Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

Abstract

Background: Cancer archives perform a dynamic role in observing the prevalence of these cancers. The present study was carried out to study the epidemiological and pathological trends of oral squamous cell carcinoma (OSCC) in a local tertiary care hospital. Methods: Tissue samples were taken from the adult patients of both genders undergoing surgery for OSCC after an informed consent following the inclusion and exclusion criteria. Socio-demographic information was obtained along with relevant clinical, laboratory findings. Tissue samples were stained with H & E stains and were graded according to Anneroth’s system of histological grading. Data were analysed using SPSS 20.0 and a p value ≤0.05 was taken as significant. Results: The most common site for OSCC was tongue and the most common histological subtype was conventional squamous cell carcinoma, while well differentiated tumours form the largest number in the current study. Conclusions: OSCC is a growing malignancy in Pakistan with significant morbidity and mortality and the findings of the present study will be a valuable addition in the local cancer archives.

Immunoexpression of Matrix Metalloproteinase-9 in Histopathological tissue samples of oral Squamous Cell Carcinoma

“…The most common histopathologically variant of OSCC reported by our study was WDSCC (40%) followed by MDSCC (28%) and PDSCC (12%). Our study showed results (Table 4) which are in accordance with other studies reported, such as WDSCC (35%) by Siriwardena et al and Gul et al (42.5%) of WDSCC 18,22 . These findings were different from some previous studies reported by Remin et al who showed increased cases among moderately (42%) and poorly differentiated squamous cell carcinomas (15%) 24 .…”

“…The present study observed a mean age of 56.52 for OSCC cases and a male-female ratio of 1.6:1 was observed. This finding is supported by studies reported by Mirza et al, and Gul et al, who observed a male-female ratio of 1.6:1 6,18 . While this finding is contrary to Beena et al, who observed that most cases were reported in the younger age group (77%) 19 .…”

Perfil del Carcinoma Oral de Células Escamosas en el Laboratorio de Anatomía Patológica de la Facultad de Odontología de la Universidad de la República, período 1982-2015

“…Al analizar el grado de diferenciación histopatológico encontramos resultados similares a los obtenidos en nuestro estudio, Wei-ping Jie y col. reportan el 90,8% de los casos fueron los COCE bien diferenciados y moderadamen-te diferenciados (38) . Otros estudios mostraron datos similares, Sairay col. en Pakistán para el período 2015-2016 mostró que el 52% de los COCE fueron moderadamente diferenciados y el 42% bien diferenciados (39) , mientras Gul y col. obtuvieron en un Hospital terciario del sur de Punjab India, un 43% de pacientes con COCE bien diferenciado, 38% moderadamente diferenciado y 20% con COCE indiferenciado (40) . Leite y col. en 2018 en un estudio de Brasil de COCE en una población de bajo desarrollo económico, n=194 casos, el 54,6% fueron bien diferenciados, 37,1% moderadamente diferenciados y 5,2% carcinomas indiferenciados, este estudio reporta un perfil similar a nuestro estudio (41) .…”

Demographic trends, affected anatomical sites and clinicopathological analysis for oral squamous cell carcinoma at a tertiary care hospital in Tuticorin, Tamilnadu

“…[5] Currently, with therapeutic breakthroughs, cancer now fits into a new category of manageable chronic diseases, which is largely achieved through modification in lifestyle, timely diagnosis and proper management. [6] But regardless of being in anatomic sites easily accessible for clinical examination and inspite of recent diagnostic and therapeutic advances, OSCC's still remains to be a condition with poor prognosis, as the disease is often diagnosed at an advanced stage. Most frequent reasons are the early wrong diagnosis and the ignorance from the patient and/or attending physician or dentist.…”