“…Elevated BMI (Ho et al, 2010;Raji et al, 2010) and obesity (Gunstad et al, 2009;Yokum et al, 2012) have been associated with reduced total GMV; however, body mass has been consistently unrelated to global mean CT. Local GMV reductions have been observed in the OFC and the anterior cingulate cortex with increasing BMI (Raji et al, 2010), and decreased posterior parietal and temporal volumes have been reported in overweight adults (Gunstad et al, 2009;Walther et al, 2009). Studies examining local CT alterations have primarily shown BMI-related thinning in the left inferior parietal cortex, the inferior temporal and insular cortex (Hassenstab et al, 2012;Veit et al, 2014), and the prefrontal cortex, including ventromedial (Medic et al, 2016), superior frontal and orbitofrontal (Marqués-Iturria et al, 2013) regions. Although the structural correlates of neurocognitive phenotypes in obesity remain poorly characterised, reduced thickness in the superior frontal gyrus has been related to poorer performance on an inhibitory control task and higher BMI (Lavagnino et al, 2016).…”