Increase in emergency admissions to hospital for children aged under 15 in England, 1999-2010: national database analysis

Gill, Peter; Goldacre, Michael J; Mant, David; Heneghan, Carl; Thomson, Anne; Seagroatt, Valerie; Harnden, Anthony

doi:10.1136/archdischild-2012-302383

Cited by 142 publications

(173 citation statements)

References 22 publications

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“…Our models are sensitive to the number of positive laboratory tests; therefore, our results could be affected by a change in the relative sensitivity or specificity of the assays for the different pathogens over time, although the majority of laboratories have been using RT‐PCR for most of the study period. However, from 1999 to 2010, there has been an increase of 28% in emergency hospital admissions in children <5 years of age, particularly admissions for acute illness, and the annual number of hospital admissions due to bronchiolitis in young children in the UK has also increased sevenfold between 1979 and 2011 8, 19. This evidence suggests that the increase is not due to an increase in the severity of infection, nor the virulence of RSV in the age group, because paediatric intensive care admission rates have changed little from 2004 to 2012 8.…”

Section: Discussionmentioning

confidence: 99%

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Reeves

Hardelid

Gilbert

et al. 2017

Influenza Resp Viruses

100

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BackgroundRespiratory syncytial virus (RSV) is a leading cause of hospital admission in young children. With several RSV vaccines candidates undergoing clinical trials, recent estimates of RSV burden are required to provide a baseline for vaccine impact studies.ObjectivesTo estimate the number of RSV‐associated hospital admissions in children aged <5 years in England over a 5‐year period from 2007 using ecological time series modelling of national hospital administrative data.Patients/MethodsMultiple linear regression modelling of weekly time series of laboratory surveillance data and Hospital Episode Statistics (HES) data was used to estimate the number of hospital admissions due to major respiratory pathogens including RSV in children <5 years of age in England from mid‐2007 to mid‐2012, stratified by age group (<6 months, 6‐11 months, 1‐4 years) and primary diagnosis: bronchiolitis, pneumonia, unspecified lower respiratory tract infection (LRTI), bronchitis and upper respiratory tract infection (URTI).ResultsOn average, 33 561 (95% confidence interval 30 429‐38 489) RSV‐associated hospital admissions in children <5 years of age occurred annually from 2007 to 2012. Average annual admission rates were 35.1 (95% CI: 32.9‐38.9) per 1000 children aged <1 year and 5.31 (95% CI: 4.5‐6.6) per 1000 children aged 1‐4 years. About 84% (95% CI: 81‐91%) of RSV‐associated admissions were for LRTI. The diagnosis‐specific burden of RSV‐associated admissions differed significantly by age group.Conclusions RSV remains a significant cause of hospital admissions in young children in England. Individual‐level analysis of RSV‐associated admissions is required to fully describe the burden by age and risk group and identify optimal prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Reeves

Hardelid

Gilbert

et al. 2017

Influenza Resp Viruses

100

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“…In several localities, secondary data sources have been used to study hospitalizations in large populations, (24,25) including children. (2,4) …”

Section: Discussionmentioning

confidence: 99%

Hospitalizações de crianças por condições evitáveis no Estado do Paraná: causas e tendência

et al. 2017

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Objective: To analyze the trends of hospitalizations for ambulatory care-sensitive conditions, according to the main causes among children under five years old. Method: Ecological time-series study carried out with data from the Hospital Information System of the State of Parana. The analysis was based on hospitalization rates and polynomial regression models according to age and cause. Results: The most frequent causes were pneumonia, gastroenteritis, asthma, kidney and urinary tract infection and nutritional disorders. Hospitalizations for pneumonia, asthma and nutritional deficiencies decreased among children under five and hospitalizations rates for gastroenteritis remained stable. There was an increase in hospitalization rates for kidney and urinary tract infection in all ages. Conclusion: Hospitalization for care-sensitive conditions among children under five years presented an increasing trend only for children under one year old. Hospitalizations for pneumonia, gastroenteritis, asthma and nutritional deficiencies showed a decreasing trend. ResumoObjetivo: Analisar a tendência das hospitalizações por condições sensíveis à atenção primária, segundo principais causas em menores de cinco anos. Métodos: Estudo de séries temporais do tipo ecológico realizado com dados do Sistema de Informação Hospitalar do Estado do Paraná. A análise ocorreu a partir das taxas de hospitalização e de modelos de regressão polinomial segundo idade e causa. Resultados: As causas mais frequentes foram pneumonias, gastrenterites, asma, infeção no rim e trato urinário e deficiências nutricionais. As hospitalizações por pneumonia, asma e deficiências nutricionais em menores de cinco anos reduziram e por gastroenterites mantiveram-se estáveis. Houve aumento nas taxas de hospitalização por infecção no rim e trato urinário em todas as idades. Conclusão: A tendência de hospitalização por condições sensíveis em menores de cinco anos foi crescente apenas para as crianças menores de um ano. As hospitalizações por pneumonias, gastroenterites, asma e deficiências nutricionais apresentaram tendência decrescente.

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“…17 Such prolonged inpatient stays would allow chronically malnourished children a sustained period of recovery on a hospital diet that more than met their nutritional needs, in a ward environment that emphasized cleanliness. 9,10,18 We also learn how many of these patients were described as "cured," even with conditions that would be considered quite incurable today.…”

Section: Children In Hospitals Before There Were Children' S Hospitalsmentioning

confidence: 99%

Children in Hospitals Before There Were Children’s Hospitals

Williams

Sharma

2014

Pediatrics

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Increase in emergency admissions to hospital for children aged under 15 in England, 1999-2010: national database analysis

Cited by 142 publications

References 22 publications

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Estimating the burden of respiratory syncytial virus (RSV) on respiratory hospital admissions in children less than five years of age in England, 2007‐2012

Hospitalizações de crianças por condições evitáveis no Estado do Paraná: causas e tendência

Children in Hospitals Before There Were Children’s Hospitals

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