Increase of retinal nerve fiber layer thickness in ocular hypertensives with timolol therapy

Schwartz, Bernard; Takamoto, Takenori; Lavin, Philip T.; Smits, Gerard

doi:10.1111/j.1600-0420.1995.tb00589.x

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…The course of ocular pressure during this study has been reported previously [5,6]. Both right and left eyes with timolol drops showed a significant decrease of ocular pressures compared to baseline and compared to the placebo for the course of the study (average for periods 1 , 2 and 3 for OD minus baseline, timolol compared to placebo, p <0.001; OS minus baseline, timolol compared to placebo, p < 0.001).…”

Section: B Univariate Analysissupporting

confidence: 73%

“…Details of the subjects selected for this study as well as the methods used were presented elsewhere [5,6] and therefore, a summary of materials and methods will be presented.…”

Section: Methodsmentioning

confidence: 99%

“…The subjects' optic discs had varying amounts of cupping and pallor [ . 5,8] and retinal nerve fiber layer thickness [6].…”

Section: A Subjects and Protocolmentioning

confidence: 99%

“…In previous papers we determined in a double masked randomized clinical trial of timolol and placebo drops in ocular hypertensives, a significant de-crease in measurements of optic disc cupping and pallor [5] and a significant increase in retinal nerve fiber layer thickness which was associated with timolol therapy [6]. However, these changes in the optic disc and retinal nerve fiber layer thickness were not associated with the decrease in ocular pressures with timolol therapy.…”

Section: Introductionmentioning

confidence: 99%

“…The purpose of this study is to report the application of this method to compare the effect of placebo and timolol drops on retinal vessel width in ocular hypertensives in a double masked randomized clinical trial. In these same subjects, we had previously determined decreases in optic disc cupping and pallor and increases in retinal nerve fiber layer thickness [ 5,6].…”

Section: Introductionmentioning

confidence: 99%

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Increase of retinal vessel width in ocular hypertensives with timolol therapy

Schwartz

Takamoto

Lavin

1995

Acta Ophthalmologica Scandinavica

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Abstract. Purpose: The purpose of this study was to determine whether timolol drops compared to placebo drops had a significant effect on retinal vessel width in ocular hypertensives. Methods: Thirty‐seven ocular hypertensives were randomly assigned to receive placebo or 0.5% timolol drops to both eyes for 18 to 24 months in a double masked clinical trial. Measurements of ocular pressure and retinal vessel width by computerized image analysis from fundus photographs were made at about 3 month intervals for 18 to 24 months of follow‐up. Results: None of the subjects developed visual field loss when tested with the Goldmann perimeter by kinetic and static means at six month intervals. Subjects treated with the placebo showed no change in ocular pressure and a significant decrease in retinal vessel width over time especially in the right eye. Subjects treated with timolol had an increase in retinal vessel width compared to the placebo group significant especially for the superior temporal vein. Multivariate analyses indicated that the increase of retinal vessel width was not associated mainly with the ocular pressure on treatment or decrease in ocular pressure on treatment. Conclusion: Timolol treatment was associated with an increase of retinal vessel width. The effect of timolol appears to be related primarily to mechanisms other than the decrease in ocular pressure.

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Section: B Univariate Analysissupporting

confidence: 73%

“…Details of the subjects selected for this study as well as the methods used were presented elsewhere [5,6] and therefore, a summary of materials and methods will be presented.…”

Section: Methodsmentioning

confidence: 99%

“…The subjects' optic discs had varying amounts of cupping and pallor [ . 5,8] and retinal nerve fiber layer thickness [6].…”

Section: A Subjects and Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increase of retinal vessel width in ocular hypertensives with timolol therapy

Schwartz

Takamoto

Lavin

1995

Acta Ophthalmologica Scandinavica

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Using the Arteriolar Pressure Attenuation Index to Predict Ocular Hypertension Progression to Open-angle Glaucoma

Cohen

Lee²,

Herndon³

et al. 2003

Arch Ophthalmol

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Background: Vascular phenomena are considered important to optic nerve and visual field progression in open-angle glaucoma(OAG).Arecentlydescribedformulation,thePressure Attenuation Index (PAI), links arteriolar caliber variations to pressure loss along the retinal arteriolar system. Objective: To examine whether the PAI could predict ocular hypertension (OHT) progression to OAG. Methods: The PAI was calculated for 27 eyes of 14 patients with OHT using initial and final digitized optic disc photographs taken during a follow-up interval of 5 to 18 years. Serial stereo color disc photographs and visual fields were analyzed to determine progression. Results: At baseline, the arteriolar tree of 8 subjects with OHT that progressed to OAG (n=8 eyes) demonstrated a 45.8% greater mean PAI value than that of 7 subjects who did not progress (n=7 eyes) (mean±SEM, 5.31±0.93 vs 3.64±0.34; r=0.83). Progression was independent of baseline cup-disc ratio. The PAI values of subjects with stable OHT remained stable after a median follow-up interval of 12.0 years. The PAI values of subjects with OHT that progressed demonstrated a further increase of 19.97%±11.24% during a median follow-up period of 6.0 years. Conclusions: The results support the hypothesis that low end-arteriolar pressure predicts the progression from OHT to OAG. The PAI provides a new, early, reproducible, and physiological method to study vascular phenomena in glaucoma.

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Medical interventions for primary open angle glaucoma and ocular hypertension

Vass

Hirn

Sycha

et al. 2007

Cochrane Database of Systematic Reviews

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Analysis 2.1. Comparison 2 Comparison of timolol and carteolol, Outcome 1 Incidence of visual field defect progression.......... Analysis 3.1. Comparison 3 Comparison of timolol and levobunolol, Outcome 1 Incidence of visual field defect progression....... Analysis 3.2. Comparison 3 Comparison of timolol and levobunolol, Outcome 2 Drop-out due to drug-related adverse events..... Analysis 4.1. Comparison 4 Comparisons of timolol and betaxolol, Outcome 1 Change of visual field mean sensitivity............... Analysis 4.2. Comparison 4 Comparisons of timolol and betaxolol, Outcome 2 Drop-out due to drug-related adverse events...... Analysis 5.1. Comparison 5 Comparison of timolol and brimonidine, Outcome 1 Incidence of visual field defect progression...... Analysis 5.2. Comparison 5 Comparison of timolol and brimonidine, Outcome 2 Drop-out due to drug-related adverse events..... Analysis 6.1. Comparison 6 All treatments versus placebo or untreated, Outcome 1 Incidence of visual field defect progression.... Analysis 6.2. Comparison 6 All treatments versus placebo or untreated, Outcome 2 Sensitivity analysis concerning the incidence of visual field progression.

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Increase of retinal nerve fiber layer thickness in ocular hypertensives with timolol therapy

Cited by 8 publications

References 13 publications

Increase of retinal vessel width in ocular hypertensives with timolol therapy

Increase of retinal vessel width in ocular hypertensives with timolol therapy

Using the Arteriolar Pressure Attenuation Index to Predict Ocular Hypertension Progression to Open-angle Glaucoma

Medical interventions for primary open angle glaucoma and ocular hypertension

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