Design of Nucleoside Analogs as Potential Antiviral Agents

Robins, Roland K.; Revankar, Ganapathi R.

doi:10.1007/978-1-4684-7275-2_2

Cited by 24 publications

(9 citation statements)

References 167 publications

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“…Nucleosides and amino acids rapidly cross the plasma membrane of the cells by a facilitated transport mechanism (9), thus gaining rapid entry into the cells. The curcumin molecule, meeting such requirements, was chosen for this dual purpose.…”

Section: Introductionmentioning

confidence: 99%

Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against β-Lactamase-Producing Microorganisms

et al. 2001

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In the present study curcumin bioconjugates, viz. di-O-glycinoylcurcumin (I), di-O-glycinoyl-C(4)-glycylcurcumin (II), 5'-deoxy-5'-curcuminylthymidine (5'-cur-T) (IV), and 2'-deoxy-2'-curcuminyluridine (2'-cur-U) (V) have been synthesized and characterized by elemental analysis and (1)H NMR. The turmeric peptide (Tp) was isolated from the aqueous turmeric extract of the turmeric rhizome. The antibacterial activity of these four bioconjugates and also of the turmeric peptide and sodium salt of curcumin (III) have been tested particularly for beta-lactamase-producing microorganisms.

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Section: Introductionmentioning

confidence: 99%

Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against β-Lactamase-Producing Microorganisms

et al. 2001

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“…[1] As a result, manipulation of the nucleoside scaffold both in the heterocyclic base and the sugar moiety has resulted in a number of potent antiviral and anticancer drugs. [1–4] In that regard, a number of uridine and 5-substituted 2′-deoxyuridine nucleoside analogues (shown in Figure 1) such as 5-(E)-(bromovinyl)-2′-deoxyuridine (BVDU, [5–7] A ), 5-trifluoromethyl-2′-deoxyuridine (F3TDR, B ), 5-iodo-2′-deoxyuridine (IUDR, C ) [8] and 5-bromo-2′-deoxyuridine ( D ), and 5-fluoro-2′-deoxyuridine ( E ) have exhibited antiviral and/or anticancer activity. [7,9–11] …”

Section: Introductionmentioning

confidence: 99%

Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents

Seley‐Radtke

Sunkara

2009

Nucleosides, Nucleotides & Nucleic Acids

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The discovery of azidothymidine’s (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the design of additional thymidine analogues. One drawback of many nucleoside analogues is the toxicity that often arises due to phosphorylation by cellular kinases. In order to overcome this problem, a number of truncated nucleosides lacking the 4 ′-hydroxymethyl group have been synthesized. In that regard, the synthesis and preliminary biological results for two truncated carbocyclic thymidine analogues are presented herein.

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“…The utility of analogues of purine nucleosides as drugs is well documented [6,7]. Modified nucleosides and nucleic acid bases have been the subject of many studies due to their potential activity as enzyme inhibitors resulting in antitumor [8] and antiviral activity [9]. Early work focused on the development and synthesis of boron containing purine and pyrimidine bases [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

2008

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Derivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B 8 N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH 2 R group of the azanonaborane of the type [(RH 2 N)B 8 H 11 NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions.© Versita Warsaw and Springer-Verlag Berlin Heidelberg.

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Design of Nucleoside Analogs as Potential Antiviral Agents

Cited by 24 publications

References 167 publications

Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against β-Lactamase-Producing Microorganisms

Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against β-Lactamase-Producing Microorganisms

Carbocyclic Thymidine Analogues for Use as Potential Therapeutic Agents

Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

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