IL-2 regulation of soluble IL-2 receptor levels following thermal injury

Teodorczyk-Injeyan, Julita A.; Sparkes, B. G.; Lalani, Sheliza; Peters, Walter; Mills, Gordon B.

doi:10.1111/j.1365-2249.1992.tb05828.x

Cited by 16 publications

(4 citation statements)

References 32 publications

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“…Increased serum SIL-2R levels can cause immune escape, reduce interleukin-2 expression, and lead to a massive release of inflammatory factors, leading to systemic organ function syndrome and threatening the life safety of patients. [ 38 ] This study revealed that the serum SIL-2R levels in the SAP group are higher than that in the non-SAP group at admission, while the serum SIL-2R level in the death cases was higher than that in the surviving group patients. Moreover, Spearman correlation analysis shows that serum SIL-2R levels are positively correlated with APACHE II scores ( P < .001), suggesting that serum SIL-2R levels indicate SAP severity.…”

Section: Discussionmentioning

confidence: 85%

Correlation between serum levels of PTX-3, SIL-2R, inflammatory markers, and APACHE II scores in patients with severe acute pancreatitis

Yang

2022

Medicine

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To investigate the correlation of serum pentraxin 3 (PTX-3), soluble interleukin-2 receptor (SIL-2R), C-reactive protein (CRP), procalcitonin (PCT) levels, and acute physiology and chronic health evaluation II (APACHE II) scores in patients with severe acute pancreatitis (SAP). A total of 30 patients with SAP from October 2020 to October 2021 were selected as the SAP group, and 42 patients with mild acute pancreatitis (MAP) or moderate-severe acute pancreatitis (MSAP) was selected as the control group. The serum levels of PTX-3, SIL-2R, CRP, PCT, and APACHE II scores were evaluated. The serum levels of PTX-3, SIL-2R, CRP, PCT, and APACHE II scores at admission in the SAP group were significantly higher than those in the control group (all P < .05). Spearman analysis showed that serum PTX-3, SIL-2R, CRP, and PCT levels were positively correlated with APACHE II scores (all P < .05). The mortality rate within 28 days was 26.7% in the SAP group; moreover, the serum PTX-3, SIL-2R, CRP, and PCT levels and APACHE II scores at admission in the death group were significantly higher than those in the survival group (all P < .05). The receiver operating curve showed that the combined prediction value of all indicators (PTX-3 + SIL-2R + CRP + PCT + APACHE II) was superior to the single indicators, and the diagnostic sensitivity and specificity were 90.9% and 84.2%, respectively. Serum PTX-3, SIL-2R, CRP, and PCT levels and APACHE II scores have high guiding significance in early diagnosis and prognostic evaluation of SAP patients.Abbreviations: AP = acute pancreatitis, APACHE II = acute physiology and chronic health evaluation II, AUC = area under curve, CRP = C-reactive protein, MAP = mild acute pancreatitis, MSAP = moderate-severe acute pancreatitis, PCT = procalcitonin, PTX-3 = serum pentraxin 3, ROC = receiver operating characteristic, SAP = severe acute pancreatitis, SIL-2R = soluble interleukin-2 receptor.

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Section: Discussionmentioning

confidence: 85%

Correlation between serum levels of PTX-3, SIL-2R, inflammatory markers, and APACHE II scores in patients with severe acute pancreatitis

Yang

2022

Medicine

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“…sIL-2R is an immunosuppressive inhibitor of the synthesis and secretion of monocytes and activated T cells. It has a regulatory effect on the function of the interleukin-2 (IL-2)/IL-2R system and competes with IL-2R to bind IL-2, inhibit the IL-2 autocrine, and then reduce the IL-2 immune response (11,12). Related studies have confirmed that the upregulation of sIL-2R expression is accompanied by decreased B cell immune function (13).…”

Section: Discussionmentioning

confidence: 99%

Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis

Zeng¹,

Xi²,

Yang³

et al. 2021

Ann Palliat Med

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Background: To explore the relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and the disease condition and prognosis in patients with severe acute pancreatitis (SAP). Methods: A total of 52 patients with SAP (SAP group) and 50 patients with mild acute pancreatitis (MAP group) admitted to Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China between April 2017 and December 2019 were included in the present study. A further 50 people who had received a healthy physical examination during the same period constituted the healthy control group. The levels of serum GIP, sIL-2R, and sTREM-1 were measured. The levels of serum GIP, sIL-2R, and sTREM-1 were compared among the SAP, MAP and healthy control groups, and the severity of disease (Ranson scoring system) was compared between the SAP and MAP groups. Pearson correlation analysis was used to analyze the correlation between the levels of serum GIP, sIL-2R, and sTREM-1 with the Ranson scores in the SAP group. A receiver operating characteristic (ROC) curve was drawn to evaluate the predictive efficacy of serum GIP, sIL-2R, and sTREM-1 on prognosis.Results: The levels of serum GIP, sIL-2R, and sTREM-1 in the SAP and MAP groups were higher than those in the healthy control group, and the levels in the SAP group were higher than those in the MAP group. The Pearson correlation analysis showed that the levels of serum GIP, sIL-2R, and sTREM-1 in the SAP group were positively correlated with Ranson scores. The levels of serum GIP, sIL-2R, and sTREM-1 in the survival group were lower than those in the deceased group. The ROC curve showed that the best cut-off values of serum GIP, sIL-2R, and sTREM-1 in predicting prognostic survival were 167.040 pg/mL, 70.840 pg/mL, and 128.325 ng/mL, respectively. Conclusions:The levels of serum GIP, sIL-2R, and sTREM-1 are closely related to the severity of illness in patients with SAP and can be used as reference indicators for assessing the onset of SAP and predicting prognosis.Zeng et al. The effect of GIP, sIL-2R and sTREM-1levels in SAP

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“…Растворимые молекулы СD25 продуцируются активированными лимфоцитами. Сывороточный уровень sCD25 служит маркером их активации при различных патологических состояниях, в том числе при механической и ожоговой травме [2][3][4]. Взаимодействуя с интерлейкином 2, растворимые молекулы sCD25 по принципу обратной связи тормозят иммунные реакции, ограничивая чрезмерно развитый иммунный ответ при его гиперактивации.…”

Section: актуальные вопросы патофизиологии обоснованиеunclassified

Soluble Cd25 and Cd95 Molecules Level at Burns

Lebedev¹,

Юрьевич²,

Шолкина³

et al. 2017

Annals RAMS

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Background: Burn injury is accompanied by modulation of the many components of immunity, including the system regulation, which includes soluble forms of leukocyte differentiation molecules. Earlier in burn patients, we detected changes in serum levels of soluble differentiation molecules CD25 (sCD25) and CD95 (sCD25). Despite the existence of data on change of serum level of the soluble molecules CD25 and CD95 in the blood of patients with a burn trauma, there are no data on particular cell producers.Aims: To conduct the analysis of serum level of the molecules sCD25 and sCD95 in the blood of patients with acute burn trauma in comparison with peripheral blood cells composition to obtain data on the types of cells that produce the molecules sCD25 and sCD95.Materials and methods: Blood samples from 24 heavily burnt patients aged 16 to 77 years were studied. Determination of sCD25 and sCD95 molecules serum levels was performed by ELISA. Number of CD45+CD25+ lymphocytes, CD45+CD95+ cells, CD14+CD95+ monocytes, CD16b+CD95+ neutrophils, and RFMI (relative mean fluorescence intensity) was evaluated by flow cytometry.Results: In the first five days of the date of burn sCD25 and sCD95 serum levels tended to increase. sCD25 molecules contents in the blood of surviving and dead patients did not depend on the relative content of CD45+CD25+ lymphocytes, RFMI index, but correlated with the absolute level of lymphocytes and leukocytes. Serum levels of sCD95 molecules showed the dependence on the absolute neutrophil count and leukocytes in the survivors and on the absolute content of lymphocytes, neutrophils, and leukocytes in patients who died.Conclusions: The findings suggest that the lymphocytes in the early period of burn disease are the main cells-producers of sCD25 and affect the increase of its content in the blood serum not due to changes in the density of CD25 molecules expression on their membrane followed by increased shedding but by increasing the number of CD25 positive cells. The main cells-producers of sCD95 molecules for survivors in the early period of burn disease are likely to be the neutrophils and lymphocytes; in the dead patients, the main producers are neutrophils.

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IL-2 regulation of soluble IL-2 receptor levels following thermal injury

Cited by 16 publications

References 32 publications

Correlation between serum levels of PTX-3, SIL-2R, inflammatory markers, and APACHE II scores in patients with severe acute pancreatitis

Correlation between serum levels of PTX-3, SIL-2R, inflammatory markers, and APACHE II scores in patients with severe acute pancreatitis

Relationship between levels of serum gastric inhibitory polypeptide (GIP), soluble interleukin-2 receptor (sIL-2R), and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and disease condition and prognosis of patients with severe acute pancreatitis

Soluble Cd25 and Cd95 Molecules Level at Burns

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