Increase of serum interleukin 2 receptor level in thermally injured patients

Teodorczyk-Injeyan, Julita A.; Sparkes, B. G.; Mills, Gordon B.; Falk, R. E.; Peters, Walter

doi:10.1016/0090-1229(89)90020-2

Cited by 41 publications

(12 citation statements)

References 26 publications

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“…Additionally, elevation of sIL-2R levels have been postulated to play a causal role in immunosuppression, a well described phenomenon in malaria ( 17) and certain other disease states (44). High levels of sIL-2R might bind IL-2, reducing the local concentration of IL-2 available and thereby leading to a downregulation of the immune response ( 17,44,62). Such a process may contribute to the suboptimal natural immunity that develops to sporozoites and to blood-stage malaria in endemic regions.…”

Section: Discussionmentioning

confidence: 99%

Serum cytokine profiles in experimental human malaria. Relationship to protection and disease course after challenge.

Harpaz¹,

Edelman²,

Wasserman³

et al. 1992

J. Clin. Invest.

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Serum cytokine profiles were evaluated in immunized and nonimmunized human volunteers after challenge with infectious Plasmodium falciparum sporozoites. Three volunteers had been immunized with x-irradiated sporozoites and were fully protected from infection. Four nonimmune volunteers all developed symptomatic infection at which time they were treated.Sera from all volunteers were collected at 20 time points during the 28-d challenge period; levels of IL-la, IL-1,#, IL-2, IFN-'y, tumor necrosis factor-a, IL-4, IL-6, granulocyte macrophage-colony-stimulating factor, and soluble CD4, CD8, and IL-2 receptor (sCD4, sCD8, and sIL-2R, respectively) were determined by ELISA. C-reactive protein (CRP) was assayed by radial immunodiffusion. Parasitemic subjects developed increases in CRP and IFN-'y, with less marked increases in sIL-2R and sCD8; the other cytokines tested did not change. CRP increases were abrupt and occurred at the onset offever (day 14 after challenge). IFN-'y increases were also abrupt, preceding those of fever and CRP by one day. Increases in sIL-2R and sCD8 were more gradual. Increases in fever, CRP, IFN-'y, and sCD8 were concordant in each volunteer. Early IL-6 increases were noted in the protected vaccinees. Thus, after challenge with virulent P. falciparum, unique systemic cytokine profiles were detectable both in immunized, nonparasitemic volunteers and in unvaccinated, parasitemic subjects. The contrasting cytokine profiles in the two groups may relate to mechanisms of protection and immunopathology in experimental human malaria. (J. Clin. Invest. 1992.90:515-523.)

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Section: Discussionmentioning

confidence: 99%

Serum cytokine profiles in experimental human malaria. Relationship to protection and disease course after challenge.

Harpaz¹,

Edelman²,

Wasserman³

et al. 1992

J. Clin. Invest.

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“…19 A similar release, but at a much lower rate, has also been described in B cells and monocytes, 19 and therefore sIL-2R is usually considered a marker of T-cell activation. Elevated serum sIL-2R concentrations have been reported in burned patients, as part of the inflammatory response and immune dysfunction of the postburn period, 18,20 and in disorders involving the activation of T cells, like autoimmune diseases 21 or organ transplant rejection. 22 In transplant rejection, serum sIL-2R concentrations correlate with the severity of the disease, 22 and, interestingly, they are a sensitive indicator for acute graftvs-host disease in allogeneic bone marrow transplantation, a clinical and biological disorder that, in severe cases, mimics TEN.…”

Section: Commentmentioning

confidence: 99%

Soluble Interleukin 2 Receptor and Interleukin 1α in Toxic Epidermal Necrolysis

Correia¹,

Delgado²,

Roujeau³

et al. 2002

Arch Dermatol

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“…ELISA based on MoAb to two dilTerent epitopes of 55-kD Tae molecules (1L-2R3; supplied by T Cell Sciences. Cambridge, MA), was performed as described previously [5]. …”

Section: Culture Systemmentioning

confidence: 99%

IL-2 regulation of soluble IL-2 receptor levels following thermal injury

Teodorczyk-Injeyan

Sparkes²,

Lalani

et al. 1992

Clinical and Experimental Immunology

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SUMMARYIn theimmunosuppresscd burn patient serum levels of both IL-2 and a soluble form of IL-2 rcecptor alpha (.SIL-2R3;) are signilieantly elevated. Strikingly, the production of these markers hy the in vitro activated patients' cells is decreased. This study examines the role oriL-2 in the decreased production ol" Ihe sIL-2Ra in vitro in patients with major burns (n= 18. 30 to > 70% total body sulace area). Peripheral blood mononuclear cell (PBMC) cultures from patients with highly elevated serum sIL-2R2, and from healthy controls (/f= 12) were activated with concanavalin A (Con A) at initiation. In patients' cultures mitogen-induced increments orslL-2Rz levels were significantly lower. There was a significant negative correlation (r--0-64. /*<0001) between a high serum sIL-2R::( level and a decreased lectin-induced si 1,.-2R2 release mrZ/ro. Low levels orslL-2Rx in patients' samples were not normalized by increasing the nutnber of T lymphocytes. Also exogenous rlL-l was without clTect. whereas rIL-3 increased si L-2Ra release in some cultures. However, si L-2Ra; levels were significantly increased in patients" cultures by (i) addition of exogenous IL-2; (ii) removal of adherent ceUs: (iii) addition of cyclooxygenase inhibitor, indomcthticin: (iv) bypassing cell surface activation by the combination ofthe calcium ionophore A2.1l87and the phorbol ester 12-n-tctradccanoyl acetate. The cyclic AMP-clcvating drug, lorskolin. abrogated the ability of exogenous IL-2 to increase sIL-2Rx production. Thus, in the burn patient, the tcduccd in vitro slL-2R2 release appears to relate to abnormalities in IL-2 production and action mediated through its functional surface receptor. Elevated levels of sIL-2Ro: in vivo may. therefore, reflect systemic activation of T lymphocytes in response to biologically active IL-2,

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Increase of serum interleukin 2 receptor level in thermally injured patients

Cited by 41 publications

References 26 publications

Serum cytokine profiles in experimental human malaria. Relationship to protection and disease course after challenge.

Serum cytokine profiles in experimental human malaria. Relationship to protection and disease course after challenge.

Soluble Interleukin 2 Receptor and Interleukin 1α in Toxic Epidermal Necrolysis

IL-2 regulation of soluble IL-2 receptor levels following thermal injury

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