Increase in Antimicrobial Resistance in Bacteria Isolated from Stranded Marine Mammals of the Northwest Atlantic

Wallace, Courtney C.; Yund, Philip O.; Ford, Tim; Matassa, Keith; Bass, Anna L.

doi:10.1007/s10393-013-0842-6

Cited by 33 publications

(34 citation statements)

References 35 publications

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“…Enterobacteriaceae are frequently found in the gut flora of reptiles [39,40]. Previously known as commensal bacteria, today Enterobacteriaceae are considered as cause of serious illness worldwide, mainly in immunocompromised patients [41], and suggested as potential secondary invaders of infections in marine animals [42]. Enterobacter spp.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles

Blasi¹,

Migliore

Mattei³

et al. 2020

Antibiotics

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Sea turtles have been proposed as health indicators of marine habitats and carriers of antibiotic-resistant bacterial strains, for their longevity and migratory lifestyle. Up to now, a few studies evaluated the antibacterial resistant flora of Mediterranean loggerhead sea turtles (Caretta caretta) and most of them were carried out on stranded or recovered animals. In this study, the isolation and the antibiotic resistance profile of 90 Gram negative bacteria from cloacal swabs of 33 Mediterranean wild captured loggerhead sea turtles are described. Among sea turtles found in their foraging sites, 23 were in good health and 10 needed recovery for different health problems (hereafter named weak). Isolated cloacal bacteria belonged mainly to Enterobacteriaceae (59%), Shewanellaceae (31%) and Vibrionaceae families (5%). Although slight differences in the bacterial composition, healthy and weak sea turtles shared antibiotic-resistant strains. In total, 74 strains were endowed with one or multi resistance (up to five different drugs) phenotypes, mainly towards ampicillin (~70%) or sulfamethoxazole/trimethoprim (more than 30%). Hence, our results confirmed the presence of antibiotic-resistant strains also in healthy marine animals and the role of the loggerhead sea turtles in spreading antibiotic-resistant bacteria.

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Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles

Blasi¹,

Migliore

Mattei³

et al. 2020

Antibiotics

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“…) and that AMRB prevalence has been alarmingly increasing over the last decade (Wallace et al . ). Furthermore, with the global loss of natural wetlands, waterbirds have become increasingly dependent on alternative and artificial habitats including wastewater treatment wetlands (Murray & Hamilton ), which could favour the transmission to wild birds of AMRB of human origin.…”

Section: Habitats: Where Is the Resistance?mentioning

confidence: 97%

“…As discussed in part II, water seems to play a major role in the dispersal of antibiotics and AMRB to natural ecosystems. As an illustration of this role, studies carried out on marine mammals to date have shown that they carry highly diverse AMRB (Schaefer et al 2009) and that AMRB prevalence has been alarmingly increasing over the last decade (Wallace et al 2013). Furthermore, with the global loss of natural wetlands, waterbirds have become increasingly dependent on alternative and artificial habitats including wastewater treatment wetlands (Murray & Hamilton 2010), which could favour the transmission to wild birds of AMRB of human origin.…”

Section: Habitats: Where Is the Resistance?mentioning

confidence: 99%

Antimicrobial resistance in wildlife

Vittecoq

Godreuil

Prugnolle

et al. 2016

Journal of Applied Ecology

201

197

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International audience1. The spread of antimicrobial resistance is of major concern for human health and leads togrowing economic costs. While it is increasingly hypothesized that wildlife could play animportant role in antimicrobial-resistant bacteria dynamics, empirical data remain scarce.2. The present work builds on a systematic review of the available data in order to highlightthe main information we have and to suggest research pathways that should be followed ifwe aim to fill the gaps in our current knowledge.3. To achieve this goal, we address four questions: (i) Which resistant bacteria are the mostfrequently observed in wildlife? (ii) How are resistant bacteria exchanged between wildlife andthe other hosts involved? (iii) In which habitats are those resistant bacteria found? (iv) Areresistances associated with certain ecological traits of the host?4. Synthesis and applications. We highlight the strong link existing between the impact ofhuman activities on natural habitats and the carriage of antimicrobial-resistant bacteria bywildlife. Furthermore, we underline that omnivorous, anthropophilic and carnivorous speciesare at high risk of being carriers and potentially spreaders of antimicrobial-resistant bacteria.Identifying among those groups key sentinel species may be of particular interest to implementecosystem contamination surveillance. Finally, we discuss possible exchange routes forantimicrobial-resistant bacteria between humans and wildlife. Considering that water is ofmajor importance in those exchanges, a critical way to control antimicrobial resistance spreadmay be to limit aquatic environment contamination by antimicrobial-resistant bacteria andantibiotics

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“…Thus, in both marine and terrestrial environments, wildlife can come into direct contact with most antibiotics, even at sub-inhibitory concentrations [10], leading to the selection of antibiotic-resistant microbiota. In this context, wildlife represents a potential reservoir, or vector, of resistant pathogens and ARGs [1,11,12]; therefore, in the study of the spread of the AMR, it may be useful to evaluate the role of migratory wildlife species, which can carry a resistant microbiota.…”

Section: Introductionmentioning

confidence: 99%

Is Caretta Caretta a Carrier of Antibiotic Resistance in the Mediterranean Sea?

et al. 2020

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Sea turtles can be considered a sentinel species for monitoring the health of marine ecosystems, acting, at the same time, as a carrier of microorganisms. Indeed, sea turtles can acquire the microbiota from their reproductive sites and feeding, contributing to the diffusion of antibiotic-resistant strains to uncontaminated environments. This study aims to unveil the presence of antibiotic-resistant bacteria in (i) loggerhead sea turtles stranded along the coast of Sicily (Mediterranean Sea), (ii) unhatched and/or hatched eggs, (iii) sand from the turtles’ nest and (iv) seawater. Forty-four bacterial strains were isolated and identified by conventional biochemical tests and 16S rDNA sequencing. The Gram-negative Aeromonas and Vibrio species were mainly found in sea turtles and seawater samples, respectively. Conversely, the Gram-positive Bacillus, Streptococcus, and Staphylococcus strains were mostly isolated from eggs and sand. The antimicrobial resistance profile of the isolates revealed that these strains were resistant to cefazolin (95.5%), streptomycin (43.2%), colistin and amoxicillin/clavulanic acid (34.1%). Moreover, metagenome analysis unveiled the presence of both antibiotic and heavy metal resistance genes, as well as the mobile element class 1 integron at an alarming percentage rate. Our results suggest that Caretta caretta could be considered a carrier of antibiotic-resistant genes.

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Increase in Antimicrobial Resistance in Bacteria Isolated from Stranded Marine Mammals of the Northwest Atlantic

Cited by 33 publications

References 35 publications

Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles

Antibiotic Resistance of Gram-Negative Bacteria from Wild Captured Loggerhead Sea Turtles

Antimicrobial resistance in wildlife

Is Caretta Caretta a Carrier of Antibiotic Resistance in the Mediterranean Sea?

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