Increase in serum 25-hydroxyvitamin-D3 in humans after sunbed exposures compared to previtamin D3 synthesis in vitro

Orlova, Tetiana; Moan, Johan Emelian; Lagunova, Zoya; Aksnes, Lage; Terenetskaya, I. P.; Juzeniene, Asta

doi:10.1016/j.jphotobiol.2013.03.006

Cited by 14 publications

(15 citation statements)

References 22 publications

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“…It is true that sunbed use can increase the serum levels of 25‐OH‐D and several studies have confirmed this finding . On the other hand, this increase is in most cases only transient and not sustained if sunbed use is not regular and continuous: a plateau in 25‐OH‐D level is indeed reached after just a few sunbed sessions due to a balance between photo‐production and photo‐degradation .…”

Section: Uvb Emission By Sunbeds Raises Vitamin D Levelsmentioning

confidence: 94%

“…19 Before ceasing operation and dissolving the organization in August 2017 under the pressure of the Melanoma Research Foundation, 22 the Indoor Tanning Association had worked for decades to promote the sunbed industry despite the large evidence of the hazards of indoor tanning, in particular providing the public with misleading messages such as that sunlight is the 'only' way for the body to manufacture the necessary vitamin D. 23 It is true that sunbed use can increase the serum levels of 25-OH-D and several studies have confirmed this finding. 2,[24][25][26][27][28][29][30][31][32][33][34] On the other hand, this increase is in most cases only transient and not sustained if sunbed use is not regular and continuous: a plateau in 25-OH-D level is indeed reached after just a few sunbed sessions due to a balance between photo-production and photo-degradation. 24,25 Porojnicu et al 28 observed an increase in vitamin D levels after sunbed exposure but showed that within 8 weeks after the last exposure serum 25-OH-D levels decreased to the initial value.…”

Section: Uvb Emission By Sunbeds Raises Vitamin D Levelsmentioning

confidence: 99%

“…UVB light (wavelengths 290–315 nm) is the main inducer of vitamin D by photoisomerization of the 7‐dehydrocholesterol in the epidermal keratinocytes into previtamin D 3 , which is then rapidly converted into vitamin D 3 (cholecalciferol) in the stratum basale and stratum spinosum of the epidermis . This photosynthesis takes place at sub‐erythemogenic UV doses, while longer UV exposures photo‐degrades vitamin D, which explains why excessive sun exposure does not result in vitamin D toxicity . Indeed, vitamin D toxicity may be caused only by excessive doses of vitamin D supplements not by diet or sun exposure, as the body is able regulate vitamin D levels in a physiological scenario .…”

Section: Introductionmentioning

confidence: 99%

“…1 This photosynthesis takes place at sub-erythemogenic UV doses, while longer UV exposures photo-degrades vitamin D, which explains why excessive sun exposure does not result in vitamin D toxicity. 2 Indeed, vitamin D toxicity may be caused only by excessive doses of vitamin D supplements not by diet or sun exposure, as the body is able regulate vitamin D levels in a physiological scenario. 3 A minor source of vitamin D is dietary intake.…”

Section: Introductionmentioning

confidence: 99%

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Overview on vitamin D and sunbed use

Pierret

Suppa

Gandini

et al. 2019

Acad Dermatol Venereol

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Vitamin D seems to be associated with a protective effect in a vast range of diseases, including cardiovascular, autoimmune and oncologic conditions. Since ultraviolet (UV) B light is the most important prerequisite for the cutaneous synthesis of vitamin D, sunbeds are able to increase serum vitamin D levels, although only transiently in most cases. In this scenario, the artificial tanning industry relentlessly tries to promote the use of sunbeds as a ‘safe’ therapeutic measure to achieve an adequate serum vitamin D status. The World Health Organization classified UV‐emitting tanning devices, as well as the whole UV spectrum, as group‐1 carcinogens, as they significantly increase the risk of melanoma and non‐melanoma skin cancer. In case of vitamin D deficiency or insufficiency, the current risk‐benefit ratio is therefore in favour of vitamin D supplementation instead of sunbed use. Artificial tanning devices should never be considered as an option to achieve an appropriate vitamin D status. Their supposedly beneficial effects, vastly publicised by the artificial tanning industry, are not worth the carcinogenic risk associated with sunbed use.

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Section: Uvb Emission By Sunbeds Raises Vitamin D Levelsmentioning

confidence: 94%

Section: Uvb Emission By Sunbeds Raises Vitamin D Levelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Overview on vitamin D and sunbed use

Pierret

Suppa

Gandini

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Direct measurements of the vitamin D level in blood of healthy volunteers exposed to artificial UV source (sunbed) in parallel with measurements of vitamin D generation in vitro were performed to provide a missing link between in vivo and in vitro measurements [23].…”

Section: Testing Of a Sunbedmentioning

confidence: 99%

Metrology of the vitamin-D-synthetic activity of UV lamps

Terenetskaya

Orlova

2017

18th International Congress of Metrology

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Abstract. Ultraviolet lamps are widely used in phototherapy, and positive health effect of UV irradiation is associated with the synthesis of vitamin D in human skin. Nevertheless, to avoid harmful effects of UV radiation a variety of commonly used broadband UV detectors have an output in erythema units. Therefore the measurement of the vitamin-D-synthetic capacity is a missing link in the metrology of UV lamps that are used for medical and/or cosmetic purposes. This paper presents original UV measuring device based on the same photoreaction in vitro by which vitamin D is synthesized in human skin via photo-and thermo-induced conversions of 7-Dehydrocholesterol (provitamin D 3 ). Thus the targets for UV photons are provitamin D molecules embedded in specially designed UV transparent and stable matrix mimicking biological samples. Three operation modes of varying complexity are developed to follow the photoreaction course in real time.

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Physical Determinants of Vitamin D Photosynthesis: A Review

2021

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Vitamin D synthesis by exposure of skin to solar ultraviolet radiation (UVR) provides the majority of this hormone that is essential for bone development and maintenance but may be important for many other health outcomes. This process, which is the only wellestablished benefit of solar UVR exposure, depends on many factors including genetics, age, health, and behavior. However, the most important factor is the quantity and quality of UVR reaching the skin. Vitamin D synthesis specifically requires ultraviolet B (UVB) radiation that is the minority component (<5%) of solar UVR. This waveband is also the most important for the adverse effects of solar exposure. The most obvious of which is sunburn (erythema), but UVB is also the main cause of DNA damage to the skin that is a prerequisite for most skin cancers. UVB at the Earth's surface depends on many physical and temporal factors such as latitude, altitude, season, and weather. Personal, cultural, and behavioral factors are also important. These include skin melanin, clothing, body surface area exposed, holiday habits, and sunscreen use. There is considerable disagreement in the literature about the role of some of these factors, possibly because some studies have been done by researchers with little understanding of photobiology. It can be argued that vitamin D supplementation obviates the need for solar exposure, but many studies have shown little benefit from this approach for a wide range of health outcomes. There is also increasing evidence that such exposure offers health benefits independently of vitamin D: the most important of which is blood-pressure reduction. In any case, public health advice must optimize risk versus benefit for solar exposure. It is fortunate that the individual UVB doses necessary for maintaining optimal vitamin D status are lower than those for sunburn, irrespective of skin melanin.

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Increase in serum 25-hydroxyvitamin-D3 in humans after sunbed exposures compared to previtamin D3 synthesis in vitro

Cited by 14 publications

References 22 publications

Overview on vitamin D and sunbed use

Overview on vitamin D and sunbed use

Metrology of the vitamin-D-synthetic activity of UV lamps

Physical Determinants of Vitamin D Photosynthesis: A Review

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