Incorporation and effects of dietary eicosapentaenoate (20 : 5(n − 3)) on plasma and erythrocyte lipids of the marmoset following dietary supplementation with differing levels of linoleic acid

McMurchie, Edward J.; Rinaldi, Josephine A.; Burnard, Sharon L.; Patten, Glen S.; Neumann, Mark A.; McIntosh, Graeme H.; Abbey, Mavis; Gibson, Robert A.

doi:10.1016/0005-2760(90)90146-o

Cited by 29 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the inhibition of n‐3 LCPUFA synthesis, there are data from both animals and humans that diets containing high amounts of LA are associated with reduced incorporation of preformed n‐3 LCPUFA into tissue phospholipids (McMurchie et al . 1990; Lands et al .…”

Section: La Also Inhibits Incorporation Of Lcpufamentioning

confidence: 99%

See 1 more Smart Citation

Conversion of linoleic acid and alpha‐linolenic acid to long‐chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life

Gibson

Mühlhäusler

Makrides

2011

Maternal & Child Nutrition

Self Cite

211

172

View full text Add to dashboard Cite

Over the past two decades, there has been a marked shift in the fatty acid composition of the diets of industrialized nations towards increased intake of the n-6 fatty acid linoleic acid (LA, 18:2n-6), largely as a result of the replacement of saturated fats with plant-based polyunsaturated fatty acid (PUFA). While health agencies internationally continue to advocate for high n-6 PUFA intake combined with increased intakes of preformed n-3 long-chain PUFAs (LCPUFA) docosahexaenoic acid (DHA, 22:6n-3) and eicosapentaenoic acid (EPA, 20:5n-3) to reduce the incidence of cardiovascular disease (CVD), there are questions as to whether this is the best approach. LA competes with alpha-linolenic acid (18:3n-3) for endogenous conversion to the LC derivatives EPA and DHA, and LA also inhibits incorporation of DHA and EPA into tissues. Thus, high-LA levels in the diet generally result in low n-3 LCPUFA status. Pregnancy and infancy are developmental periods during which the fatty acid supply is particularly critical. The importance of an adequate supply of n-3 LCPUFA for ensuring optimal development of infant brain and visual systems is well established, and there is now evidence that the supply of n-3 LCPUFA also influences a range of growth, metabolic and immune outcomes in childhood. This review will re-evaluate the health benefits of modern Western diets and pose the question of whether the introduction of similar diets to nations with emerging economies is the most prudent public health strategy for improving health in these populations.

show abstract

Section: La Also Inhibits Incorporation Of Lcpufamentioning

confidence: 99%

“…1992). In one of these studies, preformed EPA was given to non‐human primates consuming a background diet containing either low (7%) or high (33%) levels of LA, and incorporation of EPA into tissue phospholipids was significantly lower in the high‐LA group (McMurchie et al . 1990).…”

Section: La Also Inhibits Incorporation Of Lcpufamentioning

confidence: 99%

Conversion of linoleic acid and alpha‐linolenic acid to long‐chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life

Gibson

Mühlhäusler

Makrides

2011

Maternal & Child Nutrition

Self Cite

211

172

View full text Add to dashboard Cite

show abstract

“…Furthermore, high LA diets are also reported to reduce the incorporation of preformed n-3 LCPUFAs into tissue/membrane phospholipids in animals and humans (McMurchie et al, 1990;Lands et al, 1992). However, the large number of studies showing an extremely low conversion of ALA to EPA, n-3 DPA, and in particular DHA in animals and humans when diets contain high amounts of LA, are difficult to ignore, particularly because these derivatives are the n-3 LCPUFAs that are the counterbalance for attenuating the inflammatory processes that are augmented by the excessive n-6 AA.…”

Section: Synthesis and Metabolism Of Efasmentioning

confidence: 99%

Authorised EU health claims for the essential fatty acids

Wahle

Heys

Rotondo

2015

Foods, Nutrients and Food Ingredients With Authorised EU Health Claims: Volume 2

View full text Add to dashboard Cite

“…The 4 diets contained 14-15% fat and were of equivalent calorific value (23 kJ/g). Full details on the preparation and composition of the diets have been described earlier [27]. The atherogenic diet was prepared by supplementation of the colony diet with 10% sheep kidney fat and 0.2% cholesterol (Ajax Chemical Company, Sydney, Australia) and the EPA supplemented diet contained 0.8% wet weight of an EPA ethyl ester concentrate, (75% EPA) (supplied by Dr. Yasushi Tamura, Chiba University Medical School, Chiba, Japan).…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Fish Oils Modulate Blood Pressure and Vascular Contractility in the Rat and Vascular Contractility in the Primate

et al. 1995

Self Cite

View full text Add to dashboard Cite

The effect of dietary fish oils on development of hypertension and vascular response in vitro were studied in rats and a primate. Dietary fish oils (MaxEPA and an n-3 ethyl ester concentrate of higher EPA and DHA content) were administered to spontaneously hypertensive (SHR), stroke-prone spontaneously hypertensive (SHR-SP) and a backcross of SHR and Wistar Kyoto (SHR/WKY) rats from 4-16 weeks of age. Blood pressure was monitored during the feeding period and vascular responses measured in the aorta and mesenteric vascular bed in vitro. Depending on the strain of rat used and the composition of the fish oil the attenuation in blood pressure was 10-26 mmHg. Fish oils attenuated the response mediated by sympathetic nerve stimulation or intralumenal norepinephrine in the perfused mesenteric vascular bed preparation from the SHR. This attenuation was more pronounced for fish oils enriched with eicosapentaenoic acid and docosahexaenoic acid and was more prominent in the SHR and SHR/WKY backcross than it was in the SHR-SP. Prostanoid synthesis or nitric oxide modulation of alpha-adrenoceptor responses were shown not to be involved in the attenuation of vascular responses produced by fish oil. The maximum contraction of aortic ring preparations in response to norepinephrine (NE) was significantly smaller in SHR than WKY rats fed olive oil and for SHR rats maintained on fish oils the contraction was close to WKY olive oil values. Evidence was obtained also for a modulation of vasoconstrictor responses by dietary fish oils in the perfused mesenteric bed of the marmoset monkey.

show abstract

Incorporation and effects of dietary eicosapentaenoate (20 : 5(n − 3)) on plasma and erythrocyte lipids of the marmoset following dietary supplementation with differing levels of linoleic acid

Cited by 29 publications

References 38 publications

Conversion of linoleic acid and alpha‐linolenic acid to long‐chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life

Conversion of linoleic acid and alpha‐linolenic acid to long‐chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life

Authorised EU health claims for the essential fatty acids

Fish Oils Modulate Blood Pressure and Vascular Contractility in the Rat and Vascular Contractility in the Primate

Contact Info

Product

Resources

About