Abstract:To investigate the association between incorporation of 1-f0-D-arabinofuranosylcytosine (ara-C) into herpes simplex virus type 1 (HSV-1) DNA and mutagenesis at selected genetic loci, we grew virus in the presence or absence of ara-C and compared the mutation frequencies. Both the forward mutation frequency of HSV-1 (KOS) to the tk-phenotype and the reversion frequency of a temperature-sensitive mutant to the nontemperature-sensitive (ts+) phenotype were significantly increased following growth in ara-C. When t… Show more
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