Incorporation of zinc oxide nanoparticles into chitosan-collagen 3D porous scaffolds: Effect on morphology, mechanical properties and cytocompatibility of 3D porous scaffolds

Ullah, Saleem; Zainol, Ismail; Idrus, Ruszymah Bt Hj

doi:10.1016/j.ijbiomac.2017.06.080

Cited by 58 publications

(22 citation statements)

References 31 publications

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“…Metallic nanoparticle loaded scaffolds possess peculiar properties such as low toxicity and antibacterial activity, making them promising candidates for the treatment of infected wounds. Thanks to their peculiar properties, nanoparticles (i.e., silver [ 53 , 66 , 67 , 68 ], copper [ 69 ] and zinc oxide nanoparticles [ 70 , 71 ]) seem a valid option to control bacterial infections, overcoming antibiotic-resistance mechanisms owing to their unique and advantageous physio-chemical properties. In fact, the interaction of metallic nanoparticles and microorganisms causes the production of reactive oxygen species (ROS), damaging bacterial cells.…”

Section: Medical Devices For Wound Healingmentioning

confidence: 99%

“…Native skin shows tensile strength values between 5.0 and 30.0 MPa, a Young’s modulus in the range of 4.6–20.0 MPa and elongation at break of about 35.0–115.0%; these values are wide since the skin mechanical properties vary depending on the body area, and the ageing (thinner and less flexible [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]). The ability of the scaffold to maintain its integrity during grafting is related to the tensile strength, while the performance of the scaffold upon grafting is related to elongation and the Young’s modulus.…”

Section: Definition Of the Quality Attributesmentioning

confidence: 99%

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Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

et al. 2020

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Chronic wounds, such as pressure ulcers, diabetic ulcers, venous ulcers and arterial insufficiency ulcers, are lesions that fail to proceed through the normal healing process within a period of 12 weeks. The treatment of skin chronic wounds still represents a great challenge. Wound medical devices (MDs) range from conventional and advanced dressings, up to skin grafts, but none of these are generally recognized as a gold standard. Based on recent developments, this paper reviews nanotechnology-based medical devices intended as skin substitutes. In particular, nanofibrous scaffolds are promising platforms for wound healing, especially due to their similarity to the extracellular matrix (ECM) and their capability to promote cell adhesion and proliferation, and to restore skin integrity, when grafted into the wound site. Nanotechnology-based scaffolds are emphasized here. The discussion will be focused on the definition of critical quality attributes (chemical and physical characterization, stability, particle size, surface properties, release of nanoparticles from MDs, sterility and apyrogenicity), the preclinical evaluation (biocompatibility testing, alternative in vitro tests for irritation and sensitization, wound healing test and animal wound models), the clinical evaluation and the CE (European Conformity) marking of nanotechnology-based MDs.

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Section: Medical Devices For Wound Healingmentioning

confidence: 99%

Section: Definition Of the Quality Attributesmentioning

confidence: 99%

Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

et al. 2020

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“…In these situations, it is convenient to use the intracerebral route to guarantee the correct implantation in the therapeutic target (Bible et al, 2009b;Ullah et al, 2017). For this route, it is necessary to use cannulas, in the cases of solid biomaterials or Hamilton syringes for the administration of nanoparticles (Ullah et al, 2017), microspheres (Bible et al, 2012), liquid neurospheres or hydrogels, which are administered before polymerization. This last pharmaceutical form has acquired great interest in in vivo studies, due to its easy and minimally invasive administration.…”

Section: Choosing Administration Routementioning

confidence: 99%

Neurorestoration Approach by Biomaterials in Ischemic Stroke

et al. 2020

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BACKGROUND Stroke is one of the most important health problems worldwide. Ischemic stroke (IS) constitutes 85-90% of the casuistry among the types of stroke and is the leading cause of disability in people over 65 years of age worldwide (Ghuman and Modo, 2016). Due to the epidemiological importance and the big socioeconomic expenditure involved, it is priority advance in its prevention, control, and treatment (Kalaria et al., 2016; Benjamin et al., 2017). The ischemic injury is caused by an interruption of blood supply in one or more cerebral blood vessels triggering a set of dynamic processes that affect all brain cells and extracellular matrix (ECM) deteriorating the "glioneurovascular niche" (Boisserand et al., 2016). The pathophysiology of IS lies in the restriction or reduction of the supply of oxygen, glucose, and nutrients in the affected brain area. The ischemic cascade begins while there is arterial obstruction causing accidental cell death of core cells damaging tissue irreversibly. This process is accompanied by events of glutamate excitotoxicity, oxidative stress, and neuroinflammation, which affect the homeostatic functioning of the neurons in the affected tissue. The combination of all of them induces permanent brain lesions (Taylor et al., 2008; Thundyil and Lim, 2015; Thornton et al., 2017). However, there are regions near the nucleus or ischemic penumbra (IP) that have had access to a collateral blood circulation, being able to partially counteract the energy deficit (Fisher and Albers, 2013; Gavaret et al., 2019).

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“…nZnO shows proangiogenic activity by producing reactive oxygen species (ROS) (Ahtzaz et al, 2017), and promote osteogenesis by releasing Zn 2+ ions (Laurenti & Cauda, 2017). It has been reported that attachment, spreading, proliferation, and infiltration of the cells have been improved by the addition of n-ZnO to the scaffolds (Ullah, Zainol, & Idrus, 2017). Furthermore, these nanoparticles indicated good biocompatibility, osteoconductivity, and antibacterial properties (Nasajpour et al, 2018).…”

mentioning

confidence: 99%

The effect of modified electrospun PCL‐nHA‐nZnO scaffolds on osteogenesis and angiogenesis

Rahmani

Hashemi‐Najafabadi

Eslaminejad

et al. 2019

J Biomedical Materials Res

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Large bone defects treatment is one of the challenges in current bone tissue engineering approaches. Various strategies have been proposed to address this issue, among which, prevascularization by coculturing of angiogenic and osteogenic cells on the scaffolds can alleviate this problem. In the present study, modified fibrous scaffolds were prepared by electrospinning and subsequent ultrasonication of polycaprolactone (PCL) containing nano‐hydroxyapatite (n‐HA), with/without nano‐zinc oxide (n‐ZnO), and polyethylene oxide [PEO] as a sacrificial agent. The physical, mechanical, and chemical characteristics of the scaffolds were evaluated. The results showed the presence of n‐ZnO, which in turn increased Young's module of the scaffolds from 5.5 ± 0.67 to 6.7 ± 1.77 MPa. Moreover, MTT, SEM, alkaline phosphatase (ALP) activity, chicken embryo chorioallantoic membrane (CAM) assay, and real‐time RT‐PCR were utilized to investigate the biocompatibility, cell adhesion and infiltration, osteoconductivity, angiogenic properties, and expression of osteogenic and angiogenic related genes. ALP assay showed that the highest enzyme activity was noted when the modified scaffolds containing n‐ZnO were seeded with HUVEC:hBMSC at the cell ratio of 1:5. CAM assay showed induction of angiogenesis for the scaffolds containing n‐ZnO. Real‐time RT‐PCR results showed significant upregulation of angiogenic related genes. Thus, the scaffolds containing n‐ZnO may have great potential for osteogenesis and angiogenesis in tissue engineering applications.

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Incorporation of zinc oxide nanoparticles into chitosan-collagen 3D porous scaffolds: Effect on morphology, mechanical properties and cytocompatibility of 3D porous scaffolds

Cited by 58 publications

References 31 publications

Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

Neurorestoration Approach by Biomaterials in Ischemic Stroke

The effect of modified electrospun PCL‐nHA‐nZnO scaffolds on osteogenesis and angiogenesis

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