Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson’s disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study

Huang, Peiling; Wang, Songjian; Sun, Ruifeng; Zhu, Ziman; Li, Xiaoling; Li, Wen‐Shan; Wang, Meng-Yue; Meng, Lin; Gong, Wei

doi:10.4103/1673-5374.324863

Cited by 13 publications

(7 citation statements)

References 41 publications

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“…Functional imaging studies related to normal saliva/water swallowing activity and swallowing disorders further confirm abnormalities in the PoCG neural network 39 . The fMRI results confirmed that PD patients with dysphagia showed greater activation in the precentral gyrus and supplementary motor area 37 . Therefore, the enhanced connections from the PoCG.R to the PreCG.L in the PD‐DR group may play a crucial role in salivary swallowing.…”

Section: Discussionsupporting

confidence: 54%

Drooling disrupts the brain functional connectivity network in Parkinson's disease

et al. 2023

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AimsThis study aimed to investigate the causal interaction between significant sensorimotor network (SMN) regions and other brain regions in Parkinson's disease patients with drooling (droolers).MethodsTwenty‐one droolers, 22 PD patients without drooling (non‐droolers), and 22 matched healthy controls underwent 3T‐MRI resting‐state scans. We performed independent component analysis and Granger causality analysis to determine whether significant SMN regions help predict other brain areas. Pearson's correlation was computed between imaging characteristics and clinical characteristics. ROC curves were plotted to assess the diagnostic performance of effective connectivity (EC).ResultsCompared with non‐droolers and healthy controls, droolers showed abnormal EC of the right caudate nucleus (CAU.R) and right postcentral gyrus to extensive brain regions. In droolers, increased EC from the CAU.R to the right middle temporal gyrus was positively correlated with MDS‐UPDRS, MDS‐UPDRS II, NMSS, and HAMD scores; increased EC from the right inferior parietal lobe to CAU.R was positively correlated with MDS‐UPDRS score. ROC curve analysis showed that these abnormal ECs are of great significance in diagnosing drooling in PD.ConclusionThis study identified that PD patients with drooling have abnormal EC in the cortico‐limbic‐striatal‐cerebellar and cortio‐cortical networks, which could be potential biomarkers for drooling in PD.

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Section: Discussionsupporting

confidence: 54%

Drooling disrupts the brain functional connectivity network in Parkinson's disease

et al. 2023

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“…About 35 articles were excluded for the following reasons: absence of coordinates, use of specific stimulation, lack of health group's data, ROI‐based analyses, non‐whole brain scan and duplicate data. Finally, a total of 16 studies were included in the meta‐analysis 6,7,10,12,15,27–37 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Evaluations of sample information were as follows: (1) Age was reported with mean (or median) and standard deviations (or range) The following factors were considered when evaluating imaging methods: (1) The task design was reported (4 points); (2) magnet strength was at least 1.5T (1 point); (3) whole brain coverage scans were performed (1 point); (4) whole brain analysis was automated without a priori regional selection (3 points); (5) the acquisition, processing and analysis techniques were described (2 points); (6) significant results were reported after correction for multiple testing (1 point); (7) coordinates were reported in a standard space (1 point);…”

Section: Literature Quality Assessmentmentioning

confidence: 99%

“…This situation may be related to the fact that there are still many unknowns about the brain mechanism of swallowing. Dysphagia caused by central nervous system impairments was usually associated with abnormalities in brain function 6,7 . Alterations in brain function have also been found in patients with gastroesophageal reflux disease (GERD) 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Dysphagia caused by central nervous system impairments was usually associated with abnormalities in brain function. 6,7 Alterations in brain function have also been found in patients with gastroesophageal reflux disease (GERD). 8 The aim of this study was to recognise the normal brain functional activity during swallowing, thus providing a rationale for evidence-based diagnosis and treatment of dysphagia.…”

Section: Introductionmentioning

confidence: 99%

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Brain functional activity of swallowing: A meta‐analysis of functional magnetic resonance imaging

Huang

Yan

Lin

et al. 2022

J of Oral Rehabilitation

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Background: Swallowing is one of the most important activities in our life and serves the dual roles of nutritional intake and eating enjoyment. Objective:The study aimed to conduct a meta-analysis to investigate the brain activity of swallowing.Methods: Studies of swallowing using functional magnetic resonance imaging were reviewed in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP) and Wan Fang before 30 November 2021. Two authors analysed the studies for eligibility criteria. The final inclusion of studies was decided by consensus. An activation likelihood estimation (ALE) meta-analysis of these studies was performed with GingerALE, including 16 studies.Results: For swallowing, clusters with high activation likelihood were found in the bilateral insula, bilateral pre-central gyrus, bilateral post-central gyrus, left transverse temporal gyrus, right medial front gyrus, bilateral inferior frontal gyrus and bilateral cingulate gyrus. For water swallowing, clusters with high activation likelihood were found in the bilateral inferior frontal gyrus and the left pre-central gyrus. For saliva swallowing, clusters with high activation likelihood were found in the bilateral cingulate gyrus, bilateral pre-central gyrus, left post-central gyrus and left transverse gyrus. Conclusion:This meta-analysis reflects that swallowing is regulated by both sensory and motor cortex, and saliva swallowing activates more brain areas than water swallowing, which would promote our knowledge of swallowing and provide some direction for clinical and other research.

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Functional brain networks associated with the urge for action: Implications for pathological urge

Zouki,

Eapen,

Efron

et al. 2024

Neuroscience & Biobehavioral Reviews

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Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson’s disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study

Cited by 13 publications

References 41 publications

Drooling disrupts the brain functional connectivity network in Parkinson's disease

Drooling disrupts the brain functional connectivity network in Parkinson's disease

Brain functional activity of swallowing: A meta‐analysis of functional magnetic resonance imaging

Functional brain networks associated with the urge for action: Implications for pathological urge

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