Increased attention‐deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use

Schmitt, Jochen; Buske‐Kirschbaum, Angelika; Tesch, Falko; Trikojat, Katharina; Stephan, V.; Abraham, Susanne; Bauer, Andrea; Nemat, Katja; Plessow, Franziska; Roessner, Veit

doi:10.1111/all.13326

Cited by 53 publications

(53 citation statements)

References 64 publications

(73 reference statements)

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“…Overall, there is increasing evidence that AE is more than a skin disease and may be associated with several, non‐atopic comorbidities. One might speculate that itch, skin pain and sleep disturbances in combination with typical AE skin lesions, cause psychologic distress which may result in development of depression, anxiety and/or impaired QoL . There is still debate whether the depressive and anxious symptoms result from physical discomfort and psychosocial burden of the skin disease or whether these disorders are based on shared inflammatory pathomechanisms …”

Section: Discussionmentioning

confidence: 99%

Depression, anxiety and quality of life in subjects with atopic eczema in a population‐based cross‐sectional study in Germany

Treudler¹,

Zeynalova

Riedel-Heller

et al. 2020

Acad Dermatol Venereol

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Background Atopic eczema (AE) may be associated with several mental health problems. In Germany, existing data from selected patient cohorts may lead to misestimation of the problem. Objectives We aimed to cross‐sectionally determine associations of AE with depression, anxiety, quality of life (QoL) and social interactions in subjects from the population‐based LIFE‐Adult‐Study. Methods Subjects underwent standardized interviews (medical history) and answered standardized questionnaires [Centre of Epidemiologic studies‐Depression scale (CES‐D), Generalized Anxiety Disorder (GAD‐7), Lubben Social Network Scale (LSNS), Short Form Health Survey (SF‐8)]. We compared data from subjects with AE with those from subjects with selected other chronic/disabling diseases (cardiovascular, diabetes, cancer) and adjusted for selected sociodemographic parameters. Multivariate binary logistic regression was used for categorical variables, linear regression for continuous variables. Results Out of 9104 adults included (57% female, median age 54 years), 372 (4.1%) had a history of AE. Compared with controls, subjects with AE showed higher scores for depressive symptoms (9.3% vs. 6.3%; P < 0.001) and anxiety (8.4% vs. 5.6%, P < 0.001). Odds ratio (OR) was 1.5 [CI 1.0; 2.3] (P = 0.031) for depression, which was comparable to OR in patients with a history of cancer (OR 1.6 [1–2.3], P = 0.001. OR for anxiety in AE was 1.5 [1.0; 2.2], P < 0.049, which was slightly higher than in diabetes mellitus (OR 1.2) and stroke (OR 1.4). Other than in diabetes and/or stroke, we did not find a significant association between AE and social isolation. QoL scores were lower in AE than in controls (mean 46.9 vs. 48.0, P < 0.001 for physical and 50.6 vs. 52.5, P < 0.001 for mental components). Conclusions Subjects with AE showed higher values for depression and anxiety as well as lower QoL scores compared to controls. With regard to depression, odds in AE and cancer were hardly different. Medical care of AE patients should therefore include mental health evaluation and treatment if indicated.

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Section: Discussionmentioning

confidence: 99%

Depression, anxiety and quality of life in subjects with atopic eczema in a population‐based cross‐sectional study in Germany

Treudler¹,

Zeynalova

Riedel-Heller

et al. 2020

Acad Dermatol Venereol

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“…There is, however, no recommendation for systemic treatment with AH within the first year of life. In a small retrospective study of children with AD, we recently observed a significant association of history of antihistamine use and increased risk of ADHD symptoms 2 . The objective of the present study was to analyze whether AH exposure within the first 2 years of life represents an independent risk factor for the development of ADHD in children with AD.…”

Section: Total No Ah1 Ah1a (<2 Y Of Age)mentioning

confidence: 91%

ADHD in school‐age children is related to infant exposure to systemic H1‐antihistamines

Fuhrmann

Tesch

Romanos

et al. 2020

Allergy

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“…The likelihood of developing ADHD increased with each AD‐related doctor’s visit . A prospective, non‐interventional study has suggested that the risk of developing ADHD increases with the use of antihistamines in early childhood . Moreover, it has been shown that children with AD significantly more often exhibit oppositional defiant behavior and autism spectrum disorders ; the longer AD persists, the greater is the association with mental health problems .…”

Section: Attention‐deficit/hyperactivity Disorder (Adhd) (Table )mentioning

confidence: 99%

Atopic dermatitis and psychosocial comorbidities

Kage¹,

Simon²,

Treudler³

2020

J Deutsche Derma Gesell

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Summary Atopic dermatitis (AD) is a chronic inflammatory disease that may be associated with a number of comorbidities including psychosocial disorders, which are the primary focus of this article. The data presented is based on a literature search in PubMed and subsequent screening of relevant review articles and guidelines. There is a greater prevalence of depression, anxiety, sleep disorders and suicidal ideation among individuals with AD. The disease negatively impacts patients’ quality of life. Children with AD have been shown to more commonly exhibit signs of attention‐deficit/hyperactivity disorder. Only little data exists on the association of AD with schizophrenia, eating disorders or obsessive‐compulsive disorder. There is a great need for research in the field of AD‐related comorbidities, especially with respect to the question as to whether and how novel treatment options may potentially affect these comorbidities.

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Increased attention‐deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use

Cited by 53 publications

References 64 publications

Depression, anxiety and quality of life in subjects with atopic eczema in a population‐based cross‐sectional study in Germany

Depression, anxiety and quality of life in subjects with atopic eczema in a population‐based cross‐sectional study in Germany

ADHD in school‐age children is related to infant exposure to systemic H1‐antihistamines

Atopic dermatitis and psychosocial comorbidities

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