Incorporation of biomolecules in Metal-Organic Frameworks for advanced applications

An, Hongde; Li, Mingmin; Gao, Jia; Zhang, Zhenjie; Ma, Shengqian; Chen, Yao

doi:10.1016/j.ccr.2019.01.001

Cited by 239 publications

(140 citation statements)

References 150 publications

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“…194 For example, biomolecules, such as amino acids, peptides, and nucleic bases, as well as biocompatible metal cations (Fe, Zn, and Cu), were used as ligands in the construction of this MOF subclass. 195,196 A variety of hybrid materials, such as biopolymer@MOFs, are also of considerable interest. 197 It should be noted the use of MPs whose polymeric chains include nontraditional heteroatoms, for example, selenium.…”

Section: Metallodendrimersmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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Section: Metallodendrimersmentioning

confidence: 99%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…Coprecipitation is another strategy that includes immobilization of enzymes during the preparation of MOFs . By embedding the enzyme in MOFs, this scaffold can shield the enzymes and enhance their biological activity and long‐term stability even under harsh conditions . This technique is restrained to a limited number of MOFs that can be prepared under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Micro‐ and Mesoporous Zn‐Based Metal–Organic Frameworks Templated by Hydrogels: Their Use for Enzyme Immobilization and Catalysis of Knoevenagel Reaction

Cheng

Švec

et al. 2019

Small

113

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Encapsulation of enzymes in metal–organic frameworks (MOFs) is often obstructed by the small size of the orifices typical of most reported MOFs, which prevent the passage of larger‐size enzymes. Here, the preparation of hierarchical micro‐ and mesoporous Zn‐based MOFs via the templated emulsification method using hydrogels as a template is presented. Zinc‐based hydrogels featuring a 3D interconnecting network are first produced via the formation of hydrogen bonds between melamine and salicylic acid in which zinc ions are well distributed. Further coordination with organic linkers followed by the removal of the hydrogel template produces hierarchical Zn‐based MOFs containing both micropores and mesopores. These new MOFs are used for the encapsulation of glucose oxidase and horseradish peroxidase to prove the concept. The immobilized enzymes exhibit a remarkably enhanced increased operational stability and enzymatic activity with a kcat/km value of 85.68 mm s–1. This value is 7.7‐fold higher compared to that found for the free enzymes in solution, and 2.7‐fold higher than enzymes adsorbed on conventional microporous MOFs. The much higher catalytic activity of the mesoporous conjugate for Knoevenagel reactions is demonstrated, since the large pores enable easier access to the active sites, and compared with that observed for catalysis using microporous MOFs.

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“…Detection results in vivo will be totally different from detection in vitro. In future, more attention could be focused on the following aspects: (i) the development of water‐stable and low toxic MOFs useful for potential clinical applications of DNA–MOFs as biosensors; and (ii) besides currently developed detection methods, more facile and reasonable approaches are needed to prepare smart biosensors based on DNA–MOFs …”

Section: Conclusion and Future Prospectsmentioning

confidence: 62%

Recent advances in fluorescence sensors based on DNA–MOF hybrids

Cao

et al. 2020

Luminescence

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In this review, the recent advances in the development of fluorescence sensors based on DNA and metal-organic framework hybrids have been reported for nucleic acid, metal ion and amino acid detection. The main detection mechanism depends on different adsorption capacities of MOFs towards different DNA structures (single-stranded DNA, double-stranded DNA), and consequently the fluorescence intensity of probe DNA is changed. These results might open up a way to study their potential application in material science and clinical diagnosis of some related diseases. K E Y W O R D S DNA, fluorescence, metal-organic frameworks, sensor

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Incorporation of biomolecules in Metal-Organic Frameworks for advanced applications

Cited by 239 publications

References 150 publications

Recent advances in metallopolymer-based drug delivery systems

Recent advances in metallopolymer-based drug delivery systems

Hierarchical Micro‐ and Mesoporous Zn‐Based Metal–Organic Frameworks Templated by Hydrogels: Their Use for Enzyme Immobilization and Catalysis of Knoevenagel Reaction

Recent advances in fluorescence sensors based on DNA–MOF hybrids

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