Increased Anticardiolipin Antibodies Associated With the Development of Anetoderma in Hiv‐1 Disease

Lindstrom, Jill; Smith, Kathleen J.; Skelton, Henry G.; Redfield, Robert; Alving, Barbara M.; Wagner, Kenneth F.; Lupton, George P.

doi:10.1111/j.1365-4362.1995.tb04442.x

Cited by 27 publications

(21 citation statements)

References 39 publications

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“…Many studies have noted the combination of immune dysfunction in patients with HIV infection, which results in autoimmune disease [26]. HIV not only leads to depletion of CD4?…”

Section: Discussionmentioning

confidence: 99%

“…HIV not only leads to depletion of CD4? T cell during the course of disease but induces polyclonal B-cell activation and is associated with marked hypergammaglobulinemia, humoral activation, and autoimmunity [26,27]. This results in a higher frequency of autoimmune disorders including higher titers of antiphospholipid antibodies in HIV-infected patients [28].…”

Section: Discussionmentioning

confidence: 99%

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Serum concentrations of antiphospholipid and anticardiolipin antibodies are higher in HIV-infected women

Abdollahi

Morteza

2011

Rheumatol Int

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Manifestations of viral infections like human immune deficiency virus (HIV) differ between women and men. There are some reports due to a higher risk of thrombosis due to antiphospholipid syndrome in HIV-infected women compared with men. The purpose of this study was demonstrating the impact of gender on serum concentration of antiphospholipid and anticardiolipin antibodies in HIV-infected patients. A total of 58 HIV-infected patients and 58 age, sex-matched healthy adults were enrolled. We measured platelets count, hemoglobin, partial thromboplastin time (PTT); prothrombin time (PT), international normalized ratio (INR), antiphospholipid IgG/IgM and anticardiolipin IgG/IgM serotypes in our studied population. Age, male-to-female ratio, hemoglobin level, PT, INR, antiphospholipid IgM isotype, anticardiolipin IgM and IgG isotypes levels were not significantly different between HIV-infected patients and healthy individuals, when CD4+ T-cell count, CD8+ T-cell count, platelet count, and PTT were significantly lower, and antiphospholipid IgG isotype levels was significantly higher in HIV patients. Antiphospholipid IgG isotypes (3.2 [2.8-4.2] vs. 2.5 [2.3-3.1]; P < 0.001) and anticardiolipin IgG isotypes (2.2 [1.9-2.7] vs. 1.4 [1.4-1.9]; P < 0.001) were significantly higher in HIV-infected women than in HIV-infected men. Antiphospholipid IgG/IgM and anticardiolipin IgG/IgM were significantly correlated in HIV-infected men and women when they did not had any correlation in controls. We suggest that HIV infection accelerate thrombosis in women more profoundly than in men, as a result of differences in disease progression and response to therapy in these patients.

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“…Many studies have noted the combination of immune dysfunction in patients with HIV infection, which results in autoimmune disease [26]. HIV not only leads to depletion of CD4?…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum concentrations of antiphospholipid and anticardiolipin antibodies are higher in HIV-infected women

Abdollahi

Morteza

2011

Rheumatol Int

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“…J-E Herrero-González and CHerrero-Mateu between APL and PA has been described in HIVinfected subjects, 25 who seem to present a signi cant incidence of autoimmune disorders probably caused by an immune dysregulation. 26 Chorea, 27 mitral valve prolapse, 1 ictus, myocardial infarction 1 and glomerulonephritis 1 have also been associated with PA: surprisingly, the same phenomena as those described in patients with increased APL antibodies.…”

Section: Primary Anetodermamentioning

confidence: 97%

Primary anetoderma associated with primary Sjögren's syndrome

Herrero-González

Herrero-Mateu

2002

Lupus

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We report the case of a woman with a primary Sjögren's syndrome who developed asymptomatic anetoderma lesions with no other pathology responsible. This dermatosis has been associated with many autoimmune disorders, in particular lupus erythematosus and lupus-like syndromes. Our literature review found only one previous description of primary anetoderma associated with primary Sjögren's syndrome.

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“…Up to now, the literature contains reports of 35 PA patients demonstrated to have aPL, whether as an isolated laboratory finding (LAC and/or aCL, and/or aβ2GPI), as part of APS, or in conjunction with other clinical and/or laboratory signs of autoimmunity, including SLE. [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. The rapid growth in the number of descriptions of such patients in the literature, from 13 patients until 2000 [26][27][28][29][30][31] to almost double since then, i.e., 22 patients [32][33][34][35][36][37][38][39][40][41], is a reflection of the increased awareness of this association among clinicians.…”

Section: Association With Aplmentioning

confidence: 98%

“…Lindstrom et al [30] found a correlation between increased aCL and the development of anetoderma, mostly secondary, in cases of HIV. Interestingly, lesions of anetoderma, mostly secondary to resolving lesions, have been described in other infectious diseases such as syphilis, leprosy, and Borreliosis [45]; all might be associated with aPL [46].…”

Section: Possible Association Of Secondary Anetoderma and Aplmentioning

confidence: 98%

Primary Anetoderma and Antiphospholipid Antibodies—Review of the Literature

Hodak

David

2007

Clinic Rev Allerg Immunol

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Primary anetoderma (PA) is a rare elastolytic disorder that develops in clinically normal skin or following a nonspecific inflammatory process. The old literature contains numerous reports of the association between PA and lupus eryhtematosus, although the relationship has not been clearly established. In recent years, there has been a growing body of literature linking PA with a wide range of immunologic abnormalities, the most common of which is the presence of antiphospholipid antibodies, with or without antiphospholipid syndrome. The present review summarizes the literature, from the early descriptions pointing toward an immunologic basis of PA and up to the present recognition that PA is a cutaneous sign for autoimmune disorders, in general, and the presence of antiphospholipid in particular.

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Increased Anticardiolipin Antibodies Associated With the Development of Anetoderma in Hiv‐1 Disease

Cited by 27 publications

References 39 publications

Serum concentrations of antiphospholipid and anticardiolipin antibodies are higher in HIV-infected women

Serum concentrations of antiphospholipid and anticardiolipin antibodies are higher in HIV-infected women

Primary anetoderma associated with primary Sjögren's syndrome

Primary Anetoderma and Antiphospholipid Antibodies—Review of the Literature

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