Incompatibility of undiluted busulfan injection with a needle-free valve

Cueto-Sola, Margarita; Belda-Furió, Miriam; Borrell-García, Carmela; López-Briz, Eduardo; Poveda‐Andrés, José Luis

doi:10.2146/ajhp140111

Cited by 3 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BU is known to be incompatible with polycarbonate plastic and is recommended for infusion through specific filters. [4][5][6] Given the results of both the chemical and visual inspections of BU when infused via IV administration sets A and B, there is no apparent difference in BU concentration when administered by either IV administration set. This study did not test the composition of the IV administration set materials and therefore cannot conclude the presence or absence of polycarbonate plastic.…”

Section: Resultsmentioning

confidence: 99%

“…4 Becton Dickinson (BD, North Ryde, NSW, Australia) 1-mL syringes are made of polycarbonate and Loboda et al 5 reported the occurrence of precipitation of BU when 1-mL BD syringes were used during compounding. Cueto-Sola et al 6 also reported BU was incompatible with the Carefusion model MFX 231E (Barcelona, Spain) secondary system. Therefore, it is well documented that BU is unstable with certain types of plastics contained in syringes and filters, particularly those containing polycarbonate.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Compatibility of intravenous busulfan with BBraun giving sets, fludarabine and Posiflush

Smith

Shergold

McWhinney

2020

Pharmacy Practice and Res

View full text Add to dashboard Cite

Background Intravenous busulfan (BU) is known to be incompatible with certain plastics and is recommended for infusion through specific filters. The Queensland Children's Hospital has experienced precipitation on two occasions where BU was administered following a fludarabine (FLU) infusion via a BBraun giving set containing a filter, and after flushing a line with Posiflush (PF). Aim This study determined the chemical and visual compatibility of BU with FLU, PF and BBraun giving sets, with or without a filter. Methods Infusion solutions of 0.5 mg/mL BU were prepared and a control infusion of BU was passed through Giving set B (no filter). The control was compared to three test infusions passed through Giving set A (filter included). Samples were taken at 0, 1, 2 and 3 h to determine BU concentrations via HPLC. Infusions were visualised for precipitation. Admixtures of 0.25 mg/mL BU and 0.85 mg/mL FLU or 0.25 mg/mL BU and PF in a syringe were prepared, visualised at 1 h and tested by HPLC to determine BU concentration. Results There were no differences in BU concentrations at 1, 2 or 3 h after infusion through Giving set A versus Giving set B. No precipitation occurred. Admixture samples of BU with FLU or BU with PF also showed no precipitation. BU concentrations were also maintained in the samples. Discussion BBraun giving sets with, or without a filter, are compatible with BU and have no affect on BU concentration and do not cause precipitation. BU is compatible with both FLU and PF as an admixture.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Compatibility of intravenous busulfan with BBraun giving sets, fludarabine and Posiflush

Smith

Shergold

McWhinney

2020

Pharmacy Practice and Res

View full text Add to dashboard Cite

show abstract

“…This excipient is very aggressive to plastics and has recently been involved in an incompatibility with a needle-free valve. 1 The crystal clear barrel of the 1 ml Luer-Lock BD syringe is made of polycarbonate. 2 However, this information is not written on the package insert of the syringes, and is only available on the internet website of Becton Dickinson.…”

mentioning

confidence: 99%

“…This excipient is very aggressive to plastics and has recently been involved in an incompatibility with a needle-free valve. 1…”

mentioning

confidence: 99%

Incompatibility of busulfan with 1 ml Luer-Lock syringes

Loboda

Lider

Vigneron

2015

J Oncol Pharm Pract

View full text Add to dashboard Cite

Stability of Bendamustine Solutions: Influence of Sodium Chloride Concentration, Temperature and Container

Vigneron

D’Huart

Demoré

2018

Pharmaceutical Technology in Hospital Pharmacy

View full text Add to dashboard Cite

Abstract Background Bendamustine is used for the treatment of non-Hodgkin lymphoma, chronic lymphocytic leukaemia and myeloma. The stability of bendamustine is highly dependent on temperature and chloride-ion concentration. Limited stability data are available. The objective of this work was to study the stability of the bendamustine reconstituted solution at 2.5 mg/mL and the diluted solution in normal saline and 1.5 % sodium chloride to evaluate a potential increase in stability. Methods A stability indicating High Performance Liquid Chromatography method with Diode Array Detection was used. A first study was carried out in glass vials and then in polyolefin containers at 0.25 and 0.60 mg/mL. Solutions were stored at room temperature and at 2–8 °C for 7 days. Results Stability was defined as a concentration above 95 % of the initial concentration [10]. The reconstituted solution at 2.5 mg/mL was stable for only 2 hours at room temperature and 8 hours at 2–8 °C. The stability of diluted solutions was in accordance with the manufacturer’s recommendations of 3.5 hours at room temperature and 48 hours at 2–8 °C. The addition of sodium chloride doesn’t increase the stability for preparation in infusion in daily practice. Conclusions The information brought by this study is an 8-hour stability of the reconstituted solution at 2–8 °C.

show abstract

Incompatibility of undiluted busulfan injection with a needle-free valve

Cited by 3 publications

References 2 publications

Compatibility of intravenous busulfan with BBraun giving sets, fludarabine and Posiflush

Compatibility of intravenous busulfan with BBraun giving sets, fludarabine and Posiflush

Incompatibility of busulfan with 1 ml Luer-Lock syringes

Stability of Bendamustine Solutions: Influence of Sodium Chloride Concentration, Temperature and Container

Contact Info

Product

Resources

About