Incorporation of inorganic bioceramics into electrospun scaffolds for tissue engineering applications: A review

Bahremandi-Toloue, Elahe; Mohammadalizadeh, Zahra; Mukherjee, Shayanti; Karbasi, Saeed

doi:10.1016/j.ceramint.2021.12.125

Cited by 46 publications

(13 citation statements)

References 323 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…n-BGs are also materials widely used in bone tissue engineering due to their biocompatibility and the ability to attract osteogenic cells as they are resorbed when implanted in bone tissue [ 49 ]. In addition, their ability to stimulate bone healing has been demonstrated due to their ability to join the bone by depositing a layer of hydroxyapatite on their surface, stimulating cell differentiation [ 50 ] and proangiogenic properties [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

Scaffolds based on biopolymers and nanomaterials with appropriate mechanical properties and high biocompatibility are desirable in tissue engineering. Therefore, polylactic acid (PLA) nanocomposites were prepared with ceramic nanobioglass (PLA/n-BGs) at 5 and 10 wt.%. Bioglass nanoparticles (n-BGs) were prepared using a sol–gel methodology with a size of ca. 24.87 ± 6.26 nm. In addition, they showed the ability to inhibit bacteria such as Escherichia coli (ATCC 11775), Vibrio parahaemolyticus (ATCC 17802), Staphylococcus aureus subsp. aureus (ATCC 55804), and Bacillus cereus (ATCC 13061) at concentrations of 20 w/v%. The analysis of the nanocomposite microstructures exhibited a heterogeneous sponge-like morphology. The mechanical properties showed that the addition of 5 wt.% n-BG increased the elastic modulus of PLA by ca. 91.3% (from 1.49 ± 0.44 to 2.85 ± 0.99 MPa) and influenced the resorption capacity, as shown by histological analyses in biomodels. The incorporation of n-BGs decreased the PLA crystallinity (from 7.1% to 4.98%) and increased the glass transition temperature (Tg) from 53 °C to 63 °C. In addition, the n-BGs increased the thermal stability due to the nanoparticle’s intercalation between the polymeric chains and the reduction in their movement. The histological implantation of the nanocomposites and the cell viability with HeLa cells higher than 80% demonstrated their biocompatibility character with a greater resorption capacity than PLA. These results show the potential of PLA/n-BGs nanocomposites for biomedical applications, especially for long healing processes such as bone tissue repair and avoiding microbial contamination.

show abstract

Section: Resultsmentioning

confidence: 99%

Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For instance, scaffolds for musculoskeletal tissue repair should not only simultaneously promote osteogenesis and angiogenesis but should also display appropriate mechanical properties comparable to the targeted tissues, such as ligament, bone, or cartilage. Consequently, functional bioceramics are often added as a reinforcing phase to improve the mechanical properties of the scaffold as well as afford the sustained release of therapeutic ions for functional tissue repair [ 88 ]. The interconnected porous structure of the electrospun nanofibers allows for cell adhesion which, when combined with the highly bioactive properties of BG, may further enhance the potential of inorganic–organic nanofibers.…”

Section: Electrospun Inorganic Nanofibers For Tissue Engineering Appl...mentioning

confidence: 99%

Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair

Cui

Shen

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

Tissue engineering (TE) has attracted the widespread attention of the research community as a method of producing patient-specific tissue constructs for the repair and replacement of injured tissues. To date, different types of scaffold materials have been developed for various tissues and organs. The choice of scaffold material should take into consideration whether the mechanical properties, biodegradability, biocompatibility, and bioresorbability meet the physiological properties of the tissues. Owing to their broad range of physico-chemical properties, inorganic materials can induce a series of biological responses as scaffold fillers, which render them a good alternative to scaffold materials for tissue engineering (TE). While it is of worth to further explore mechanistic insight into the use of inorganic nanomaterials for tissue repair, in this review, we mainly focused on the utilization forms and strategies for fabricating electrospun membranes containing inorganic components based on electrospinning technology. A particular emphasis has been placed on the biological advantages of incorporating inorganic materials along with organic materials as scaffold constituents for tissue repair. As well as widely exploited natural and synthetic polymers, inorganic nanomaterials offer an enticing platform to further modulate the properties of composite scaffolds, which may help further broaden the application prospect of scaffolds for TE.

show abstract

“…Therefore, a fabricated scaffold, through mixing different components, can show better properties compared to one fabricated by a single polymer; however, there is still room for improvement because of the lack of functional groups, hydrophobicity, and mechanical instability in the PHB/starch scaffold, which these issues need to be addressed. It is suggested that the application of nano llers in a ternary blend can signi cantly affect the physical, chemical, mechanical, and biological features of blend composites [26,27]. Halloysite nanotube (HNT; Al 2 Si 2 O 5 (OH) 4 .nH 2 O) is a costly effective, nontoxic, and environmentally friendly clay nano ller, which can suggest desirable mechanical strength due to its high aspect ratio that enhances the mechanical and cellular properties, showing a potential application in ACTR.…”

Section: Introductionmentioning

confidence: 99%

A core-shell electrospun scaffold including extracellular matrix and chitosan to promote articular cartilage tissue regeneration

Movahedi

Karbasi

2023

Preprint

Self Cite

View full text Add to dashboard Cite

Electrospinning is known as a versatile technique for articular cartilage tissue regeneration (ACTR) due to its excellent potential to produce a fibrous scaffold that mimics the extracellular matrix (ECM) of native tissue. However, there is a need to promote the biological performance of scaffolds maintaining their mechanical strength. In this study, a core-shell polyhydroxybutyrate (PHB)-starch/halloysite nanotubes (HNTs) @ ECM-chitosan (Cs) scaffold was prepared via the coaxial electrospinning method. The results exhibited a narrower fiber diameter of up to 164 ± 24 nm with an appropriate pore size and porosity after incorporating Cs and ECM. Moreover, the core-shell scaffold showed an enhanced Young’s modulus up to 4.45 ± 0.1 MPa that could support chondrocyte cell growth. After that, the wettability and in vitro degradability of the core-shell scaffold were induced due to the hydrophilic nature of shell components. Also, chondrocyte cells had more viability and attachment on the core-shell structure proving the potential of core-shell fibers for biomedical applications. In conclusion, the results showed that the core-shell structured PHB-starch/HNTs @ ECM-Cs could be a suitable candidate for further trial towards ACTR.

show abstract

Incorporation of inorganic bioceramics into electrospun scaffolds for tissue engineering applications: A review

Cited by 46 publications

References 323 publications

Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications

Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications

Electrospinning Inorganic Nanomaterials to Fabricate Bionanocomposites for Soft and Hard Tissue Repair

A core-shell electrospun scaffold including extracellular matrix and chitosan to promote articular cartilage tissue regeneration

Contact Info

Product

Resources

About