Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide

McEntegart, Margaret; Awede, Bonaventure; Petrie, Mark C.; Sattar, Naveed; Dunn, Francis G.; MacFarlane, Niall G.; McMurray, John J.V.

doi:10.1093/eurheartj/ehm033

Cited by 144 publications

(141 citation statements)

References 37 publications

(60 reference statements)

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“…The use of siRNA against C/EBPa in 3T3-L1 cells clearly induces a reduction of adiponectin expression (Vernochet et al 2010). Interestingly, patients with heart failure, who develop cachexia, also present higher levels of adiponectin (McEntegart et al 2007), and in cancer cachexia patients, this parameter is robustly correlated with body weight loss ( Batista Jret al 2012). On the other hand, leptin secretion, which has been shown to be positively correlated with fat cell size, decreased by 50% 14 days after tumour cell inoculation.…”

Section: Discussionmentioning

confidence: 99%

Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia

Batista¹,

Neves²,

Peres³

et al. 2012

Journal of Endocrinology

100

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Cancer cachexia induces loss of fat mass that accounts for a large part of the dramatic weight loss observed both in humans and in animal models; however, the literature does not provide consistent information regarding the set point of weight loss and how the different visceral adipose tissue depots contribute to this symptom. To evaluate that, 8-week-old male Wistar rats were subcutaneously inoculated with 1 ml (2!10 7 ) of tumour cells (Walker 256). Samples of different visceral white adipose tissue (WAT) depots were collected at days 0, 4, 7 and 14 and stored at K80 8C (seven to ten animals/each day per group). Mesenteric and retroperitoneal depot mass was decreased to the greatest extent on day 14 compared with day 0. Gene and protein expression of PPARg2 (PPARG) fell significantly following tumour implantation in all three adipose tissue depots while C/EBPa (CEBPA) and SREBP-1c (SREBF1) expression decreased over time only in epididymal and retroperitoneal depots. Decreased adipogenic gene expression and morphological disruption of visceral WAT are further supported by the dramatic reduction in mRNA and protein levels of perilipin. Classical markers of inflammation and macrophage infiltration (f4/80, CD68 and MIF-1a) in WAT were significantly increased in the later stage of cachexia (although showing a incremental pattern along the course of cachexia) and presented a depot-specific regulation. These results indicate that impairment in the lipid-storing function of adipose tissue occurs at different times and that the mesenteric adipose tissue is more resistant to the 'fat-reducing effect' than the other visceral depots during cancer cachexia progression.

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Section: Discussionmentioning

confidence: 99%

Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia

Batista¹,

Neves²,

Peres³

et al. 2012

Journal of Endocrinology

100

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“…High plasma levels of adiponectin observed in pts with established CHF were associated with poor prognosis and mortality. Reduced renal clearance could account for higher adiponectin concentration in CHF pts [34]. In haemodialysis pts low plasma adiponectin levels were associated with pre-existing CVD and predicted mortality outcomes [35].…”

Section: Discussionmentioning

confidence: 99%

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

2009

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International audienceAdipose tissue is regarded as an active metabolic and endocrine organ producing adipokines. The purpose of the study was to evaluate adiponectin and leptin concentrations in rheumatoid arthritis (RA) patients (pts) in relation to disease duration and activity. The study group consisted of 80 RA pts. Serum adiponectin and leptin concentrations remained within normal ranges. Adiponectin concentration correlated positively both with the age and disease duration. Both adipokines levels correlated negatively with glomerular filtration rate. There were significant positive correlations between adipokines' concentrations and lipid profile components (between adiponectin and HDL-cholesterol, leptin and total cholesterol and LDL-cholesterol). In pts with long-standing RA, there was a negative correlation between adiponectin and numbers of tender, swollen joints and a positive relationship between leptin level and DAS28. The results confirm adipokines' involvement in the process of inflammation and atherosclerosis: protective and antiinflammatory adiponectin effect and proatherogenic and proinflammatory leptin function

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“…High levels of adiponectin may simply reflect the hyper-catabolic state in severe heart failure. 40 McEntegart et al 43 have recently shown that adiponectin levels are increased in patients with heart failure in the presence of cachexia. Therefore, it is necessary to clarify whether increased levels of adiponectin may be involved in the pathogenesis of heart failure or if they simply reflect the degree of cachexia in these patients.…”

Section: Obesity and Adiponectinmentioning

confidence: 99%

“…Therefore, it is necessary to clarify whether increased levels of adiponectin may be involved in the pathogenesis of heart failure or if they simply reflect the degree of cachexia in these patients. 43 Recombinant adiponectin may have a beneficial role in the therapeutic treatment and prevention of cardiovascular diseases in the future. 9,29,39 conclusion Adiponectin is a key adipokine, which participates in many metabolic activities and its levels are reduced in obese people.…”

Section: Obesity and Adiponectinmentioning

confidence: 99%

Relationship between adiponectin, obesity and insulin resistance

Balsan¹,

Vieira²,

Oliveira³

et al. 2015

Rev. Assoc. Med. Bras.

137

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Conflict of interest: noneObjectives: the conditions of obesity and overweight pose a major risk for a number of comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent studies strongly indicate that adipose tissue is an active endocrine organ that secretes bioactive factors such as adipokines. Adiponectin appears to have a regulatory role in the mechanism of insulin resistance and in the development of atherosclerosis. This systematic review aims to evaluate the anti-atherogenic effects of adiponectin and its properties to improve and mimic metabolic and vascular actions of insulin and its influence on endothelial function. Methods: a qualitative, exploratory and literature review was performed in the PubMed, Portal Capes and Scielo databases using as key-words "adiponectin", "obesity", "insulin resistance", "anti-inflammatory", "therapeutic strategies" and "future prospects". Results: evidence suggests that adiponectin has anti-atherogenic properties with anti-inflammatory effects on the vascular wall. Moreover, it modifies the vascular intracellular signaling and has indirect antioxidant effects on the human myocardium. On the other hand, there are studies suggesting that increased levels of adiponectin are paradoxically associated with a worse prognosis in heart failure syndrome, although the mechanisms are not clear. Conclusion: it is not clear whether adiponectin levels have any clinical significance for risk stratification in cardiovascular disease or if they simply reflect the activation of complex underlying mechanisms. Changes in lifestyle and some drug treatments for hypertension and coronary heart disease have shown significant effect to increase adiponectin levels, and simultaneously decrease in insulin resistance and endothelial dysfunction.

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Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide

Cited by 144 publications

References 37 publications

Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia

Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia

Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Relationship between adiponectin, obesity and insulin resistance

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