Incorporation of poly(ethylene glycol) grafted cellulose nanocrystals in poly(lactic acid) electrospun nanocomposite fibers as potential scaffolds for bone tissue engineering

Zhang, Chunmei; Salick, Max R.; Cordie, Travis; Ellingham, Tom; Dan, Yi; Turng, Lih‐Sheng

doi:10.1016/j.msec.2015.01.024

Cited by 145 publications

(69 citation statements)

References 27 publications

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“…Although low PEG content (5 wt%) can increase the flexural properties, the impact strength and elongation of the modified biocomposites were not influenced with increasing content. Figure g shows that the sample length did not significantly change with increasing PEG content compared with the unmodified biocomposites, which is in agreement with previous studies showing that PEG can improve PLA strength but had a negligible effect on the elongation . However, the 30 wt% TBC‐modified biocomposites had substantial increases of 80 and 1641% on the impact strength and elongation, respectively, compared with the unmodified biocomposites.…”

Section: Resultssupporting

confidence: 88%

Comparison between polyethylene glycol and tributyl citrate to modify the properties of wood fiber/polylactic acid biocomposites

Yang

et al. 2018

Polymer Composites

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In this work, polyethylene glycol (PEG) and tributyl citrate (TBC) are proposed to modify the properties of wood fiber (WF, 20 wt%)‐reinforced polylactide (PLA, 80 wt%) biocomposites. The reinforcing and toughening effects of these additives were systematically investigated by comparing their mechanical, thermal and rheological properties. It was found that 5 wt% TBC improved the compatibility between WF and PLA and resulted in increased tensile strength (15%) and thermal stability (4%) of the biocomposites compared with those of unmodified biocomposites. The glass transition temperature, melting temperature, and crystallinity of TBC‐modified biocomposites were lower than those of PEG biocomposites. In addition, the storage modulus, loss modulus and complex viscosity of TBC‐modified biocomposites were effectively improved at low TBC content (5–10 wt%), whereas reduced properties were obtained when the same PEG content was added. As wettability is always a problem in biocomposites, the contact angle was not changed with TBC content (up to 20 wt%), and a linear decrease was observed with a PEG content up to 30 wt%. POLYM. COMPOS., 40:1384–1394, 2019. © 2018 Society of Plastics Engineers

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Section: Resultssupporting

confidence: 88%

Comparison between polyethylene glycol and tributyl citrate to modify the properties of wood fiber/polylactic acid biocomposites

Yang

et al. 2018

Polymer Composites

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“…CNF is the most abundant natural resource on earth produced by plants and bacteria, which categorized as a linear polysaccharide . A considerable amount of attention has been given to the development of CNF‐modified materials for use in tissue engineering because of its excellent properties, such as high hydrophilicity, nanoscale dimensions, low density, good mechanical response, high availability, as well as good biodegradability and biocompatibility . CNF are always directly added into electrospun solution to fabricate nanofiber composite with improved mechanical properties and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Electrospun TPU Nanofiber Scaffold with CNF Particles by Ultrasound‐Assisted Technique for Tissue Engineering

Cui

et al. 2017

Macro Materials & Eng

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A straightforward, fast, and versatile technique is developed to fabricate nanofibrous scaffold with excellent hydrophilicity, mechanical properties, and biocompatibility for tissue engineering. The thermoplastic polyurethane (TPU) nanofiber is fabricated by utilizing electrospinning, and then its surface is modified through simply immersing it into cellulose nanofibrils (CNF) dispersion and subjecting to ultrasonication. The results show that the CNF particles are successfully absorbed on the surface of TPU nanofiber. By introducing CNF particles on the surface of TPU nanofiber, the hydrophilicity, mechanical properties of fabricated CNF‐absorbed TPU scaffold are significantly increased. Additionally, the adhesion and proliferation of human umbilical vein endothelial cells cultured on CNF‐absorbed TPU scaffold are prominently enhanced in comparison with those of cultured on TPU scaffold. These findings suggest that the ultrasound‐assisted technique opens up a new way to simply and effectively modify the surface of various scaffolds and the modified scaffold could be shown a great potential in tissue engineering.

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“…In particular, electrospun PVA [21], poly(lactic acid) (PLA) [22,23], PEO [24,25], poly(ethylene glycol) (PEG) [26], and poly( ε -caprolactone) (PCL) [27] composite fibers have been successfully reinforced by CNCs. For example, the PLGA nanofiber membranes reinforced with 7 wt % CNCs had a tensile modulus of 21.28 MPa and an ultimate strain of 89.2% ± 5.3%, which are similar to the values of human skin [28].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers

et al. 2016

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Poly (vinyl pyrrolidone) (PVP)/cellulose nanocrystal (CNC)/silver nanoparticle composite fibers were prepared via electrospinning using N,N′-dimethylformamide (DMF) as a solvent. Rheology, morphology, thermal properties, mechanical properties, and antimicrobial activity of nanocomposites were characterized as a function of material composition. The PVP/CNC/Ag electrospun suspensions exhibited higher conductivity and better rheological properties compared with those of the pure PVP solution. The average diameter of the PVP electrospun fibers decreased with the increase in the amount of CNCs and Ag nanoparticles. Thermal stability of electrospun composite fibers was decreased with the addition of CNCs. The CNCs help increase the composite tensile strength, while the elongation at break decreased. The composite fibers included Ag nanoparticles showed improved antimicrobial activity against both the Gram-negative bacterium Escherichia coli (E. coli) and the Gram-positive bacterium Staphylococcus aureus (S. aureus). The enhanced strength and antimicrobial performances of PVP/CNC/Ag electrospun composite fibers make the mat material an attractive candidate for application in the biomedical field.

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Incorporation of poly(ethylene glycol) grafted cellulose nanocrystals in poly(lactic acid) electrospun nanocomposite fibers as potential scaffolds for bone tissue engineering

Cited by 145 publications

References 27 publications

Comparison between polyethylene glycol and tributyl citrate to modify the properties of wood fiber/polylactic acid biocomposites

Comparison between polyethylene glycol and tributyl citrate to modify the properties of wood fiber/polylactic acid biocomposites

Surface Modification of Electrospun TPU Nanofiber Scaffold with CNF Particles by Ultrasound‐Assisted Technique for Tissue Engineering

Preparation and Properties of Electrospun Poly (Vinyl Pyrrolidone)/Cellulose Nanocrystal/Silver Nanoparticle Composite Fibers

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