Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities

Abstract

The study aimed to include the isolated vitexin of Jatropha mutabilis in the β-cyclodextrin cavity to improve the solubility of this flavone. Its characterization was performed by techniques such as 1 H NMR/ROESY (Nuclear Magnetic Resonance Spectroscopy), FT-IR (Infrared Spectroscopy with Fourier Transform), SEM (Morphological analysis of IC by Scanning Electron Microscopy) and dissolution study in vitro . In addition, the following activities were evaluated in the animal models: expectorant, phenol red dosage in bronchoalveolar lavage and antitussive, cough induced by citric acid. In the characterization of the complex, interaction between hydrogens of ring B of vitexin and (H3) of β-CD was observed, in addition to changes in morphology. In the dissolution test, an increase in the rate of dissolution of vitexin was observed in the first 30 min for the CI vitexin/β-CD when compared with vitexin. Regarding the pharmacological activity, it was observed that the inclusion complex (IC) vitexin/β-CD in the equivalent doses of 0.2, 1 and 5 mg/kg of flavone presented higher expectorant activity when compared to vitexin (p < 0.05), suggesting increased bioavailability. As for the antitussive activity, both vitexin and the complex had similar effects and were dose independent. In the toxicity test using Artemia salina , vitexin and IC vitexin/β-CD were considered non-toxic. At last, the study efficacy of vitexin/β-CD IC as an expectorant and of vitexin as antitussive. All of these data are being described for the first time.

Pachira macrocarpa Schltdl. & Cham., HPLC Profile, and Neuroprotective Potential via Regulation of JNK, miRNA132, and miRNA-125b

“…macrocarpa extract to AlCl 3 -treated rats inhibited the secretion of IL-8 and IL-33 and reflected their anti-inflammatory activity. Our results were confirmed with the results of Cheetal et al, Costa et al, and Zheng et al, who reported that luteolin, vitexin, and ferulic acid have anticancer, antioxidant, anti-inflammatory, anti-nociceptive, antihypertensive, antispasmodic, antiviral, and antidepressant properties in vivo and in vitro. Several pharmacological actions including antibacterial, antifungal, nematocidal, antiproliferative, and anti-inflammatory (IL-8 and IL-33) activities have been linked to the presence of luteolin, vitexin, and ferulic acid in P.…”

Vitexin‐loaded poly(ethylene glycol) methyl ether‐grafted chitosan/alginate nanoparticles: preparation, physicochemical properties and in vitro release behaviors

“…1(a)). 10,12,22 The mPEG-g-CTS/ALG nanoparticles showed characteristic peaks at 2800-3000 cm −1 (C H stretching) and 1740 cm −1 (C O of the ester bond) belonging to mPEG-g-CTS 33 and oil. 40 They also showed peaks at 1625 cm −1 (asymmetric COO − ) and 1409 cm −1 (symmetric COO − ) that belong to mPEG-g-CTS/ALG polyelectrolyte complexes 33 (Fig.…”

“…Recently, it has received increasing attention due to its antioxidant, 1,6 anti‐inflammatory, 6,7 antinociceptive, 6 antimetastatic, 8 antitumor, 8 antibiofilm and antibacterial 9 properties. However, its poor water solubility, poor absorption in the gastrointestinal tract and low oral bioavailability limit its clinical and therapeutic applications 10‐15 …”

“…However, its poor water solubility, poor absorption in the gastrointestinal tract and low oral bioavailability limit its clinical and therapeutic applications. [10][11][12][13][14][15] Encapsulation is one of the most effective solutions to protect hydrophobic bioactive substances and poorly soluble compounds, e.g. curcumin, 16,17 fish oil 16,17 and nerolidol, 18 which require delivery formulations, and to enhance operational stability of shorthalf-life substances in the bloodstream, e.g.…”

Fabrication and characterization of nanoemulsions for encapsulation and delivery of vitexin: antioxidant activity, storage stability and in vitro digestibility

“…1,3 Therefore, production methods or technologies that increase vitexin solubility require development. Previously, nano-complex and nanoparticles of vitexin were created to enhance its solubility, [3][4][5] but no studies have assessed the development of nanoemulsions as vitexin delivery systems. Therefore, considerable interest has been shown in fabricating vitexinloaded nanoemulsions as an alternative and effective delivery process.…”