Recent advances in fluorescence sensors based on DNA–MOF hybrids

Abstract

In this review, the recent advances in the development of fluorescence sensors based on DNA and metal-organic framework hybrids have been reported for nucleic acid, metal ion and amino acid detection. The main detection mechanism depends on different adsorption capacities of MOFs towards different DNA structures (single-stranded DNA, double-stranded DNA), and consequently the fluorescence intensity of probe DNA is changed. These results might open up a way to study their potential application in material science and clinical diagnosis of some related diseases. K E Y W O R D S DNA, fluorescence, metal-organic frameworks, sensor

Metal–organic frameworks towards bio-medical applications

“…MOFs are among the most promising classes of materials for bioapplications reported within the past two decades. Some of these solids are biodegradable and biocompatible, with a structure and composition that can be easily tuned to optimize the loading capacities (drugs, gases) and release properties to meet the requirements for drug delivery systems (DDS), 18,19 imaging, [19][20][21][22] sensing [23][24][25][26][27][28] and tissue engineering.…”

Highly sensitive and selective detection of melamine in dairy products by turn‐on fluorescence of ultrathin graphitic carbon nitride nanosheets

“…[ 16 ] Through turn‐on and/or turn‐off pathways, the luminophores could sensitively and selectively respond to certain analytes. [ 17,18 ] Therefore, detection behaviour could be realized by monitoring the fluorescence signal or even by observation with the naked eye. [ 19 ] To date, several chemosensors for melamine based on fluorescence technology have been successfully developed.…”

Porous organic cage for enantiomeric fluorescence recognition of amino acid and hydroxy acid

“…[ 16,17 ] Unlike other popular coordinated polymers, such as metal–organic frameworks (MOFs) or covalent–organic frameworks (COFs), POCs are soluble with inherent pores in solvents such as dichloromethane and alcohols. [ 18–20 ] In the according solutions, POCs are convenient for engineering and further application in diverse fields, this makes them advantageous over MOFs [ 21 ] or COFs. [ 22 ] Moreover, when the diamines for the construction of the cages are chiral, the POCs could be endowed with inherent chiral structure.…”