From MIF-1 to endomorphin: The Tyr-MIF-1 family of peptides

Pan, Weihong; Kastin, Abba J.

doi:10.1016/j.peptides.2007.10.006

Cited by 48 publications

(41 citation statements)

References 269 publications

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“…Both produce analgesia through G-coupled mechanism that blocks the release of pain-propagating neurotransmitters in the brain [ 5,15 ]. The so-called anti-opioid peptides from the Tyr-MIF-1 family alter these effects [ 12 ]. The results obtained confirmed that the endocannabinoid and the opioid systems mutually influenced each other during stress.…”

supporting

confidence: 61%

“…They bind to opioid receptors, but some of them have also their own specific receptors, so they exert opioid as well as anti-opioid effects [ 12 ]. Our previous experimental data also showed that MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1 have anti-opioid effects [ 13,14 ].…”

mentioning

confidence: 81%

“…The most pronounced suppression of the pain threshold was with MIF-1 administration. It is known that MIF-1 does not bind to opioid receptors and has a weak analgesic effect [ 12 ]. Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1 decreased the pain threshold after 20 min of the time investigated compared to 1 h IS.…”

mentioning

confidence: 85%

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Effects of Tyr-MIF-1 Family of Peptides on Endocannabinoid System after Immobilization Stress

Nocheva¹,

Kochev²,

Bocheva³

2013

Proceeding BAS

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Biochemical, physiological and behavioural changes take place during stress. Various stress models have been reported to induce analgesia. This is a phenomenon referred to as stress-induced analgesia (SIA). Two forms of SIA are commonly distinguished: an opioid-mediated and a non-opioid one.In the last decade special attention has been attributed to the endocannabinoid system (ECS) as a component of non-opioid SIA.The Tyr-MIF-1 peptides proved to have opioid-like as well as anti-opioid effects.It has been shown that the endogenous opioid and the endocannabinoid systems have been involved in stress-induced analgesia.We found no literature data about the effects of Tyr-MIF-1 neuropeptides on the endocannabinoid system after stress.The aim of the study was to investigate the effects on nociception of Tyr-MIF-1 peptides (MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1) on the endocannabinoid system after immobilization stress.Anandamide (CB1 agonist) and AM251 (CB1 antagonist) were used. Nociception was measured in male Wistar rats by paw-pressure and hot-plate tests. All drugs were injected intraperitoneally.The results showed that anandamide and AM251 were involved in the analgesic effects of Tyr-MIF-1 peptides after immobilization SIA. The effects are probably due to different interaction between Tyr-MIF-1 receptors and endocannabinoid ones and the different involvement of the opioid and the antiopioid component in immobilization stress.

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supporting

confidence: 61%

mentioning

confidence: 81%

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Effects of Tyr-MIF-1 Family of Peptides on Endocannabinoid System after Immobilization Stress

Nocheva¹,

Kochev²,

Bocheva³

2013

Proceeding BAS

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“…For example, activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis by stress is under tight feedback regulation that serves to restrain and terminate the response 19,27,28 . The orchestrated interplay of several neurotransmitter systems in the brain underlies the characteristic phenomenology of behavioral, endocrine, autonomic and immune responses to stress [29][30][31] . These transmitters include Corticotrophin-Releasing Hormone (CRH), vasopressin (AVP), dopamine, serotonin, norepinephrine and opioid peptides.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand stressors are a potent modulator of opioid activities. For instance, KTP and D-KTP have anti-opioid properties, since they decreased some forms of stress-induced analgesia 13,14,15,31,33 . The anti-opioid peptides are able to reduce some o f the acute opioid effects and permanently mask t he effects of exogenous and endogenous opioids.…”

Section: Discussionmentioning

confidence: 99%

Possible Anti-Stressor Effects of Kyotorphin and its Optical Isomer

Dzhambazov¹

2015

Pharmacologia

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Background and Objective: Kyotorphin (KTP), an endogenous analgesic neuropeptide in the central nervous system, is considered to be a neurotransmitter or neuromodulator. D-kyotorphin (D-KTP) is a synthetic analogue of KTP. Both peptides bind to a specific receptor and induced Met-enkephalin release. Thus, the effects of both peptides fall into two clearly identifiable groups: the ones, mediated via opioid peptides and the opioid peptideindependent ones. For a long time we have been interested in the neuromodulating properties of KTP and D-KTP in analgesia due to different types of stress. Our previous data showed that both peptides reduced stress-induced analgesia, which suggest that they may act as an anti-opioid peptides counteracting the effects of stress. During acute stress increased secretion of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) plays a key regulatory role on the basal activity of the hypothalamic-pituitary-adrenal axis and on the termination of the stress response. The aim of this study was to compare changes in ACTH and CORT concentration after various stressors, as well as after injection of KTP or D-KTP. Materials and Methods: The male Wistar rats were injected with KTP or D-KTP immediately after exposure of acute immobilization, cold and heat stresses. After decapitation plasma ACTH and CORT were assayed by a double antibody radioimmunoassay method. Results and Conclusion: The various stressors applied seem to induce a different response of the HPA system as judged by quantitative changes in ACTH and CORT release. In addition, this study points to KTP and its synthesized optical isomer D-KTP as a possible antistressor substances with potential clinical importance in the context of stress-related disorders, since they inhibited stress-induced elevations in two investigated hormones helping the organism to reach homeostatic level. Further studies are needed to understand the exact role of KTP in stress response.

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Zwitterion‐Catalyzed Amino‐Dibromination of Nitroalkenes: Scope, Mechanism, and Application to The Synthesis of Glycinamides

Lam

et al. 2021

Asian J Org Chem

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From MIF-1 to endomorphin: The Tyr-MIF-1 family of peptides

Cited by 48 publications

References 269 publications

Effects of Tyr-MIF-1 Family of Peptides on Endocannabinoid System after Immobilization Stress

Effects of Tyr-MIF-1 Family of Peptides on Endocannabinoid System after Immobilization Stress

Possible Anti-Stressor Effects of Kyotorphin and its Optical Isomer

Zwitterion‐Catalyzed Amino‐Dibromination of Nitroalkenes: Scope, Mechanism, and Application to The Synthesis of Glycinamides

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