Increase in the number and volume of myenteric neurons in the adult rat

Robecchi, Maria G. Giacobini; Cannas, M.; Filogamo, G

doi:10.1016/0736-5748(85)90058-9

Cited by 17 publications

(3 citation statements)

References 15 publications

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“…Rearing of rats in darkness resulted in inhibition of cell division in the visual system centers (MareS et al, 1977). DNA synthesis is reported in activated neurons in vocalization centers of canaries before the singing period (Goldman and Nottebohm, 1983) and for neurons of the myenteric plexus during experimental hypertrophy in rats (Giacobini-Robecchi et al, 1985). A functional significance of cell division would agree with the lower incidence of LCs observed in frogs during hibernation, since it is accompanied by a decrease in electrical activity of neurons in many brain regions (Heller, 1979).…”

Section: Functional and Comparative Commentsmentioning

confidence: 76%

Premitotic DNA synthesis in the brain of the adult frog (Rana esculenta L.): An autoradiographic 3H‐thymidine study

et al. 1990

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Replicative synthesis of DNA in the brain of the adult frog was studied by light microscope autoradiography. Animals collected during the active period (May-June) and in hibernation (January) were used. In active frogs, 3H-thymidine labelling occurred mainly in the ependymal cells which line the ventricles. The mean labelling index (LI%) was higher in the ependyma of the lateral and fourth ventricles than in the ependyma of the lateral diencephalon and tectal parts of the mesencephalon. In the recessus infundibularis and preopticus the number of labelled cells (LCs) was several times greater than in the lateral parts of the third ventricle. LCs were seen subependymally only occasionally. The incidence of LCs in the parenchyma of the brain was much lower in most regions than in the ventricular ependyma; LCs were mainly small and, from their nuclear morphology, they were glial cells. The LI% reached the highest value in the septum hippocampi and in the nucleus entopeduncularis. In these locations, LCs were larger and closer in size to the nerve cells of these regions. From comparison with data obtained earlier in the brain of mammals, it is evident that the distribution of proliferating cells in the olfactory and limbic system is phylogenetically conservative. The occurrence of pyknotic cells in the same areas which contain LCs, suggests that cell division reflects in part the process of cell renewal observed in mammals. However, proliferating cells could also be linked to the continuous growth observed in non-mammalian vertebrates. In hibernating frogs, LCs and pyknoses were not seen or were found occasionally, which further indicates the functional significance of both processes.

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Section: Functional and Comparative Commentsmentioning

confidence: 76%

Premitotic DNA synthesis in the brain of the adult frog (Rana esculenta L.): An autoradiographic 3H‐thymidine study

et al. 1990

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“…not followed by cell division) occurs in some myenteric neurons from the hypertrophic loops. In fact, while autoradiography after 3 H-thymidine administration and PCNA immuno-staining showed the presence DNA neosynthesis in myenteric neurons (Giacobini-Robecchi et al, 1985, 1988Poncino et al, 1991;Corvetti et al, 2001) cytophotometry after Feulgen staining suggested that this neosynthesis not associated with cell division but with a hyperdiploid DNA content (Giacobini-Robecchi et al, 1988;Poncino et al, 1991). In addition, electrophoretic analysis of the total genomic DNA extracted from myenteric ganglia isolated from hypertrophic loops have shown the presence of extra-bands migrating below the high molecular weight DNA, suggesting that DNA amplification can be the mechanism of the observed unscheduled DNA synthesis (Giacobini-Robecchi et al, 1995).…”

Section: Postnatal Histogenesis In the Autonomic Nervous Systemmentioning

confidence: 93%

Postnatal histogenesis in the peripheral nervous system

Geuna

Borrione

Filogamo

2002

Intl J of Devlp Neuroscience

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The issue of postnatal neurogenesis has gained great importance over the last few years and the recent amazing scientific advancements, changing our viewpoint on the long-lasting "no new neurons" dogma, have opened promising new perspectives on the treatment of the damaged nervous system. While most of the researchers have focused on the central nervous system, the peripheral nervous system has received little attention so far with respect to postnatal histogenesis. To attract scientific attention on this issue, the present article was written with the aim of reviewing the body of literature on postnatal histogenesis in the various districts of the peripheral nervous system, from the historical roots to the most recent reports.

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“…In 1951, Benninghoff showed that ligation of the rat small intestine induced, in the tract upstream from the stenosis, an increase in the number of autonomic nerve cells of the Auerbach's plexus. The same experimental model was also addressed in depth by Filogamo and coworkers (Filogamo and Vigliani, 1954;Giacobini-Robecchi et al, 1985) who confirmed the marked increase (up to fourfold) in number of Auerbach's plexus ganglion neurons of the loops immediately upstream from the obstruction. Since there was no evidence of cell proliferation by nerve cells, the observed increase in the number of neurons was attributed to the persistence in the adult Auerbach's plexus of poorly differentiated or undifferentiated cells capable of turning into neurons under the influence of excep- tional stimuli.…”

Section: Peripheral Nervous System (Pns)mentioning

confidence: 76%

Adult stem cells and neurogenesis: Historical roots and state of the art

Geuna

Borrione²,

Fornaro³

et al. 2001

Anat. Rec.

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Over the last few years, an impressive number of papers have addressed the stem cell issue. However, as often occurs when a scientific subject undergoes a period of fast growth, some confusion is generated. To help reduce the existing uncertainty, this paper focuses on the concept of adult stem cells in relation to the classification of cell populations on the basis their proliferative behavior. Particular attention is dedicated to adult neural stem cells, an issue that has recently seen the most amazing advances. Finally, the concept of adult stem cells is differentiated from that of developmental stem cells in relation to the employment of stem cells for transplantation therapies. Anat Rec (New Anat) 265:132-141, 2001.

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Increase in the number and volume of myenteric neurons in the adult rat

Abstract: In response to enhanced functional activity, only the larger neurons of the myenteric plexus incorporate thymidine. Their number, too, is increased. This phenomenon is not accompanied by proliferation.

Cited by 17 publications

References 15 publications

Premitotic DNA synthesis in the brain of the adult frog (Rana esculenta L.): An autoradiographic 3H‐thymidine study

Premitotic DNA synthesis in the brain of the adult frog (Rana esculenta L.): An autoradiographic 3H‐thymidine study

Postnatal histogenesis in the peripheral nervous system

Adult stem cells and neurogenesis: Historical roots and state of the art

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