findings of different studies [Erdem 2014;Del Campo 2017]. CRP is not a reliable marker since affected by numerous factors.…”

Section: Discussionmentioning

confidence: 99%

Comparison of SYNTAX Score I and SYNTAX Score II for Predicting Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery

Öztürk

Kalyoncuoğlu²,

Şahın³

2019

HSF

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“…Risk factors for Af are diverse and include advancing age, male gender, diabetes mellitus, cardiovascular disease, post-cardiac surgery, some biomarkers, genetics, etc. [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Late onset of atrial fibrillation in patients undergoing mitral valve repair for type II dysfunction

Kawamoto

Fujita

Fukushima

et al. 2018

Journal of Cardiology

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“…Hence, implementing preventive measures against postoperative lung infections, such as continuous low-ow oxygen inhalation, may reduce POAF. However, this assertion has taken issue with some scholars [23] . In our study, we found pulmonary infection was the most frequent postoperative complication, accounting for 72.2% (70/97) of all cases, and it was signi cantly associated with the development of POAF (P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Analysis of Postoperative Atrial Fibrillation in Video-assisted thoracoscopic surgery for Non-Small Cell Lung Cancer Resection

Ruan,

Han,

Yang

et al. 2023

Preprint

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Objective: Postoperative atrial fibrillation ( POAF ) is a frequent complication after lung cancer resection. To identify potential intervention targets, this study aimed to analyze risk contributing factors to the development of POAF in patients undergoing video-assisted thoracoscopic surgery ( VATS ) for non-small cell lung cancer ( NSCLC ) resection. Methods: A retrospective analysis was performed on a cohort of patients who underwent VATS for NSCLC resection at our hospital between January 2016 to October 2019. Patient demographics, preoperative data, and postoperative outcomes were collected and reviewed. Univariate and multivariate analyses were performed to identify significant risk factors for POAF. Results: Among 276 patients who underwent VATS for NSCLC, 29 ( 10.5 % ) developed POAF during hospitalization, and there were no deaths during hospitalization. 25 cases ( 86.2 % ) of POAF occurred within the first three days after surgery. The study established a cut-off age of 73 years, and when patients ' age exceeded this threshold. The incidence of POAF was significantly higher compared to the n-POAF group ( [ 10 ( 34.5 % ) vs. 46 ( 18.6 % ), P = 0.045 ] ). In addition, compared to the n-POAF group, the mediastinal lymph nodes retrieved and node stations explored were significantly higher in the POAF group ( [ median nodes: 10 ( 5,14 ) vs. 6 ( 0,11 ), P = 0.011; median node stations : 3 ( 3, 4 ) vs. 3 ( 0, 3 ), P = 0.005 ). Moreover, the POAF group had higher intraoperative bleeding volume [ 100 ( 50,100 ) vs. 100 ( 100, 200 ) ]. P = 0.034 ] ) and postoperative pulmonary infections ( [ 15 ( 51.7 % ) vs. 55 ( 22.3 % ). The study also identified a significant difference in preoperative hemoglobin levels between the POAF and n-POAF groups ( [ ( 117.63 ± 19.79 ) vs. ( 125.06 ± 16.30 ), P = 0.024] ). Compared to the n-POAF group, the postoperative hospitalization and drainage time were significantly longer in the POAF group ( [ postoperative hospitalization: 11 ( 9, 14 ) vs. 9 ( 6, 12 ), P = 0.024; drainage time: 7 ( 5, 9 ) vs. 5 ( 4, 8 ), P = 0.011 ). Multivariate analysis indicated that postoperative pulmonary infection ( OR: POAF group / n-POAF group = 0.349; 95 % CI 0.149-0.821 ) was an independent risk factor for POAF following VATS for NSCLC. Conclusion: Our study revealed that pulmonary infection was one of the independent risk factors for POAF following VATS in patients with NSCLC. Furthermore, POAF is associated with prolonged drainage time and extended postoperative hospitalization.

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Increased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation

Abstract: These results suggest that increased CRP plasma levels that are not associated with an inflammatory process are not sufficient to trigger AF after cardiac surgery.

Cited by 10 publications

References 53 publications

Comparison of SYNTAX Score I and SYNTAX Score II for Predicting Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery

Comparison of SYNTAX Score I and SYNTAX Score II for Predicting Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery

Late onset of atrial fibrillation in patients undergoing mitral valve repair for type II dysfunction

Risk Factors Analysis of Postoperative Atrial Fibrillation in Video-assisted thoracoscopic surgery for Non-Small Cell Lung Cancer Resection

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