Inclusion Complex of Solid State Aspirin with Fulvic Acid: Dissolution, Permeability, Stability and Preliminary Pharmacological Studies

Anwer, Mohammad Khalid; Jamil, Shahid; Ahmad, Maqbool; Ansari, Mohd Nazam; Khan, Tajdar Husain

doi:10.3923/jbs.2013.302.312

Cited by 7 publications

(10 citation statements)

References 2 publications

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“…Fulvic acid and aspirin formulation helps to overcome problem of stability and bioavailability of aspirin. Aspirin formulation with fulvic acid helps to overcome problem of stability and bioavailability of aspirin and gives better results of antiulcerogenic action as compared to pure drug [61]. Experimental data from the studies of Khil'ko and Semenova indicates interactions between humic acid salts and the drug preparations from papaverine hydrochloride, benzohexonium and B-group vitamins.…”

Section: Humic Substances In the Drug Delivery Systemmentioning

confidence: 99%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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Efficiency of therapeutic compounds could be enhanced by encapsulation and covalent attachments to a biomaterial carrier. Complex formation with humic substances is valuable techniques to improve bioactivity of natural products. Fractal structures of humic substances also have adjacent carboxyl and hydroxyl groups. Along with molecular bonding property, reduction-oxidation and association-dissociation capacities of humic substances are considered this as a biomaterial for transform, other molecules, and substances. Immune system responses of humic acid stimulates in the human body. However, pharmaceutical importance of humic substances, demands on evidenced efficacy and a clearly defined chemical composition of the preparations used. Toxicological safety standards also have to be evaluated. This review summarises the application of humic substances as pharmaceuticaly important biomaterial. Research on this zone opened up an application for humic substances in pharmacogonasy.

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Section: Humic Substances In the Drug Delivery Systemmentioning

confidence: 99%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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“…It was reported that Aspirin-fulvic complex prepared by solvent evaporation in molar ratio of 1:0.5 exhibited a partially crystalline nature as an evident by the lack of some characteristic peaks of Aspirin and the rest with reduced intensity. Complex of drug: polymer molar ratio 1:1 and 1:2 exhibited amorphous nature because it does not show any intense peak of the drug 19 . Also Semalty et al 20 found that the x-ray diffraction pattern of Aspirin complex revealed a broad peak similar to the PC indicating that Aspirin was in amorphous form in phospholipid which also confirmed the formation of a phospholipid complex.…”

Section: Figure 1: X-ray Diffraction Of Eudragit Rs100 Microcapsules mentioning

confidence: 99%

“…Anwer et al 19 stated that the appearance or disappearance of the melting endothermic peak of the drug depend on the drug /polymer ratio. This is may be as a result of the insufficient quantity of fulvic acid used in ratio 1:1 and complete disappearance on using 1:2 drug/polymer ratios.…”

Section: Figure 6: Dsc Scanning Of Some Eudragit Rs100 Microcapsules mentioning

confidence: 99%

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2014

IJPSR

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The method of entrapment of the drug in the microcapsules structure prepared with different theoretical drug content (TDC) and having different particle size ranges were studied using x-ray diffraction and DSC analysis methods. Also, in the light of the analysis methods, a trial to correlate the actual microcapsule structure with the actual drug content (ADC) and the division mechanism suggested by the author was also studied. The results showed that the drug entrapped in more than one form in the microcapsule structure. At the first, the drug entrapped in the microcapsules structure as a solid solution form which is concluded as the result of disappearance of all characteristic peaks of the drug in both x-ray diffraction pattern and DSC. The amount of drug in solid solution form depends on the physico-chemical characters of the drug and the polymer. After that increasing TDC leads to increasing the amount of the drug crystal in the microcapsule structure. Between those two forms another minute form may be formed as a result of increasing TDC or /and certain kind of physicchemical interaction between the drug and the polymer. The physical interaction between the drug and the polymer could be concluded from x-ray diffraction patterns and DSC but the chemical one needs further explanations using FTIR. The entrapment process of the drug was found to be reflected on the product sphericity. All analysis results supported what is suggested mechanism during microcapsules formation (Division Mechanism) as a result of appearances or disappearances of drug crystals in addition to its effect on actual drug content. INTRODUCTION: Polymer microspheres are employed to deliver medication in a rate-controlled and sometimes targeted manner. Then the drug is generally released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix.

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“…Aspirin (ASP) is chemically acetyl salicylic acid, a very old medication with high medical values, which possess various activities viz, antiinflammartory, analgesic, and anti-aggregatory activity [1,2]. The carboxyl and ester groups are present in the structure of acetyl salicylic acid, the ester group of ASP is sensitive to hydrolysis in the presence of moisture, which reduces its bioavailability and causes ulceration effects on the human stomach [3][4][5][6]. A strategy must to develop to reduce/inhibit the hydrolysis of ASP.…”

Section: Introductionmentioning

confidence: 99%

“…HPTLC offer many advantages compared to other analytical techniques in terms of reliability, accuracy, robustness and simultaneous analysis of compound [22,23]. The inclusion complexes of ASP with cyclodextrins has been already reported [4,5], this study explored the potential of FA as complexing agent to address the stability problem of ASP in comparison to HPβCD and analyzed by developed HPTLC method.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of HPTLC Method for Studying Stress Degradation of Aspirin in Fulvic Acid Inclusion Complex

Anwer

Ahmed

Ansari

et al. 2020

JPRI

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A new, precise high performance thin layer chromatographic (HPTLC) method for the analysis aspirin (ASP) in inclusion complexes with HPβCD and fulvic acid (FA) was developed and validated as per ICH guidelines. A precoated silica gel aluminium plate 60F-254 and a mixture of solvents, toluene: ethylacetate: formic acid (5:4:1 v/v) were used as stationary and mobile phase, respectively. This developed method was found to give an excellent defined sharp peak at a retention factor (RF) value of 0.52 ± 0.001. The LOQ and LOD values were found 35.29 and 123.54 ng / spot, respectively. The spray dried inclusion complexes of ASP/HPβCD and ASP/FA in the molar ratio 1:1, were subjected for forced degradation under stress conditions, and a significant reduction of ASP degradation were noted in complexed ASP as compared to ASP alone.

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Inclusion Complex of Solid State Aspirin with Fulvic Acid: Dissolution, Permeability, Stability and Preliminary Pharmacological Studies

Cited by 7 publications

References 2 publications

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

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Development and Validation of HPTLC Method for Studying Stress Degradation of Aspirin in Fulvic Acid Inclusion Complex

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