Increase in myelin basic protein in CSF after brain surgery

Alling, Christer; Karlsson, Börje W.; Vãllfors, Bertil

doi:10.1007/bf00313336

Cited by 43 publications

(14 citation statements)

References 10 publications

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“…Glioblastoma multiforme has also reported at the site of metal splinter injury [15] and gunshot injuries complicated with infectious processes may be responsible for the development of posttraumatic GBM after many years [24]. Glioblastoma multiforme may also develop after neurosurgical operations due to the collection of myelin basic protein in the brain [25].…”

Section: Discussionmentioning

confidence: 99%

Post-Traumatic Glioblastoma Multiforme: A Case Report

Coşkun

Coskun

Gürsan

et al. 2011

EAJM

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Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A 65-year-old man was admitted because of right sided hemiplegia, epilepsy and changes in consciousness due to a malignant glial tumor. He had been operated on for a left calvarial depression fracture caused by cerebral laceration thirty-five years before. Radiologic imaging revealed a large contrast-enhanced mass lesion at the left frontotemporoparietal junction under the depression site. The patient underwent urgent surgery, and radical excision of the mass was achieved. The histopathologic diagnosis was a highgrade glial tumor. Although the possibility of a pre-existing tumor rather than a trauma-induced tumor is very high, the presented case suggests that traumatic cerebral lesions may also be a predisposing factor for the development of malignant glial tumors. Key Words: Brain injury, Glial cell tumors, Trauma ÖzetTravma sonrasında malign glioma gelişimi çok nadir gelişen bir durumdur. Atmışbeş yaşındaki erkek hasta malign glial tümör nedeniyle gelişen sağ hemipleji, epilepsi ve bilinç kaybı ile kliniğimize kabul edildi. Hasta 35 yıl önce sol kalvaryal depresyon fraktürüne bağlı serebral laserasyon nedeniyle ameliyat edilmiştir. Radyolojik görün-tülemede depresyon alanının altında sol frontotemporoparyetal loblarda kontrast tutan büyük bir kitle lezyonu göstermekteydi. Hasta acil operasyona alınarak radikal kitle eksizyonu uygulandı. Önceden mevcut bir tümör olma olasılığı travma kaynaklı tümörden çok yük-sek olmasına rağmen, sunulan olguda travmatik beyin lezyonu malign glial tümör gelişiminde predispozan bir faktör olabilir.

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Section: Discussionmentioning

confidence: 99%

Post-Traumatic Glioblastoma Multiforme: A Case Report

Coşkun

Coskun

Gürsan

et al. 2011

EAJM

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“…20 The assay of myelin-basic protein was performed with a radioimmunological method as described by Karlsson and Alling 23 using cold ethanol in the precipitation step. Increased levels of plasma proteins, including IgG in CSF, has not been found to correlate with increasing levels of myelin-basic protein.…”

Section: Myelin Basic Proteinmentioning

confidence: 99%

“…19 after brain surgery, 20 and also in acute-CVD patients. 21 The purpose of the present study was to measure the CSF concentrations of MBP, tau-fraction, albumin, IgG and transferrin in a well-defined clinical sample of acute-CVD patients, to demonstrate the significance of the substances as markers of acute CVD, and to correlate these markers to the type and size of brain lesion and to the patient's clinical outcome.…”

mentioning

confidence: 99%

Brain and plasma proteins in spinal fluid as markers for brain damage and severity of stroke.

Strand¹,

Alling²,

Karlsson³

et al. 1984

Stroke

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“…26 Glioblastoma multiformes may also develop after neurosurgical operations due to the collection of myelin basic protein in the brain. 1 Manuelidis 17 has stated that bleeding, edema and scars should be distinguished from traumatic injury. A contrast CT/MR done soon after resolution of the traumatic contusion should not reveal a mass lesion.…”

Section: Discussionmentioning

confidence: 99%