Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation

Chan, Jun Yong; Zhang, Huacheng; Nolvachai, Yada; Hu, Yaoxin; Zhu, Haijin; Forsyth, Maria; Gu, Qinfen; Hoke, David E.; Zhang, Xiwang; Marriot, Philip J.; Wang, Huanting

doi:10.1002/anie.201810925

Cited by 123 publications

(62 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Homochiral metal-organic frameworks have also gained much attention because of their chiral properties and disposition for chiral separation [106]. A homochiral zeolitic imidazolate framework-8 (ZIF-8) membrane was synthesized by incorporating a natural amino acid, l-histidine, and presented selectivity for the R-enantiomer of 1-phenylethanol over the S-enantiomer, with enantiomeric excess up to 76% [110]. Taking inspiration from biological channels, a β-barrel transmembrane protein ferric hydroxamate uptake component A (FhuA) was re-engineered into a chiral channel protein (FhuAF4) to separate the racemate of D-/L-arginine with an enantioselectivity of 1.92 and an enantiomeric excess percentage of 23.91 [111].…”

Section: Other Enantioseparation Methodsmentioning

confidence: 99%

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

2020

View full text Add to dashboard Cite

Enantiomeric separation is a key step in the development of a new chiral drug. Preparative liquid chromatography (LC) continues to be the technique of choice either during the drug discovery process, to achieve a few milligrams, or to a scale-up during the clinical trial, needing kilograms of material. However, in the last few years, instrumental and technical developments allowed an exponential increase of preparative enantioseparation using other techniques. Besides LC, supercritical fluid chromatography (SFC) and counter-current chromatography (CCC) have aroused interest for preparative chiral separation. This overview will highlight the importance to scale-up chiral separations in Medicinal Chemistry, especially in the early stages of the pipeline of drugs discovery and development. Few examples within different methodologies will be selected, emphasizing the trends in chiral preparative separation. The advantages and drawbacks will be critically discussed.

show abstract

Section: Other Enantioseparation Methodsmentioning

confidence: 99%

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

2020

View full text Add to dashboard Cite

show abstract

“…Recently, Chan et al fabricated a homochiral MOF membrane by introducing a natural amino acid, l ‐histidine ( l ‐His), into ZIF‐8. The l ‐His is a derivative of imidazole, so it can replace part of mim in the ZIF‐8 without destroying the zeolitic framework of ZIF‐8, leaving the chiral amino structure in the cavity of ZIF‐8 to provide a chiral environment.…”

Section: Applications Of Pmfmsmentioning

confidence: 99%

Polycrystalline Advanced Microporous Framework Membranes for Efficient Separation of Small Molecules and Ions

et al. 2019

Self Cite

View full text Add to dashboard Cite

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201902009.Advanced porous framework membranes with excellent selectivity and high permeability of small molecules and ions are highly desirable for many impor tant industrial separation applications. There has been significant progress in the fabrication of polycrystalline microporous framework membranes (PMFMs) in recent years, such as metal-organic framework and covalent organic framework membranes. These membranes possess small pore sizes, which are comparable to the kinetic diameter of small molecules and ions on the angstrom scale, very low thickness, down to tens to hundreds of nano meters, highly oriented crystalline structures, hybrid membrane structures, and specific functional groups for enhancing membrane selectivity and per meability. Recent advances in the fabrication methods of advanced PMFMs are summarized. Following this, four emerging separation applications of these advanced microporous framework membranes, including gas separa tion, water desalination, ion separation, and chiral separation, are highlighted and discussed in detail. Finally, a summary and some perspectives of future developments and challenges in this exciting research field are presented.

show abstract

“…Over the past 2 decades, MOFs have received much attention in gas storage, catalysis, sensing and even in biomedicine fields . Particularly, changes in the structure and properties of MOFs will result in changes in fluorescence, so MOF‐based fluorescence probes have been a topic of research.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in fluorescence sensors based on DNA–MOF hybrids

Cao

et al. 2020

Luminescence

View full text Add to dashboard Cite

In this review, the recent advances in the development of fluorescence sensors based on DNA and metal-organic framework hybrids have been reported for nucleic acid, metal ion and amino acid detection. The main detection mechanism depends on different adsorption capacities of MOFs towards different DNA structures (single-stranded DNA, double-stranded DNA), and consequently the fluorescence intensity of probe DNA is changed. These results might open up a way to study their potential application in material science and clinical diagnosis of some related diseases. K E Y W O R D S DNA, fluorescence, metal-organic frameworks, sensor

show abstract

Incorporation of Homochirality into a Zeolitic Imidazolate Framework Membrane for Efficient Chiral Separation

Cited by 123 publications

References 53 publications

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

Polycrystalline Advanced Microporous Framework Membranes for Efficient Separation of Small Molecules and Ions

Recent advances in fluorescence sensors based on DNA–MOF hybrids

Contact Info

Product

Resources

About