Effect of Electroacupuncture and Counseling on Sub-Threshold Depression: A Study Protocol for a Multicenter Randomized Controlled Trial

Wang, Xiaotong; Lin, Haibiao; Jiang, Xiumin; Ma, Min-na; Shi, Dongyan; Fan, Chun; Yin, Shen; Wu, Shengwei; Yu, Lin; Li, Danian; He, Jun; Chen, Yongjun

doi:10.3389/fpsyt.2020.00346

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…It has been widely used to treat different psychiatric conditions, including depressive disorder (14,15,34). To date, few studies have investigated acupuncture for subthreshold depression (18,35). The main principles for the treatment of depression in the theory of traditional Chinese medicine are tranquilize the mind and disperse stagnated hepatoqi.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for Subthreshold Depression: Study Protocol for a Randomized Controlled Trial

et al. 2022

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BackgroundSubthreshold depression refers to a state of mental sub-health that has depressive symptoms but does not meet the diagnostic criteria for major depressive disorder. It is a strong risk factor for depression and is related to an increase in suicide and mortality. Studies suggest that acupuncture may be effective in the treatment of subthreshold depression, but no evidence has proven that the efficacy of acupuncture for subthreshold depression is a specific therapeutic effect or a placebo effect.MethodsThis will be a prospective, randomized, controlled, and double-blind study of 64 patients with subthreshold depression. They will be randomly assigned as verum or minimal acupuncture group members. Patients in the verum acupuncture group will receive acupuncture at the acupoints, and those in the minimal acupuncture group will receive minimal acupuncture at non-acupoints. The interventions will be delivered over an 8-week period. The primary outcome measure will be the Hamilton Depression Scale-17 (HAMD-17). The secondary outcome measures will be the 9-item Patient Health Questionnaire (PHQ-9), 7-item Generalized Anxiety Disorder (GAD-7), and SF-12v2 Health Survey. The assessments will occur at baseline, 4 weeks, 8 weeks, and during a follow-up period.DiscussionThe protocol uses a randomized controlled trial to examine the effectiveness of acupuncture for subthreshold depression and to further study the mechanisms of its effect.

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Section: Discussionmentioning

confidence: 99%

Acupuncture for Subthreshold Depression: Study Protocol for a Randomized Controlled Trial

et al. 2022

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“…1 Music, massage, and acupuncture have also been proven to be effective in the treatment of depression. [5][6][7][8][9] Several interventions have been evaluated individually or in comparison using randomized controlled trials. 5,[10][11][12][13] However, there are only a few studies comparing the efficacy of multiple non-pharmacological interventions in network meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Music, Massage, Exercise, or Acupuncture in the Treatment of Depression Among College Students: A Network Meta-Analysis

Li,

Lu,

et al. 2023

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To assess the therapeutic impacts of exercise, massage, and music interventions on college students experiencing depression by employing a mesh meta-analysis approach. This research intends to offer valuable insights to aid in the development of non-pharmaceutical treatment strategies for depression. Methods: We conducted a thorough search across various databases including Cochrane, PubMed, Embase, Web of Science, CNKI, and Wanfang to explore the effects of music, massage, aerobic exercise, fitness Qigong, yoga, tai chi, ball games, strength training, dance, whole body vibration training, and high-intensity interval training on the treatment of depression in college students. The search period was from January 1, 2023, which marks the establishment of each database. Subsequently, a mesh meta-analysis was performed using the "Stata 15.1" software, incorporating outcome indicators from 24 included literature comprising a total of 1458 patients. Results: Based on the ranking of the optimal intervention effects of various non-pharmaceutical methods, the order, from highest to lowest probability, was as follows: high-intensity interval training (96%), yoga (94.90%), dance (78.30%), music (73.30%), ball games (62.50%), strength training (51.70%), aerobic training (45.30%), tai chi (35.40%), vibration training (27.30%), massage (20.10%), qigong (14.30%), and no intervention (1.00%). This ranking aligns closely with the findings obtained from pairwise comparisons between different interventions. Conclusion: High-intensity interval training is likely to yield the most effective therapeutic results for college students with depression. In the pairwise comparison of different interventions, High-intensity interval training is also better than most interventions. However, to establish its intervention effect more conclusively, further validation through additional high-quality randomized controlled trials is necessary.

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“…Subclinical depression has a higher incidence in the general population. The rate of subclinical depression can reach up to 17% in the primary care and community setting ( 3 , 4 ). Moreover, the rate for the high school students is 22.9%, while that for the college students have reached 36.56%.…”

Section: Introductionmentioning

confidence: 99%

Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

et al. 2022

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Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining mental health and resistance to stress, and omega-3 PUFAs supplementation can display beneficial effects on both the prevention and treatment of depressive disorders. Although the underlying mechanisms are still unclear, accumulated evidence indicates that omega-3 PUFAs can exhibit pleiotropic effects on the neural structure and function. Thus, they play fundamental roles in brain activities involved in the mood regulation. Since depressive symptoms have been assumed to be of central origin, this review aims to summarize the recently published studies to identify the potential neurobiological mechanisms underlying the anti-depressant effects of omega-3 PUFAs. These include that of (1) anti-neuroinflammatory; (2) hypothalamus-pituitary-adrenal (HPA) axis; (3) anti-oxidative stress; (4) anti-neurodegeneration; (5) neuroplasticity and synaptic plasticity; and (6) modulation of neurotransmitter systems. Despite many lines of evidence have hinted that these mechanisms may co-exist and work in concert to produce anti-depressive effects, the potentially multiple sites of action of omega-3 PUFAs need to be fully established. We also discussed the limitations of current studies and suggest future directions for preclinical and translational research in this field.

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Effect of Electroacupuncture and Counseling on Sub-Threshold Depression: A Study Protocol for a Multicenter Randomized Controlled Trial

Cited by 5 publications

References 54 publications

Acupuncture for Subthreshold Depression: Study Protocol for a Randomized Controlled Trial

Acupuncture for Subthreshold Depression: Study Protocol for a Randomized Controlled Trial

Effects of Music, Massage, Exercise, or Acupuncture in the Treatment of Depression Among College Students: A Network Meta-Analysis

Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

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