Increase in plasma Tyr-MIF-1-like immunoreactivity after hypophysectomy is robust and reversible by corticosterone

Melanocyte‐Stimulating Hormone Release‐Inhibiting Factor‐1 (MIF‐1) Can Be Formed from Tyr‐MIF‐1 in Brain Mitochondria but Not in Brain Homogenate

“…stereospecific transport system moves Tyr-MIF-1 across the blood-brain barrier from brain to blood (Banks and Kastin, 1984;Banks et al ., 1986Banks et al ., , 1987Banks et al ., , 1990 but not blood to brain (Barrera et al, 1989;Banks and Kastin, 1994) . In blood, concentrations of Tyr-MIF-1 are increased by adrenalectomy and especially hypophysectomy (Kastin and Dickson, 1987;Kastin et al ., 1995), but hypophysectomy does not seem to affect the transport of Tyr-MIF-1 from the CNS (authors' unpublished data) . Tyr-MIF-1 can also decrease protein kinase A activity (Zhang et al ., 1992) .…”