2020
DOI: 10.1016/j.heliyon.2020.e05461
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Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities

Abstract: The study aimed to include the isolated vitexin of Jatropha mutabilis in the β-cyclodextrin cavity to improve the solubility of this flavone. Its characterization was performed by techniques such as 1 H NMR/ROESY (Nuclear Magnetic Resonance Spectroscopy), FT-IR (Infrared Spectroscopy with Fourier Transform), SEM (Morphological analysis of IC by Scanning Electron Microscopy) and dissolution study in vitro . In addition, the following activitie… Show more

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Cited by 20 publications
(7 citation statements)
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“…macrocarpa extract to AlCl 3 -treated rats inhibited the secretion of IL-8 and IL-33 and reflected their anti-inflammatory activity. Our results were confirmed with the results of Cheetal et al, Costa et al, and Zheng et al, who reported that luteolin, vitexin, and ferulic acid have anticancer, antioxidant, anti-inflammatory, anti-nociceptive, antihypertensive, antispasmodic, antiviral, and antidepressant properties in vivo and in vitro. Several pharmacological actions including antibacterial, antifungal, nematocidal, antiproliferative, and anti-inflammatory (IL-8 and IL-33) activities have been linked to the presence of luteolin, vitexin, and ferulic acid in P.…”
Section: Discussionsupporting
confidence: 93%
“…macrocarpa extract to AlCl 3 -treated rats inhibited the secretion of IL-8 and IL-33 and reflected their anti-inflammatory activity. Our results were confirmed with the results of Cheetal et al, Costa et al, and Zheng et al, who reported that luteolin, vitexin, and ferulic acid have anticancer, antioxidant, anti-inflammatory, anti-nociceptive, antihypertensive, antispasmodic, antiviral, and antidepressant properties in vivo and in vitro. Several pharmacological actions including antibacterial, antifungal, nematocidal, antiproliferative, and anti-inflammatory (IL-8 and IL-33) activities have been linked to the presence of luteolin, vitexin, and ferulic acid in P.…”
Section: Discussionsupporting
confidence: 93%
“…1(a)). 10,12,22 The mPEG-g-CTS/ALG nanoparticles showed characteristic peaks at 2800-3000 cm −1 (C H stretching) and 1740 cm −1 (C O of the ester bond) belonging to mPEG-g-CTS 33 and oil. 40 They also showed peaks at 1625 cm −1 (asymmetric COO − ) and 1409 cm −1 (symmetric COO − ) that belong to mPEG-g-CTS/ALG polyelectrolyte complexes 33 (Fig.…”
Section: Chemical Structurementioning
confidence: 99%
“…Recently, it has received increasing attention due to its antioxidant, 1,6 anti‐inflammatory, 6,7 antinociceptive, 6 antimetastatic, 8 antitumor, 8 antibiofilm and antibacterial 9 properties. However, its poor water solubility, poor absorption in the gastrointestinal tract and low oral bioavailability limit its clinical and therapeutic applications 10‐15 …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…1,3 Therefore, production methods or technologies that increase vitexin solubility require development. Previously, nano-complex and nanoparticles of vitexin were created to enhance its solubility, [3][4][5] but no studies have assessed the development of nanoemulsions as vitexin delivery systems. Therefore, considerable interest has been shown in fabricating vitexinloaded nanoemulsions as an alternative and effective delivery process.…”
Section: Introductionmentioning
confidence: 99%