Increase in Circulating Endothelial Cells in Patients with Primary Chronic Venous Insufficiency: Protective Effect of Ginkor Fort in a Randomized Double-Blind, Placebo-Controlled Clinical Trial

Janssens, Dominique; Michiels, Carine; Guillaume, Geneviève; Cuisinier, Bernard; Louagie, Yves; Remacle, José

doi:10.1097/00005344-199901000-00002

Cited by 38 publications

(13 citation statements)

References 14 publications

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“…In a randomized double-blind placebo-controlled clinical trial Ginkgo biloba extract, troxerutine, and heptaminol (Ginkor Fort) were tested for their venotropic protective effect in patients with CVI. The treated patient had decreased circulating endothelial cells, supporting venoprotective effects of these compounds against the endothelial cell injury associated with venous disease [92]. Daflon 500, a combination of active venotonic diosmin and the inactive compound hesperidin, is formulated as a micronized purified flavonoid fraction for increased absorption.…”

Section: Management Of Varicose Veinsmentioning

confidence: 88%

Matrix Metalloproteinases in Venous Tissue Remodeling and Varicose Vein Formation

Raffetto¹,

Khalil²

2008

CVP

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Matrix metalloproteinases (MMPs) play a major role in extracellular matrix (ECM) turnover under both physiological and pathological conditions. Studies on venous tissues from experimental animals and humans identified several MMP subtypes, and showed significant changes in the expression and activity of specific MMPs during vein wall remodeling. Also, significant research has focused on the role of MMPs in chronic venous disease (CVD) and varicose vein formation in the lower extremities and their progression to thrombophlebitis and venous leg ulcer. Several hypotheses have been forwarded regarding the pathophysiological mechanisms underlying the relation between MMPs and the formation, progression and complications of varicose veins. The effects of MMPs on ECM degradation could result in significant venous tissue remodeling and degenerative and structural changes in the vein wall, leading to venous dilation and valve dysfunction. MMPs may also induce early changes in the endothelium and venous smooth muscle function in the absence of significant ECM degradation or structural changes in the vein wall. In addition, evidence suggests increased activity of MMPs in the advanced stages of chronic venous insufficiency (CVI) associated with skin changes and leg ulceration as well as in the wound fluid environment. Several pharmacological therapies and surgical strategies are being utilized in the management of varicose veins, with variable success and recurrence rates. Inhibition of MMPs may represent a novel therapeutic intervention to limit the progression of varicose veins to CVI and leg ulceration.

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Section: Management Of Varicose Veinsmentioning

confidence: 88%

Matrix Metalloproteinases in Venous Tissue Remodeling and Varicose Vein Formation

Raffetto¹,

Khalil²

2008

CVP

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“…Janssens et al found that in patients treated with GBE the number of circulating endothelial cells was decreased by the end of four weeks of treatment (20). It is suggested that GBE affects endothelium in a way that is potentially beneficial in chronic venous insufficiency.…”

Section: Clinical Use In Venous Insufficiencymentioning

confidence: 99%

Clinical Use and Molecular Mechanisms of Action of Extract of Ginkgo biloba Leaves in Cardiovascular Diseases

Wei

Chai

Lin

et al. 2004

Cardiovascular Drug Reviews

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Ginkgo biloba is one of the oldest living tree species that has been referred to as a living fossil. Extract from Ginkgo biloba leaves (GBE) is among the most commonly used herbal drugs and is popularized for its alleged tonic effect and possible curative and restorative properties. There is an increasing evidence of the potential role of GBE in treating cardiovascular diseases. We examined the history of GBE usage and reviewed the literature on its effects on the cardiovascular system. In the extensive studies involving cell cultures and animal models, GBE has been shown to exert its action through diverse mechanisms. GBE has been reported to have antioxidatant properties, to modify vasomotor function, to reduce adhesion of blood cells to endothelium, to inhibit activation of platelets and smooth muscle cells, to affect ion channels, and to alter signal transduction. In addition, relevant clinical trials with CBE are being carried out, particularly in the treatment of arterial and venous insufficiency and in the prevention of thrombosis. Finally, the controversial clinical findings and the possible adverse interactions between GBE and other drugs are discussed. This review underscores the potential benefits of Ginkgo biloba in cardiovascular diseases, highlights the gaps in our current research, and suggests the necessity for more rigorous systematic investigation of cardiovascular properties of CBE.

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“…C irculating endothelial cells (CEC) have been described in various conditions with vascular injury, including chronic renal failure and systemic vasculitis (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). These studies indicate the existence of two types of cells in peripheral blood: endothelial progenitor cells (EPC) that are bone marrow derived and inflammatory endothelial cells (IEC) that are thought to be detached from the vessel walls and enter the circulation as a result of vascular injury.…”

mentioning

confidence: 99%

Circulating Inflammatory Endothelial Cells Contribute to Endothelial Progenitor Cell Dysfunction in Patients with Vasculitis and Kidney Involvement

Holmén¹,

Elsheikh

Stenvinkel

et al. 2005

Journal of the American Society of Nephrology

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Increase in Circulating Endothelial Cells in Patients with Primary Chronic Venous Insufficiency: Protective Effect of Ginkor Fort in a Randomized Double-Blind, Placebo-Controlled Clinical Trial

Cited by 38 publications

References 14 publications

Matrix Metalloproteinases in Venous Tissue Remodeling and Varicose Vein Formation

Matrix Metalloproteinases in Venous Tissue Remodeling and Varicose Vein Formation

Clinical Use and Molecular Mechanisms of Action of Extract of Ginkgo biloba Leaves in Cardiovascular Diseases

Circulating Inflammatory Endothelial Cells Contribute to Endothelial Progenitor Cell Dysfunction in Patients with Vasculitis and Kidney Involvement

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