Increased brain entropy of resting-state fMRI mediates the relationship between depression severity and mental health-related quality of life in late-life depressed elderly

Lin, Chia Wei; Lee, Shwu-Hua; Huang, Chih-Mao; Chen, Guan Yen; Ho, P Shing; Liu, Ho Ling; Chen, Yao Liang; Lee, Tatia Mei Chun; Wu, Shun Chi

doi:10.1016/j.jad.2019.03.012

Cited by 48 publications

(41 citation statements)

References 74 publications

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“…Depression in the elderly can often manifest itself with forgetfulness, attention loss, physical complaints and over-dealing with them, agitation, irritability. Depression disrupts patient's general health, reduces the quality of life, creates burden for their relatives (20)(21)(22). We found that 38.4% of the patients admitted to our outpatient clinic had MDD.…”

Section: Discussionmentioning

confidence: 76%

Ayaktan Tedavi Gören Yaşlı Hastalarda Psikiyatrik Bozukluk Dağılımının Değerlendirilmesi: Zor Bir Hasta Grubu

2020

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Yaşlı nüfus giderek artmaktadır ve bu artışın yakın gelecekte daha belirgin olması beklenmektedir. Yaşlı nüfusun artması ile birlikte ortaya çıkacak tıbbi, psikiyatrik ve sosyal sağlık sorunları sağlık hizmetlerine artan bir ihtiyaca neden olacaktır. Bu araştırmanın amacı, genel psikiyatri polikliniğine başvuran hastalar arasında, yaşlı hastalardaki psikiyatrik bozukluk sıklığını, cinsiyete dayalı farklılıkları ve demografik özelliklerini değerlendirmektir. Gereç ve Yöntem: Nisan 2018 ile Temmuz 2018 tarihleri arasında üniversite hastanemizin genel psikiyatri polikliniğine başvuran yaşlı (≥65 yaş) hastaların verileri kullanılarak yapılan prospektif bir çalışmadır. Klinik tanı DSM-5 kriterlerine göre konulmuştur. Hastaların demografik özellikleri kaydedilmiş ve değerlendirilmiştir. Bulgular: Genel psikiyatri polikliniğine başvuran hasta sayısı 1950 idi ve yaşlı psikiyatrik hastalar (≥65 yaş) toplam başvuruların %10.4'ünü (n=203) oluşturmaktaydı. Yaşlı hasta grubunda kadın/erkek oranı 1.44 (n=120/83) idi. En sık görülen psikiyatrik bozukluk major depresif bozukluk (MDB)'tu (%38.40). Genelleşmiş anksiyete bozukluğu (GAB) %18.70, uyum bozukluğu (UB) %9.30, şizofreni (%7.30) geropsikiyatrik hasta grubunda diğer sık görülen bozuklukları oluşturmaktaydı. GAB oranı kadınlarda, UB oranı erkeklerde istatistiksel olarak anlamlı derecede yüksek bulunmuştur. Sonuç: Yaşlı hastalarda görülen psikiyatrik bozuklukların sıklığının belirlenmesi ve cinsiyetler arasındaki farklılıkların bilinmesi tedavi stratejilerinin planlanması ve geliştirilmesine katkı sağlayacaktır.

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Section: Discussionmentioning

confidence: 76%

Ayaktan Tedavi Gören Yaşlı Hastalarda Psikiyatrik Bozukluk Dağılımının Değerlendirilmesi: Zor Bir Hasta Grubu

2020

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“…The fMRI is a non-invasive test, and it can clearly show the brain area we want to observe (48). It is often used in depression or subthreshold depression studies to determine the efficacy (49,50). Therefore, if the participants choose to perform fMRI, fMRI will be performed in the resting state before the treatment and at the sixth week of treatment (38).…”

Section: Discussionmentioning

confidence: 99%

Effect of Electroacupuncture and Counseling on Sub-Threshold Depression: A Study Protocol for a Multicenter Randomized Controlled Trial

et al. 2020

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Background: Sub-threshold depression is common and could impair function, as well as increase the risk of developing major depression. Despite evidence of efficacy for electroacupuncture (EA) and counseling in the treatment of sub-threshold depression, the sample size is insufficient and the level of evidence remains low. This study aims to evaluate the effectiveness of sub-threshold depression treatments by comparing the treatment effects among EA, counseling, and combination therapy, as well as to further study their mechanism. Methods: This study is a multicenter, randomized, single blind clinical trial that will be conducted in settings at four clinical centers in China. The randomized controlled trial (RCT) will examine the effectiveness of EA intervention, compared with counseling and combination therapy. A total of 138 sub-threshold depression patients (18 to 55 years of age with Beck Depression Inventory (BDI-II) score ≥ 14 points and Hamilton Depression Scale (HAMD-17) score: 7 points ≤ HAMD total score <17 points) will be recruited. The participants will be randomly assigned to receive the above treatments. The interventions will be delivered over a 6-week period (EA: 3 times a week for 6 weeks; 30 min a session. Counseling: once a week for 6 weeks; 50-60 min a session). The primary outcome measure will be the HAMD-17; BDI-II. The secondary outcome measures will be: Selfrating Depression Scale (SDS), Self-rating Anxiety Scale (SAS), and Pittsburgh Sleep Quality Index (PSQI). The assessments will occur at baseline, 2, 4, and 6 weeks and a follow-up period. Recruitment will commence in March 2020 and is anticipated to occur over a 2-year period.

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“…As suggested by baseline measures, the IPL and caudate clearly play a role in disturbed cognitive processes in MDD. Elevated activity in the caudate nucleus, as found in our data, together with its association with cognition may suggest neural compensatory mechanisms that have been frequently implied in MDD (Lin et al ., 2019; Garrett et al ., 2011). Yet, in the absence of an active task, this notion is preliminary and awaits extension by task-based fMRI data.…”

Section: Discussionmentioning

confidence: 99%

Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression

et al. 2019

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BackgroundCognitive impairment is a core feature of major depressive disorder (MDD). Cognitive remediation may improve cognition in MDD, yet so far, the underlying neural mechanisms are unclear. This study investigated changes in intrinsic neural activity in MDD after a cognitive remediation trial.MethodsIn a longitudinal design, 20 patients with MDD and pronounced cognitive deficits and 18 healthy controls (HC) were examined using resting-state functional magnetic resonance imaging. MDD patients received structured cognitive remediation therapy (CRT) over 5 weeks. The whole-brain fractional amplitude of low-frequency fluctuations was computed before the first and after the last training session. Univariate methods were used to address regionally-specific effects, and a multivariate data analysis strategy was employed to investigate functional network strength (FNS).ResultsMDD patients significantly improved in cognitive function after CRT. Baseline comparisons revealed increased right caudate activity and reduced activity in the left frontal cortex, parietal lobule, insula, and precuneus in MDD compared to HC. In patients, reduced FNS was found in a bilateral prefrontal system at baseline (p < 0.05, uncorrected). In MDD, intrinsic neural activity increased in right inferior frontal gyrus after CRT (p < 0.05, small volume corrected). Left inferior parietal lobule, left insula, left precuneus, and right caudate activity showed associations with cognitive improvement (p < 0.05, uncorrected). Prefrontal network strength increased in patients after CRT, but this increase was not associated with improved cognitive performance.ConclusionsOur findings support the role of intrinsic neural activity of the prefrontal cortex as a possible mediator of cognitive improvement following CRT in MDD.

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Increased brain entropy of resting-state fMRI mediates the relationship between depression severity and mental health-related quality of life in late-life depressed elderly

Cited by 48 publications

References 74 publications

Ayaktan Tedavi Gören Yaşlı Hastalarda Psikiyatrik Bozukluk Dağılımının Değerlendirilmesi: Zor Bir Hasta Grubu

Ayaktan Tedavi Gören Yaşlı Hastalarda Psikiyatrik Bozukluk Dağılımının Değerlendirilmesi: Zor Bir Hasta Grubu

Effect of Electroacupuncture and Counseling on Sub-Threshold Depression: A Study Protocol for a Multicenter Randomized Controlled Trial

Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression

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