Increase of serum estradiol in cirrhotic men treated by transjugular intrahepatic portosystemic stent shunt

Nolte, W.; Schindler, Christian; Figulla, Hans R.; Wuttke, W.; Hüfner, M.; Hartmann, Heinz; Ramadori, Giuliano

doi:10.1016/s0168-8278(01)00052-6

Cited by 21 publications

(22 citation statements)

References 28 publications

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“…There Table 2 Table 2 Table 2 Table 2 Table 2 , resulting in a significant deterioration in quality of life [3][4][5][6][7][8][9][10] . Our prospective study showed that cirrhotic men have significant alterations in the pituitary regulatory functions, and that these disorders are completely reversed after liver transplantation.…”

Section: Results Results Results Resultsmentioning

confidence: 99%

“…The increase in serum levels of E2 is primarily due to increased peripheral conversion of androgens into estrogens and reduction in liver clearing function 5,7 . Portal hypertension can lead to a diversion of blood flow from the liver to peripheral tissues, resulting in a further increase in the conversion of steroids into estrogens 8 . Although some studies 2,19,20 have established a correlation between increased PRL in cirrhosis and hyperestrogenemia, the mechanism that leads to hyperprolactinemia is not yet clear.…”

Section: Results Results Results Resultsmentioning

confidence: 99%

“…Testicular atrophy, decrease in libido, impotence, oligospermia, infertility, loss of body hair, reduction of prostate size, gynecomastia, vascular spiders, gynecoid distribution of fat and palm erythema are often found in cirrhotic men [5][6][7][8][9][10] . These findings are more pronounced in patients with alcoholic cirrhosis due to the direct harmful effect of ethanol to the testicles.…”

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confidence: 99%

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Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation

Zacharias

Coelho

Parolin

et al. 2014

Rev. Col. Bras. Cir.

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In a prospective study, serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and prolactin (PRL) of 30 male patients with cirrhosis were determined two to four hours before and six months after liver transplantation. The results were compared according to the Model for End-stage Liver Disease (MELD). Results Results ResultsResults Results: male patients with liver cirrhosis have hypogonadism. FSH was normal, but inappropriately low due to androgen failure; E2 and PRL, on their turn, were high. After liver transplantation, FSH and LH levels increased (p < 0.05), whereas E2 and PRL normalized (p < 0.05). The MELD score did not influence changes in FSH, PRL and LH, however, the more severe the cirrhosis was, the more significant was the normalization of E2 (p = 0.01). Conclusion Conclusion Conclusion Conclusion Conclusion: Patients with cirrhosis and male hypogonadism have inappropriately normal levels of FSH and LH, associated with an increase in E2 and LRP. After liver transplantation, FSH and LH increased, while E2 and PRL returned to normal. Changes in E2 levels were most pronounced in patients with MELD > 18. The severity of cirrhosis had no influence on FSH, PRL and LH.

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Section: Results Results Results Resultsmentioning

confidence: 99%

Section: Results Results Results Resultsmentioning

confidence: 99%

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confidence: 99%

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Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation

Zacharias

Coelho

Parolin

et al. 2014

Rev. Col. Bras. Cir.

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“…10,11 Portosystemic shunting appears to play a role in the high incidence of sexual dysfunction. Nolte et al 12 reported that in 17 men who underwent transjugular intrahepatic portosystemic stent shunting, the incidence of erectile dysfunction increased from 30% to 70%. Interestingly, the presence of medications such as beta-blockers does not appear to play a role in sexual dysfunction in this study.…”

Section: Discussionmentioning

confidence: 99%

Sexual functioning in patients with end-stage liver disease before and after transplantation

Sorrell

Brown

2006

Liver Transpl

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The effects of end-stage liver disease (ESLD) on sexual functioning are complex and often overlooked in the context of chronic illness and the transplantation evaluation. The aim of the present study is to report on the prevalence of sexual dysfunction in patients with ESLD presenting for liver transplantation evaluation, as well as to examine a cohort after transplantation. Participants included 173 consecutive adult outpatients with ESLD who presented for orthotopic liver transplantation evaluation. All transplant candidates underwent a psychiatric evaluation, and a sexual history was taken by the transplant psychiatrist. Patients who received a liver transplant were contacted by telephone for follow-up (n ϭ 39). The following domains were explored: sexual frequency, satisfaction, ability to orgasm, sexual interest, and, for men, erectile dysfunction. Before transplantation, high levels of sexual dysfunction were found, with women showing higher levels of dysfunction than men. Increased age and more severe liver disease were related to lower sexual frequency and satisfaction. Contrary to previous work, the cause of disease (alcoholic liver disease) was not related to sexual functioning before transplantation. Those with erectile dysfunction before transplantation showed continued dysfunction after transplantation. An additional finding was an age and gender bias against taking a sexual history from older women. Overall, for both men and women, the findings point to continued and persistent sexual dysfunction after transplantation. Few areas of human behavior are as complex as sexuality. Experiencing oneself as a sexual being and engaging in sexual activity involves a wide range of psychological processes such as emotions, attitudes, and values integrated with optimal physiological functioning. Sexual function, consequently, is uniquely sensitive to illness, psychological distress, and disequilibrium in interpersonal relationships. Chronic illness is associated with sexual dysfunction and results in diminished sexual activity due to malaise, fatigue, and changes in body image. The effects of end-stage liver disease (ESLD) in this arena can be profound and have been attributed to the constitutional effects of illness. For men, hypogonadism and feminization are associated with cirrhosis.1 The impact on women is unclear. In fact, the literature on sexual dysfunction in ESLD essentially ignores women.In addition to the specific effects of liver disease, patients with ESLD have a host of other factors that are likely to adversely influence sexual functioning. With respect to men, vascular disease, diabetes, hypertension, hyperlipidemia, and neuropathy are associated with erectile dysfunction. 2 A host of medications can contribute to erectile dysfunction, although it is difficult to separate the effects of the underlying condition from the drug used to treat it.3,4 Several of these medication classes are commonly prescribed to treat patients with ESLD. They include diuretics, beta-blockers, and antidepressants. Like...

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“…15,16 In a study conducted by Nolte et al reported that in seventeen male patients, those who underwent (transjugular intrahepatic port systemic stent shunting), 30% -70% erectile dysfunction increased. 17 In another study by James H et al also showed partial sexual dysfunction in the 20.6% and complete dysfunction in the 34.3% of the cases.…”

Section: Discussionmentioning

confidence: 90%

Sexual Dysfunction; Patients With Chronic Liver Disease

Bawany

Sahito²,

Naz³

et al. 2017

TPMJ

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ABSTRACT… Objectives:To determine the frequency of sexual dysfunction in the patients suffering from chronic liver disease. Period: 1 year from June 2013 to May 2014. Study Design: An observational study. Setting: Asian Institute of Medical Sciences. Methodology: 150 cases of chronic liver disease including patients of both genders at Asian Institute of medical sciences who had suggestive history and signs /symptoms of sexual dysfunction. Results: Study found 51.3% of total patients were suffering with sexual dysfunction. Out of all participating females, 52.2% were affected and among the total male patients 51% males were suffering from sexual dysfunction. Hepatitis C virus (HCV) and Hepatitis B virus (HBV) were positive in 76.7% and 11.3%, respectively. Conclusion: Sexual dysfunction is a common complication in the patients suffering from chronic liver disease.

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Increase of serum estradiol in cirrhotic men treated by transjugular intrahepatic portosystemic stent shunt

Cited by 21 publications

References 28 publications

Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation

Hypothalamic-pituitary-gonadal function in men with liver cirrhosis before and after liver transplantation

Sexual functioning in patients with end-stage liver disease before and after transplantation

Sexual Dysfunction; Patients With Chronic Liver Disease

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