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“…Another limitation in our study is the absence of information on OTC drug usage in Canada, such as diphenhydramine, since a recent publication has shown evidence for early life exposure to diphenhydramine as independent risk factor for the development of ADHD (12). Another limitation is the reliance on the rather general code 307 in the ICD-9 classification to capture tic disorders.…”
Section: Discussionmentioning
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“…Another limitation in our study is the absence of information on OTC drug usage in Canada, such as diphenhydramine, since a recent publication has shown evidence for early life exposure to diphenhydramine as independent risk factor for the development of ADHD (12). Another limitation is the reliance on the rather general code 307 in the ICD-9 classification to capture tic disorders.…”
Section: Discussionmentioning
“…However, cetirizine is a second-generation antihistamine and minimally penetrates the blood brain barrier compared to its precursor molecule hydroxyzine (11). In contrast, a recent observational study provided evidence that early life exposure to antihistamine drugs, especially the first-generation drug diphenhydramine, may be an independent risk factor for development of attentiondeficit hyperactivity disorder (ADHD) in childhood (12).…”
Section: Introductionmentioning
“…Pedruzzi et al 5 identified 7 microRNAs (miRNAs) that correctly classified DRESS or MPE patients and were associated with keratinocyte differentiation/skin inflammation, type I IFN pathway viral replication, ATP‐binding cassette transporters and T lymphocyte polarization, being all of them potential biomarkers. Non‐immunologically mediated adverse reactions, such as attention‐deficit/hyperactivity disorder (ADHD), are reported by Fuhrmann et al 6 in association with systemic H1‐antihistamines administration in school‐age children, especially the first‐generation agents.…”
Section: Figurementioning
“…Pedruzzi et al 5 identified 7 microRNAs (miRNAs) that correctly classified DRESS or MPE patients and were associated with keratinocyte differentiation/skin inflammation, type I IFN pathway viral replication, ATP-binding cassette transporters, and T lymphocyte polarisation, being all of them potential biomarkers. Non-immunologically mediated adverse reactions, such as attention-deficit/hyperactivity disorder (ADHD) are reported by Fuhrmannet al 6 in association with systemic H1-antihistamines administration in school-age children, especially the 1 st generation agents.…”
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