Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma

Iamaroon, Anak; Pongsiriwet, Surawut; Jittidecharaks, Sumana; Pattanaporn, Komkham; Prapayasatok, Sangsom; Wanachantararak, Sitthichai

doi:10.1034/j.1600-0714.2003.00128.x

Cited by 141 publications

(128 citation statements)

References 24 publications

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“…21,22 Tumours can grow to a size that exceeds its blood supply, leading to tumour necrosis and ulceration. 23 In the present study the patients most frequently presented with an ulcerating lesion. This result is comparable to another study recently conducted in Pakistan wherein the most common clinical presentation of OSCC was as nonhealing indurated ulcer (51.4%) which was significantly common on the buccal mucosa (p=0.001).…”

Section: Discussionmentioning

confidence: 82%

Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

Gul

Asif

Ghaffar

et al. 2017

Int J Community Med Public Health

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Background: Cancer archives perform a dynamic role in observing the prevalence of these cancers. The present study was carried out to study the epidemiological and pathological trends of oral squamous cell carcinoma (OSCC) in a local tertiary care hospital. Methods: Tissue samples were taken from the adult patients of both genders undergoing surgery for OSCC after an informed consent following the inclusion and exclusion criteria. Socio-demographic information was obtained along with relevant clinical, laboratory findings. Tissue samples were stained with H & E stains and were graded according to Anneroth’s system of histological grading. Data were analysed using SPSS 20.0 and a p value ≤0.05 was taken as significant. Results: The most common site for OSCC was tongue and the most common histological subtype was conventional squamous cell carcinoma, while well differentiated tumours form the largest number in the current study. Conclusions: OSCC is a growing malignancy in Pakistan with significant morbidity and mortality and the findings of the present study will be a valuable addition in the local cancer archives.

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Section: Discussionmentioning

confidence: 82%

Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

Gul

Asif

Ghaffar

et al. 2017

Int J Community Med Public Health

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“…8 -11 Mast cells produce a broad repertoire of cytokines to regulate inflammatory responses, growth factors to stimulate blood vessels and fibroblasts, and enzymes capable of releasing growth factors from extracellular matrix. 5,8 -11,27,28,42 In other human tumors studies it has been shown that mast cell function is complicated with both pro -and antitumor effects, 35,[43][44][45][46] but to the best of our knowledge no studies have previously described differential roles of mast cells depending on the local microenvironment within the same clinical material. It is well established that inflammatory cell types within or surrounding tumors such as tumor-associated macrophages 47 and more lately also neutrophils 48 can be educated by growth factors and cytokines within the tumor microenvironment to acquire pro-or antitumor properties.…”

Section: Discussionmentioning

confidence: 94%

“…[5][6]33,[35][36] FGF-2 has previously been identified as a growth factor released by mast cells by degranulation. 36 FGF-2 is known to be produced in the prostate stroma and acts together with its receptor FGF-R1 as stimulators of epithelial as well as vascular growth and are of major importance in PC in both animal models and patients.…”

Section: Discussionmentioning

confidence: 99%

Mast Cells Are Novel Independent Prognostic Markers in Prostate Cancer and Represent a Target for Therapy

Johansson

Rudolfsson

Hammarsten

et al. 2010

The American Journal of Pathology

189

187

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Mast cells affect growth in various humanCancer growth is dependent on the reciprocal interaction between tumor cells and their microenvironment. Cancerassociated fibroblasts, 1 vascular cells, and inflammatory cells such as macrophages [2][3][4] have been shown to promote prostate tumor growth. Mast cells are also of importance for tumor growth and have been shown to affect angiogenesis 5-7 but are also potent regulators of inflammation and thus their specific function during tumor progression is complex and shows significant plasticity. 8 -10 Their role in prostate cancer (PC) in patients was recently explored in two separate studies using tryptase and c-Kit as markers for mast cells. These studies lacked the discrepancy between intra-and peritumoral mast cells and did not identify mast cells as independent prognostic variables. One of the studies showed that tryptase-positive mast cells were related to poor outcome in PC patients. 12 The other study analyzed c-Kit-positive cells in tumor samples from PC patients and found an association between increased mast cell numbers and a favorable prognosis. 13Castration therapy is the gold standard for treatment of patients with metastatic PC, but in the majority of cases the formation of castrate-resistant prostate tumors is inevitable. The mechanisms behind the relapse are not fully understood but could be related to changes in the androgen receptor and the tumor stroma.

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“…The density of the mast cells in a tissue was studied by using histochemical stains like toluidine blue and [5] alcian blue [2] and immunohistochemically [20] by using mast cell tryptase, heparin, chymase, and carboxypeptidase A. The present study employed the quantification of the mast cells in the area of the 'hot spots'.…”

Section: Discussionmentioning

confidence: 99%

The Relevance of Mast Cells in Oral Squamous Cell Carcinoma

Cheema¹,

Ramesh²,

Balamurali³

2012

JCDR

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Context:The commonly occurring oral neoplasm -Oral Squamous Cell Carcinoma (OSCC) has an association with the chronic inflammation in the adjacent connective tissue. Mast cells are the local residents of the connective tissue. They are said to be pro inflammatory and immune-amplifying in action and they produce mitogenic cytokines. They exhibit a phenotypic plasticity with a change in the microenvironment, thus making the role of the mast cells in this disease even more intriguing. Mast cells have also been reported to play a role in tumour progression and metastases by promoting angiogenesis.Aims: The present study aimed at comparing the Mast Cell Density (MCD) in the Normal Oral Mucosa (NM) and among the various grades of OSCC and at analyzing the possible role of the mast cells. Settings and Design:The MCD was assessed by using the 1% Toluidine blue stain in a study sample of 102 cases of different grades of OSCC and in 07 cases of clinically normal oral mucosa.Statistical Analysis Used: By using the Student's 't' test and one way ANOVA, the Mast Cell Density (MSD) was found to be significantly higher in well differentiated squamous cell carcinoma and in moderately differentiated squamous cell carcinoma as compared to that in the poorly differentiated oral squamous cell carcinoma (P=< 0.01) which was significant at a 1% level. The Spearman's Rank Correlation Co-efficient revealed a significant correlation between the density of the mast cells and the increasing grade of the OSCC. Conclusions:These findings denote that as the squamous cell carcinoma enters the poorly differentiated state, there may be some change which is reflected as a decrease in the mast cell density.

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Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma

Abstract: These findings suggest that MCs may upregulate tumor angiogenesis in oral SCC, perhaps via MC tryptase.

Cited by 141 publications

References 24 publications

Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

Mast Cells Are Novel Independent Prognostic Markers in Prostate Cancer and Represent a Target for Therapy

The Relevance of Mast Cells in Oral Squamous Cell Carcinoma

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