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NA DOC resulted in substantial improvement in responses to DOC.

This meta-analysis has demonstrated that nutritional support supplemented with key nutrients results in a significant reduction in the risk of developing infectious complications and reduces the overall hospital stay in patients with critical illness and in patients with gastrointestinal cancer. However, there is no effect on death. These data have important implications for the management of such patients.

On behalf of the Recovery Study Group. Psychological, surgical and sociodemographic predictors of pain outcomes after breast cancer surgery: a population-based cohort study, PAIN (2013), doi: http://dx.doi.org/10. 1016/j.pain.2013.09.028 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 25Two multiple logistic regression models were then developed to predict chronic pain status 26(presence or absence of chronic pain) at 4 and 9 months after controlling for other variables. 27Included variables were specified a priori by the Study Group, based upon previous (Table 3). The pattern of symptoms, in terms of location and frequency, 10was relatively stable rather than dynamic, when compared across follow-up time points. By 9 11 months postoperatively, more than half of women felt that their symptoms were unchanged, 12rather than improving over time (Table 3). Regarding symptom attribution, breast surgery 13 was reported to be the cause of symptoms for 94% women with chronic pain at 4 months 14 and 89% of women at 9 months after surgery. 16Pain intensity and character 17Most women reported chronic pain of mild intensity (Table 4) (Table 7). Decreased psychological robustness, type of axillary 5 surgery and more severe acute postoperative pain at rest increased the risk of experiencing 6 moderate to severe pain at 9 months postoperatively. Several risk factors were of borderline 7 statistical significance: younger age and having had multiple surgical procedures were 8 associated with greater pain intensity at 4 months, and chronic preoperative pain was 9 associated with greater pain intensity at 9 months postoperatively.This multicentre prospective cohort study investigated psychological, sociodemographic, and 3 surgical risk factors, adjusted for intraoperative nerve handling, on painful adverse outcomes 4 captured at multiple time points after resectional surgery for primary breast cancer. 6We found a high incidence of chronic pain, with two-thirds of women reporting pain-related 23The strengths of our study include being the first epidemiological study to investigate 27of intraoperative data collection forms; we achieved 97% complete data on nerve handling. 28 20We adjusted for other potential confounding factors, specified a priori, identified from existing 1 literature and from our own research [9-11; 30; 43; 50; 54]

[(18)F]-FDG PET imaging of primary and metastatic breast cancer after a single pulse of chemotherapy may be of value in the prediction of pathologic treatment response.

NK and LAK cells, through the use of immune biologic modifiers, have been demonstrated to have a therapeutic role in the treatment of human cancers. Further studies are required to determine the optimal dosages and combinations of chemotherapeutic agents, the timing of surgery, and the adjuvant use of immune biologic response modifiers. An increasing awareness and understanding of this field, may allow for the future development of anti-cancer therapies.

NA DOC resulted in substantial improvement in responses to DOC.