Increase in magnesium plasma level after orally administered trimagnesium dicitrate

Wilimzig, C.; Latz, R.; Vierling, W.; Mutschler, E.; Trnovec, T.; Nyulassy, S

doi:10.1007/bf00226334

Cited by 18 publications

(11 citation statements)

References 13 publications

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“…Another finding of the present study was the confirmation of previous studies' results of circadian rhythm changes of electrolyte serum levels [12][13][14] . The levels of phosphate in serum were lowest in the morning hours and began to increase slowly during midday and afternoon before declining again during the evening and night hours ( fig.…”

Section: Discussionsupporting

confidence: 81%

Glycerophosphate Is Interchangeable with Inorganic Phosphate in Terms of Safety and Serum Pharmacokinetics

et al. 2011

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Objective: The primary aim of the present investigation was to determine and compare the pharmacokinetic (PK) profiles of inorganic phosphate in serum and urine after intravenous administration of sodium glycerophosphate and inorganic sodium phosphate. Additionally, study product safety profiles were evaluated. Subjects and Methods: In total, 27 healthy, white volunteers (17 male/10 female) were enrolled in this double-blinded, randomized, 2-sequence, crossover study and were assigned to receive an organic test drug (sodium glycerophosphate) and an inorganic reference preparation (sodium phosphate) on 2 occasions. Validated analytical methods were used, and concentrations of total inorganic phosphate in serum and urine were determined over 24 h following a single 4-hour continuous intravenous infusion of test and reference drugs at a dose of 80 mmol. Study days were separated by washout periods of 7 days. An analysis of variance, based on population means and 90% confidence intervals (CIs), was used for testing bioequivalence (BE; range 0.8–1.25) between investigational products. Results: The geometric means of the ratio of the point estimates and corresponding 90% CIs for the area under the concentration-versus-time curve of inorganic serum phosphate from 0 to 24 h (AUC_0–24), the phosphate’s maximum concentration in serum (C_max) and the total amount of inorganic phosphate excreted in urine over 24 h corrected for individual baseline values (Ae_{0–24 bc}) were estimated. The test/reference ratios for inorganic phosphate were 1.04 (CI 1.00–1.07), 0.85 (CI 0.84–0.87) and 0.84 (CI 0.77–0.92) for AUC_0–24, C_max in serum and Ae_{0–24 bc} in urine, respectively. Hence, standard BE criteria were met for AUC_0–24 and C_max in serum, while Ae_{0–24 bc} marginally failed to demonstrate BE. After drug administration, a total of 15 subjects reported the occurrence of at least 1 treatment emergent adverse event (AE). All AEs were classified as mild to moderate in severity, and the two treatment groups were equally affected. No serious AEs occurred. Conclusion: The serum PK profiles of inorganic phosphate were almost superimposable following intravenous administration of equimolar doses of test and reference drugs. Thus, we conclude that the two study drugs are essentially similar in terms of serum PK profiles, safety and tolerability.

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Section: Discussionsupporting

confidence: 81%

Glycerophosphate Is Interchangeable with Inorganic Phosphate in Terms of Safety and Serum Pharmacokinetics

et al. 2011

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“…We assumed that the healthy participants were in Mg equilibrium in relation to tissue uptake and tissue release of Mg. Otherwise, urinary Mg excretion may not reflect the absorbed Mg and constitute a valuable tool for the assessment of Mg uptake [10,31,32]. As shown in fig.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Pharmacokinetic Profile of Oral Magnesium Hydroxide

Dolberg

Nielsen

Dahl

2017

Basic Clin Pharma Tox

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Despite the presumption of a beneficial effect of magnesium (Mg) supplementation on various diseases, little is known concerning the pharmacokinetics of Mg hydroxide. This study was designed to provide a pharmacokinetic profile of Mg hydroxide after a single oral dose. Ten healthy male adults participated in this cross-over study with three 24-hr study days. Interventions were (i) none (baseline), (ii) oral intake of three (3 × 360 mg) tablets of Mg hydroxide (Mablet ) and (iii) IV bolus infusion of 2 g Mg sulphate (index drug). Blood samples were collected before the single dose, after (i.e. after treatment administration) 15, 30, 60, 90 and 120 min. and after 3, 4, 6, 8, 12 and 24 hr. Urine was collected in four 6-hr periods per study day. Blood (N = 10) and urine (N = 6) Mg were analysed by descriptive statistics. Bioavailability was 14.9% (CI: 8.3; 26.8), blood clearance was 5.1 L/hr (CI: 2.1; 17.0), apparent volume of distribution was 60.2 L (CI: 35.6; 102.0), elimination constant was 0.08 per hour (CI: 0.05; 0.14), half-life was 8.3 hr (CI: 4.8; 14.1), C was 0.11 mmol/L (CI: 0.07; 0.14), and AUC was 92.3 mmol/L × min. (CI: 45.5; 139.1). Urine Mg excretion augmented by 17.7% (CI: 8.9; 35.0) from baseline. No severe side effects were observed. The bioavailability of Mg hydroxide was 15%, and it constitutes a clinically relevant option for oral Mg supplementation. No severe side effects were seen.

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“…Studies on bioavailability can be made by determining the plasma level of Mg although the range between normal homeostasis and a deficiency is very small. A further complication is that the plasma level of Mg expresses circadian variation with peak levels around 1000 and 2000 hours [13]. This variation, which is around 6%, is present also after supplementation with Mg. Information on the Mg homeostasis can also be obtained by measuring the urinary excretion over a 24 hour period, although no conclusion can be drawn regarding the total amount of Mg retained in the body.…”

Section: Methodsmentioning

confidence: 99%

Bioavailability of Magnesium Salts – A Review

Rylander¹

2014

J. Pharm. Nutr. Sci.

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Background: Magnesium supplementation is of value in several different medical disorders. Several kinds of Mg-salts are commercially available. Purpose: This review evaluates their bioavailability criteria such as solubility, urinary excretion, and plasma levels of magnesium from studies of different Mg-salts. Conclusion: Although methodology differences were large, the results consistently demonstrate a better bioavailability for Mg-citrate.

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Increase in magnesium plasma level after orally administered trimagnesium dicitrate

Cited by 18 publications

References 13 publications

Glycerophosphate Is Interchangeable with Inorganic Phosphate in Terms of Safety and Serum Pharmacokinetics

Glycerophosphate Is Interchangeable with Inorganic Phosphate in Terms of Safety and Serum Pharmacokinetics

Pharmacokinetic Profile of Oral Magnesium Hydroxide

Bioavailability of Magnesium Salts – A Review

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