2010
DOI: 10.1038/ajh.2010.144
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Increased Arterial Stiffness and Impaired Endothelial Function in Nonalcoholic Fatty Liver Disease: A Pilot Study

Abstract: NAFLD is associated with arterial stiffness and endothelial dysfunction. Given the important independent prognostic role of these arterial indexes, these findings have important implications for increased cardiovascular risk in patients with NAFLD.

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Cited by 102 publications
(94 citation statements)
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“…The role of NAFLD in the growth of TIMC is also being studied. It is established that TIMC is greater in patients with NAFLD in comparison with the control group, independently of other traditional RF and the presence of MS [26,28,93,108]. In patients with NAFLD the TIMC value is 1.14 mm on average.…”
Section: Thickness Of Intima-media Complexmentioning
confidence: 91%
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“…The role of NAFLD in the growth of TIMC is also being studied. It is established that TIMC is greater in patients with NAFLD in comparison with the control group, independently of other traditional RF and the presence of MS [26,28,93,108]. In patients with NAFLD the TIMC value is 1.14 mm on average.…”
Section: Thickness Of Intima-media Complexmentioning
confidence: 91%
“…There was no such association among patients with impaired tolerance to carbohydrates and newly diagnosed DM [115]. It was established that patients with histologically confirmed diagnosis of NAFLD, assessed according to the Brunt scale (Brunt of the Global Grade), had significantly higher PVPW rates (8.2 ± 1.3 m/s versus 6.9 ± 1.3 m/s, p = 0.001), greater TIMC (0.79 ± 0.18 m/s vs. 0.67 ± 0.13 m/s, p = 0.01) and lower EDVD (1.93 ± 2.11% versus a 4.8 ± 2.43%, p = 0.001) compared with patients without NAFLD [28]. The data were confirmed by the results of a systematic review of 36 studies, 16 of which had investigated the association between NAFLD and TIMC of carotid arteries, 7 -the relationship between NAFLD and calcification of carotid arteries, 7 with ED, and the rest 6 with AWS [29].…”
Section: Arterial Stiffnessmentioning
confidence: 95%
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“…The correlation between NAFLD severity and IMT is unclear and the three major liver biopsybased studies showed conflicting data. In a Greek study, NAFLD subjects had significantly higher cIMT (0.79 ± 0.18 mm vs 0.67 ± 0.13 mm, P = 0.01), compared to controls and there were no differences observed between NAFLD and NASH [26] . Conversely, Brea et al [27] and Targher et al [28] studies reported a close association between histology of NAFLD and IMT.…”
Section: Imtmentioning
confidence: 99%
“…Vlachopoulos et al [26] found a reduced FMD in patients with NAFLD (1.9% ± 2.1% vs 4.8% ± 2.4% in controls, P < 0.001); in Mohammadi's study FMD was 6.4% in patients and 15.7% in controls (P < 0.001); Thakur et al [30] reported a significantly greater degree of FMD impairment in NAFLD patients than controls (OR = 11.7; 95%CI: 1.4-96.5). Villanova's [31] study described a correlation between NAFLD severity and impaired FMD; in fact, lower FMD value were observed in patients with NAFLD/NASH.…”
Section: Fmdmentioning
confidence: 99%