Incorporation of palmitic acid or oleic acid into macrophage membrane lipids exerts differential effects on the function of normal mouse peritoneal macrophages

Lokesh, Belur R.; Wrann, Michael

doi:10.1016/0005-2760(84)90215-7

Cited by 48 publications

(37 citation statements)

References 27 publications

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“…Several studies have reported that unsaturated fatty acids incorporated to assays in vitro increase the phagocytosis of zymosan particles (11,27). These studies showed a high correlation between phagocytosis and membrane polyunsaturated fatty acid content.…”

Section: Measurement Of Phagocytic Activitymentioning

confidence: 83%

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The Effect of Dietary Fatty Acid Manipulation on Phagocytic Activity and Cytokine Production by Peritoneal Cells from Balb/c Mice.

Pablo

Ortega

Gallego

et al. 1998

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Section: Measurement Of Phagocytic Activitymentioning

confidence: 83%

“…Some studies have suggested that lipids may modulate the immune response by the alteration of membrane fluidity (11), production of lipid peroxides (12) and direct interaction with the cellular activation process (13).…”

mentioning

confidence: 99%

The Effect of Dietary Fatty Acid Manipulation on Phagocytic Activity and Cytokine Production by Peritoneal Cells from Balb/c Mice.

Pablo

Ortega

Gallego

et al. 1998

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Similarly, increasing the cholesterol content of membranes decreases membrane fluidity and can produce perturbations in cellular functions. For example, capping of surface immunoglobulins in lymphocytes, 8 platelet aggregability, 9 erythrcphagocytosis by macrophages, 10 and receptor binding of £-adrenergic, serotoninergic, or opiate ligands in liver cells 11 are modulated by changes in membrane lipid content and fluidity.…”

mentioning

confidence: 99%

Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys.

et al. 1989

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The mechanism by which dietary unsaturated fatty acids lower low density lipoprotein (LDL) cholesterol Is unknown. Unsaturated fatty acids incorporated into the cell membrane can increase membrane fluidity and, as a result, dramatically alter membrane-dependent cell functions. Therefore, we examined the effect of long-term dietary consumption of com oil and coconut oil with and without cholesterol In amounts equivalent to those of a typical Western diet on the degradation of human LDL by peripheral blood mononuclear cells in Cebus alblfrons monkeys. Cellular LDL degradation was dramatically enhanced In the mononuclear cells Isolated from animals fed corn oil In comparison with those from animals fed coconut oil. The addition of cholesterol to the diets resulted in a slight attenuation of LDL degradation In the corn oil group while no effect was noted In the coconut oil group. Crossover E pidemiologic studies have linked diets rich In unsaturated fatty acids to a reduction in low density lipoprotein (LDL) cholesterol, 12 but the molecular mechanism by which this phenomenon occurs remains poorly understood. A number of possible mechanisms have been suggested, including modification in: 1) de novo cholesterol synthesis, 2) cholesterol absorption from the small intestine, 3) physicochemical properties of the LDL surface coat or core, 4) cholesterol distribution between plasma and various intrahepatic pools, 5) fecal sterol or cholesterol excretion, 6) partitioning of cholesterol among "cellular" pools, 7) apolipoprotein metabolism, and 8) rates of LDL metabolism.3 -7 Recent human and animal studies strongly support increased LDL metabolism as a This work was supported in part by NIH Grants RO1 HL40411, RO1-HL3610, and HL39385, by a Grant-in-Aid from the American Heart Association, a Fellowship Grant from the American Heart Association, Massachusetts Affiliate, and NIH-NRSA Grant F32-HL07700. Joseph Loscalzo is the recipient of a Career Development Award from the NIH (K04 HL02273).Address for correspondence: Joseph Loscalzo, M.D., Ph.D., Brigham and Women's Hospital,75 Francis Street, Boston, MA 02115.Received January 17, 1989; revision accepted July 5, 1989. major factor. 347 The actual cellular mechanism by which LDL clearance is enhanced, however, remains unknown.Alterations in the bulk physical properties of plasma membranes can produce changes in membranedependent cellular functions. Dietary fatty acids readily incorporate into cell membranes and can modify the physical properties of these membranes. Increasing c/s-unsaturated fatty acyl composition increases membrane fluidity (or decreases microviscosity and order), while increasing the saturated fatty acyl composition decreases membrane fluidity. Similarly, increasing the cholesterol content of membranes decreases membrane fluidity and can produce perturbations in cellular functions. For example, capping of surface immunoglobulins in lymphocytes, 8 platelet aggregability, 9 erythrcphagocytosis by macrophages, 10 and receptor binding of £-adrenergic, serotonine...

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“…Ardawi & Newsholme (1984) reported that incubated rat-lymph-node lymphocytes utilize oleic acid at a rate of approximately 34 p,mol/h per g dry weight; macrophages also utilize fatty acids (Mahoney et al 1977;Lokesh & Wrann, 1984;Newsholme et al 1987;Calder et al 1990). Some of the oleic acid used by lymphocytes and macrophages in vitro is oxidized (Lengle et al 1978;Ardawi & Newsholme, 1984;Newsholme et al 1987;.…”

Section: Fatty Acidsmentioning

confidence: 99%

“…Some of the oleic acid used by lymphocytes and macrophages in vitro is oxidized (Lengle et al 1978;Ardawi & Newsholme, 1984;Newsholme et al 1987;. Ardawi & Newsholme (1984) reported that the proportion of oleic acid which is completely oxidized to C02 is only about 1% of the total utilized by isolated mesenteric-lymph-node lymphocytes incubated for 60 min and calculated that for peritoneal macrophages cultured for 80 h 2.5% of the utilized oleic acid is oxidized; in these conditions most of the fatty acid utilized is incorporated into phospholipids and triacylglycerols (Ardawi & Newsholme, 1984;Lokesh & Wrann, 1984;. Despite the low rate of oleic acid oxidation, it was calculated that fatty acid oxidation contributes more than 30% to the 0 2 consumption of isolated lymphocytes (Ardawi & Newsholme,198.5).…”

Section: Fatty Acidsmentioning

confidence: 99%

Fuel utilization by cells of the immune system

Calder

1995

Proc. Nutr. Soc.

101

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Incorporation of palmitic acid or oleic acid into macrophage membrane lipids exerts differential effects on the function of normal mouse peritoneal macrophages

Cited by 48 publications

References 27 publications

The Effect of Dietary Fatty Acid Manipulation on Phagocytic Activity and Cytokine Production by Peritoneal Cells from Balb/c Mice.

The Effect of Dietary Fatty Acid Manipulation on Phagocytic Activity and Cytokine Production by Peritoneal Cells from Balb/c Mice.

Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys.

Fuel utilization by cells of the immune system

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